Accelerated Ovarian Failure: A novel, chemically induced animal model of menopause
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[1] P. Hoyer,et al. Inhibition of PIK3 Signaling Pathway Members by the Ovotoxicant 4-Vinylcyclohexene Diepoxide in Rats1 , 2011, Biology of reproduction.
[2] W. Rocca,et al. Oophorectomy, menopause, estrogen treatment, and cognitive aging: Clinical evidence for a window of opportunity , 2011, Brain Research.
[3] B. Nixon,et al. Adding insult to injury: effects of xenobiotic-induced preantral ovotoxicity on ovarian development and oocyte fusibility. , 2010, Toxicological sciences : an official journal of the Society of Toxicology.
[4] P. Hoyer,et al. Distribution and responsiveness of rat anti-Müllerian hormone during ovarian development and VCD-induced ovotoxicity. , 2010, Toxicology and applied pharmacology.
[5] L. McMahon,et al. Duration of estrogen deprivation, not chronological age, prevents estrogen's ability to enhance hippocampal synaptic physiology , 2010, Proceedings of the National Academy of Sciences.
[6] P. Hoyer,et al. Dual protective role for glutathione S-transferase class pi against VCD-induced ovotoxicity in the rat ovary. , 2010, Toxicology and applied pharmacology.
[7] H. Bimonte-Nelson,et al. The cognitive effects of conjugated equine estrogens depend on whether menopause etiology is transitional or surgical. , 2010, Endocrinology.
[8] J. Chervenak,et al. The continuum of ovarian aging and clinicopathologies associated with the menopausal transition. , 2010, Maturitas.
[9] K. Yoo,et al. Systemic Administration of Lipopolysaccharide Induces Cyclooxygenase-2 Immunoreactivity in Endothelium and Increases Microglia in the Mouse Hippocampus , 2010, Cellular and Molecular Neurobiology.
[10] J. Davis,et al. 7,12-dimethylbenz[a]anthracene induces sertoli-leydig-cell tumors in the follicle-depleted ovaries of mice treated with 4-vinylcyclohexene diepoxide. , 2010, Comparative medicine.
[11] W. Rocca,et al. Premature menopause or early menopause: long-term health consequences. , 2010, Maturitas.
[12] S. Davidge,et al. Ovariectomy in aged versus young rats augments matrix metalloproteinase-mediated vasoconstriction in mesenteric arteries , 2010, Menopause.
[13] P. Hoyer,et al. Effect of phosphatidylinositol-3 kinase inhibition on ovotoxicity caused by 4-vinylcyclohexene diepoxide and 7, 12-dimethylbenz[a]anthracene in neonatal rat ovaries. , 2009, Toxicology and applied pharmacology.
[14] P. Schmidt,et al. Sex Hormones and Mood in the Perimenopause , 2009, Annals of the New York Academy of Sciences.
[15] Craig K. Enders,et al. Transitional versus surgical menopause in a rodent model: etiology of ovarian hormone loss impacts memory and the acetylcholine system. , 2009, Endocrinology.
[16] P. Hoyer,et al. Loss of ovarian function in the VCD mouse-model of menopause leads to insulin resistance and a rapid progression into the metabolic syndrome. , 2009, American journal of physiology. Regulatory, integrative and comparative physiology.
[17] D. Rubinow,et al. Reproductive aging, sex steroids, and mood disorders. , 2009, Harvard review of psychiatry.
[18] T. Seeman,et al. Effects of the menopause transition and hormone use on cognitive performance in midlife women , 2009, Neurology.
[19] R. Wood,et al. Neuroprotection against excitotoxic brain injury in mice after ovarian steroid depletion , 2009, Brain Research.
[20] J. Barton,et al. Ovarian neoplasm development by 7,12-dimethylbenz[a]anthracene (DMBA) in a chemically-induced rat model of ovarian failure. , 2009, Gynecologic Oncology.
