A Novel Needle-Type SV-GMR Sensor for Biomedical Applications

Cancer is the most deadly disease in the world today. There is a variety of different treatment methods for cancer, including radiotherapy and chemotherapy with anticancer drugs that have been in use over a long period of time. Hyperthermia is one of the cancer treatment methods that utilizes the property that cancer cells are more sensitive to temperature than normal cells. The control of temperature is an important task in achieving success using this treatment method. This paper reports the development of a novel needle-type nanosensor based on the spin-valve giant magnetoresistive (SV-GMR) technique to measure the magnetic flux density inside the body via pricking the needle. The sensor has been fabricated. The modeling and experimental results of flux density measurement have been reported. From the information of flux density, the temperature rise can be estimated to permit the delivery of controlled heating to precisely defined locations in controlled hyperthermia cancer treatment. The actual experiment with human is under investigation

[1]  Q. Pankhurst,et al.  Applications of magnetic nanoparticles in biomedicine , 2003 .

[2]  S. Mukhopadhyay,et al.  A novel planar mesh-type microelectromagnetic sensor. Part I. Model formulation , 2004, IEEE Sensors Journal.

[3]  I. Nagano,et al.  Development of a Portable Inductive Heating System Using Dextran Magnetite Complex (DM) , 2003 .

[4]  Y Rabin,et al.  Is intracellular hyperthermia superior to extracellular hyperthermia in the thermal sense? , 2002, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[5]  W. Kaiser,et al.  Physical limits of hyperthermia using magnetite fine particles , 1998 .

[7]  S. Mukhopadhyay,et al.  A novel planar mesh-type microelectromagnetic sensor. Part II. Estimation of system properties , 2004, IEEE Sensors Journal.

[8]  Chinthaka P. Gooneratne,et al.  A low-cost sensing system for quality monitoring of dairy products , 2006, IEEE Transactions on Instrumentation and Measurement.

[9]  Costas P. Grigoropoulos,et al.  Noncontact nanosecond-time-resolution temperature measurement in excimer laser heating of Ni–P disk substrates , 1997 .

[10]  Waldemar Wlodarczyk,et al.  A practical approach to thermography in a hyperthermia/magnetic resonance hybrid system: validation in a heterogeneous phantom. , 2005, International journal of radiation oncology, biology, physics.

[11]  Catherine C. Berry,et al.  Functionalisation of magnetic nanoparticles for applications in biomedicine : Biomedical applications of magnetic nanoparticles , 2003 .

[12]  R. M. Arthur,et al.  Non-invasive estimation of hyperthermia temperatures with ultrasound , 2005, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.