论文信息 - Reductive opening of the thiazolidine ring. Selective N‐methylation of cysteamines - 字舞流文

Reductive opening of the thiazolidine ring. Selective N‐methylation of cysteamines

The reaction of thiazolidines 2 and 7 with borane was investigated. It gave N-methylcysteamines 3 and 8 through thiazolidine ring opening. Sodium borohydride and lithium aluminum hydride were ineffective.

C. Melchiorre | P. Angeli | D. Giardiná | Carlo Melchiorre

[1] C. Melchiorre,et al. Molecular properties of the adrenergic alpha receptor. 2. Optimum covalent inhibition by two different prototypes of polyamine disulfides. , 1978, Journal of Medicinal Chemistry.

[2] Ding-Djung H. Yang,et al. A New Synthesis of Cysteinyl Peptides1 , 1958 .

[3] I. R. Schmolka,et al. Thiazolidine Chemistry. III. The Preparation and Reduction of Some 2-Phenyl-3-n-alkyl-4-thiazolidinones1-3 , 1957 .

[4] T. C. Owen. Amino-alkanethiols from amino-alcohols via aminoalkyl sulphates and thiazolidinethiones. , 1967, Journal of the Chemical Society. Perkin transactions 1.

[5] S. Ratner,et al. The Action of Formaldehyde upon Cysteine , 1937 .

[6] G. M. Bennett. LII.—ββ′-Dichlorodiethyl disulphide , 1921 .