[21] P. Hoyer,et al. Steroidogenic Capacity of Residual Ovarian Tissue in 4-Vinylcyclohexene Diepoxide-Treated Mice1 , 2009, Biology of reproduction.
[22] P. Hoyer,et al. Effects of 4-vinylcyclohexene diepoxide on peripubertal and adult Sprague-Dawley rats: ovarian, clinical, and pathologic outcomes. , 2009, Comparative medicine.
[23] K. Frick. Estrogens and age-related memory decline in rodents: What have we learned and where do we go from here? , 2009, Hormones and Behavior.
[24] J. Visser,et al. Correlation of serum anti-Müllerian hormone with accelerated follicle loss following 4-vinylcyclohexene diepoxide-induced follicle loss in mice. , 2008, Reproductive toxicology.
[25] P. Hoyer,et al. Behavioral consequences of ovarian atrophy and estrogen replacement in the APPswe mouse , 2008, Neurobiology of Aging.
[26] B. McEwen,et al. Estrous cycle regulates activation of hippocampal Akt, LIM kinase, and neurotrophin receptors in C57BL/6 mice , 2008, Neuroscience.
[27] Randall L. Lindquist,et al. CD11c/EYFP transgene illuminates a discrete network of dendritic cells within the embryonic, neonatal, adult, and injured mouse brain , 2008, The Journal of comparative neurology.
[28] P. Hoyer,et al. Comparison of Skeletal Effects of Ovariectomy Versus Chemically Induced Ovarian Failure in Mice , 2008, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[29] P. Hoyer,et al. Effects of impending ovarian failure induced by 4-vinylcyclohexene diepoxide on fertility in C57BL/6 female mice. , 2007, Comparative medicine.
[30] F. Stanczyk,et al. Ovarian androgen production in postmenopausal women. , 2007, The Journal of clinical endocrinology and metabolism.
[31] P. Hoyer,et al. Hormonal status affects the progression of STZ-induced diabetes and diabetic renal damage in the VCD mouse model of menopause. , 2007, American journal of physiology. Renal physiology.
[32] P. Hoyer,et al. Development of an animal model for ovotoxicity using 4-vinylcyclohexene: a case study. , 2007, Birth defects research. Part B, Developmental and reproductive toxicology.
[33] S. Maier,et al. Microglia serve as a neuroimmune substrate for stress-induced potentiation of CNS pro-inflammatory cytokine responses , 2007, Brain, Behavior, and Immunity.
[34] A. Gore,et al. Age-related Changes in Hormones and Their Receptors in Animal Models of Female Reproductive Senescence , 2006 .
[35] J. Morrison,et al. Estrogen, Menopause, and the Aging Brain: How Basic Neuroscience Can Inform Hormone Therapy in Women , 2006, The Journal of Neuroscience.
[36] P. Hoyer,et al. Destruction of primordial ovarian follicles in adult cynomolgus macaques after exposure to 4-vinylcyclohexene diepoxide: a nonhuman primate model of the menopausal transition. , 2006, Fertility and sterility.
[37] D. Yurgelun-Todd,et al. Estrogen therapy selectively enhances prefrontal cognitive processes: a randomized, double-blind, placebo-controlled study with functional magnetic resonance imaging in perimenopausal and recently postmenopausal women , 2006, Menopause.
[38] P. Hoyer,et al. Effect of duration of dosing on onset of ovarian failure in a chemical-induced mouse model of perimenopause , 2006, Menopause.
[39] P. Maki. Hormone therapy and cognitive function: Is there a critical period for benefit? , 2006, Neuroscience.
[40] M. Sairam,et al. Recent female mouse models displaying advanced reproductive aging , 2006, Experimental Gerontology.
[41] P. Hoyer,et al. Characterization of cyclicity and hormonal profile with impending ovarian failure in a novel chemical-induced mouse model of perimenopause. , 2005, Comparative medicine.
