Brown adipose tissue lipid metabolism in morbid obesity: Effect of bariatric surgery‐induced weight loss

We aimed to investigate the effect of bariatric surgery on lipid metabolism in supraclavicular brown adipose tissue in morbidly obese women. We hypothesized that lipid metabolism improves after surgery‐induced weight loss.

[1]  T. Lehtimäki,et al.  Increased Liver Fatty Acid Uptake Is Partly Reversed and Liver Fat Content Normalized After Bariatric Surgery , 2017, Diabetes Care.

[2]  S. Klein,et al.  Roux-en-Y Gastric Bypass Surgery Has Unique Effects on Postprandial FGF21 but Not FGF19 Secretion , 2017, The Journal of clinical endocrinology and metabolism.

[3]  P. Iozzo,et al.  Fatty acid uptake and blood flow in adipose tissue compartments of morbidly obese subjects with or without type 2 diabetes: effects of bariatric surgery. , 2017, American journal of physiology. Endocrinology and metabolism.

[4]  R. Parkkola,et al.  Human Brown Fat Radiodensity Indicates Underlying Tissue Composition and Systemic Metabolic Health , 2017, The Journal of clinical endocrinology and metabolism.

[5]  M. Shestakova,et al.  The Relationship Between Brown Adipose Tissue Content in Supraclavicular Fat Depots and Insulin Sensitivity in Patients with Type 2 Diabetes Mellitus and Prediabetes , 2017, Diabetes technology & therapeutics.

[6]  KoksharovaEkaterina,et al.  The Relationship Between Brown Adipose Tissue Content in Supraclavicular Fat Depots and Insulin Sensitivity in Patients with Type 2 Diabetes Mellitus and Prediabetes. , 2017 .

[7]  P. Trayhurn Recruiting Brown Adipose Tissue in Human Obesity , 2016, Diabetes.

[8]  M. Budoff,et al.  Abdominal fat radiodensity, quantity and cardiometabolic risk: The Multi-Ethnic Study of Atherosclerosis. , 2016, Nutrition, metabolism, and cardiovascular diseases : NMCD.

[9]  W. Fenske,et al.  Differential effects of Roux-en-Y gastric bypass surgery on brown and beige adipose tissue thermogenesis. , 2015, Metabolism: clinical and experimental.

[10]  H. Pijl,et al.  Central GLP-1 receptor signalling accelerates plasma clearance of triacylglycerol and glucose by activating brown adipose tissue in mice , 2015, Diabetologia.

[11]  J. Orava,et al.  Brown adipose tissue triglyceride content is associated with decreased insulin sensitivity, independently of age and obesity , 2015, Diabetes, obesity & metabolism.

[12]  P. Iozzo,et al.  The effects of bariatric surgery on pancreatic lipid metabolism and blood flow. , 2015, The Journal of clinical endocrinology and metabolism.

[13]  A. Carpentier,et al.  Selective Impairment of Glucose but Not Fatty Acid or Oxidative Metabolism in Brown Adipose Tissue of Subjects With Type 2 Diabetes , 2015, Diabetes.

[14]  Y. Tseng,et al.  Brown fat fuel utilization and thermogenesis , 2014, Trends in Endocrinology & Metabolism.

[15]  A. Rissanen,et al.  Blunted metabolic responses to cold and insulin stimulation in brown adipose tissue of obese humans , 2013, Obesity.

[16]  Naser Ahmadi,et al.  Accurate detection of metabolically active "brown" and "white" adipose tissues with computed tomography. , 2013, Academic radiology.

[17]  S. Young,et al.  Biochemistry and pathophysiology of intravascular and intracellular lipolysis. , 2013, Genes & development.

[18]  A. Schürmann,et al.  Non-Invasive Quantification of White and Brown Adipose Tissues and Liver Fat Content by Computed Tomography in Mice , 2012, PloS one.

[19]  W D van Marken Lichtenbelt,et al.  Increase in brown adipose tissue activity after weight loss in morbidly obese subjects. , 2012, The Journal of clinical endocrinology and metabolism.

[20]  A. Carpentier,et al.  Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans. , 2012, The Journal of clinical investigation.

[21]  J. Orava,et al.  Different metabolic responses of human brown adipose tissue to activation by cold and insulin. , 2011, Cell metabolism.

[22]  W. D. van Marken Lichtenbelt,et al.  Brown Adipose Tissue in Morbidly Obese Subjects , 2011, PloS one.

[23]  Oliver T. Bruns,et al.  Brown adipose tissue activity controls triglyceride clearance , 2011, Nature Medicine.

[24]  R. Goodlad,et al.  Gut Hypertrophy After Gastric Bypass Is Associated With Increased Glucagon-Like Peptide 2 and Intestinal Crypt Cell Proliferation , 2010, Annals of surgery.

[25]  Hiroshi Honda,et al.  CT Hounsfield Units of Brown Adipose Tissue Increase with Activation: Preclinical and Clinical Studies , 2010, Journal of Nuclear Medicine.

[26]  W. D. van Marken Lichtenbelt,et al.  Cold-activated brown adipose tissue in healthy men. , 2009, The New England journal of medicine.

[27]  J. Orava,et al.  Functional brown adipose tissue in healthy adults. , 2009, The New England journal of medicine.

[28]  B. Spiegelman,et al.  PRDM16 controls a brown fat/skeletal muscle switch , 2008, Nature.

[29]  J. Levy,et al.  Use and abuse of HOMA modeling. , 2004, Diabetes care.

[30]  P. Iozzo,et al.  Liver uptake of free fatty acids in vivo in humans as determined with 14(R,S)-[18F]fluoro-6-thia-heptadecanoic acid and PET , 2003, European Journal of Nuclear Medicine and Molecular Imaging.

[31]  V. Oikonen,et al.  14(R,S)-[18F]Fluoro-6-thia-heptadecanoic acid as a tracer of free fatty acid uptake and oxidation in myocardium and skeletal muscle , 2002, European Journal of Nuclear Medicine and Molecular Imaging.

[32]  M. Stumvoll,et al.  Clinical features of insulin resistance and beta cell dysfunction and the relationship to type 2 diabetes. , 2001, Clinics in laboratory medicine.

[33]  K. Westerterp,et al.  Increase in fat oxidation on a high-fat diet is accompanied by an increase in triglyceride-derived fatty acid oxidation. , 2000, Diabetes.

[34]  M. Matsuda,et al.  Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. , 1999, Diabetes care.

[35]  P. Raskin,et al.  Report of the expert committee on the diagnosis and classification of diabetes mellitus. , 1999, Diabetes care.

[36]  R M Peshock,et al.  Relationship of Generalized and Regional Adiposity to Insulin Sensitivity in Men With NIDDM , 1996, Diabetes.

[37]  C. Patlak,et al.  Graphical Evaluation of Blood-to-Brain Transfer Constants from Multiple-Time Uptake Data. Generalizations , 1985, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[38]  K. Frayn,et al.  Calculation of substrate oxidation rates in vivo from gaseous exchange. , 1983, Journal of applied physiology: respiratory, environmental and exercise physiology.

[39]  C S Patlak,et al.  Graphical Evaluation of Blood-to-Brain Transfer Constants from Multiple-Time Uptake Data , 1983, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[40]  J. B. Weir New methods for calculating metabolic rate with special reference to protein metabolism , 1949, The Journal of physiology.

[41]  J. Murabito,et al.  Fat quality and incident cardiovascular disease, all-cause mortality, and cancer mortality. , 2015, The Journal of clinical endocrinology and metabolism.

[42]  Jan Nedergaard,et al.  Brown adipose tissue: function and physiological significance. , 2004, Physiological reviews.

[43]  Definition and Diagnosis of Diabetes Mellitus and Intermediate Hyperglycemia Report of a Who/idf Consultation Who Library Cataloguing-in-publication Data , 2022 .