[42] P. Hoyer,et al. Atherosclerotic Lesion Development in a Novel Ovary-Intact Mouse Model of Perimenopause , 2005, Arteriosclerosis, thrombosis, and vascular biology.
[43] J. K. Williams. A mouse model of the perimenopausal transition: importance for cardiovascular research. , 2005, Arteriosclerosis, thrombosis, and vascular biology.
[44] S. Davis,et al. Androgen levels in adult females: changes with age, menopause, and oophorectomy. , 2005, The Journal of clinical endocrinology and metabolism.
[45] R. Green,et al. Postmenopausal hormone therapy and Alzheimer’s disease risk: interaction with age , 2004, Journal of Neurology, Neurosurgery & Psychiatry.
[46] A. Gore,et al. Aging-Related Changes in Ovarian Hormones, Their Receptors, and Neuroendocrine Function , 2004, Experimental biology and medicine.
[47] P. Hoyer,et al. The Follicle-Deplete Mouse Ovary Produces Androgen1 , 2004, Biology of reproduction.
[48] P. Hoyer,et al. Expression and activity of cytochromes P450 2E1, 2A, and 2B in the mouse ovary: the effect of 4-vinylcyclohexene and its diepoxide metabolite. , 2003, Toxicological sciences : an official journal of the Society of Toxicology.
[49] B. Sherwin,et al. Estrogen and cognitive functioning in women. , 2003, Endocrine reviews.
[50] P. Zandi,et al. Hormone replacement therapy and incidence of Alzheimer disease in older women: The Cache County Study , 2003 .
[51] P. Zandi,et al. Hormone replacement therapy and incidence of Alzheimer disease in older women: the Cache County Study. , 2002, JAMA.
[52] P. Hoyer,et al. Characterization of a rat in vitro ovarian culture system to study the ovarian toxicant 4-vinylcyclohexene diepoxide. , 2002, Toxicology and applied pharmacology.
[53] J. Flaws,et al. Activation of Mitogen-Activated Protein Kinases and AP-1 Transcription Factor in Ovotoxicity Induced by 4-Vinylcyclohexene Diepoxide in Rats1 , 2002, Biology of reproduction.
[54] A. Gore,et al. Age‐Related Changes in Hypothalamic Gonadotropin‐Releasing Hormone and N‐Methyl‐d‐Aspartate Receptor Gene Expression, and their Regulation by Oestrogen, in the Female Rat , 2002, Journal of neuroendocrinology.
[55] P. Hoyer,et al. 17β-Estradiol Affords Protection against 4-Vinylcyclohexene Diepoxide-Induced Ovarian Follicle Loss in Fischer-344 Rats. , 2002, Endocrinology.
[56] P. Hoyer,et al. Expression and Redistribution of Cellular Bad, Bax, and Bcl-xL Protein Is Associated with VCD-Induced Ovotoxicity in Rats1 , 2001, Biology of reproduction.
[57] P. Hoyer,et al. Effect of 4-vinylcyclohexene diepoxide dosing in rats on GSH levels in liver and ovaries. , 2001, Toxicological sciences : an official journal of the Society of Toxicology.
[58] P. Hoyer,et al. Apoptosis Induced in Rats by 4-Vinylcyclohexene Diepoxide Is Associated with Activation of the Caspase Cascades1 , 2001, Biology of reproduction.
[59] P. Hoyer,et al. Ovarian Toxicity of 4-Vinylcyclohexene Diepoxide: A Mechanistic Model , 2001, Toxicologic pathology.
[60] B. Rubin. Hypothalamic Alterations and Reproductive Aging in Female Rats: Evidence of Altered Luteinizing Hormone-Releasing Hormone Neuronal Function1 , 2000, Biology of reproduction.
[61] E. Barrett-Connor,et al. Hysterectomy, oophorectomy, and endogenous sex hormone levels in older women: the Rancho Bernardo Study. , 2000, The Journal of clinical endocrinology and metabolism.
[62] P. Hoyer,et al. A single dose of the ovotoxicant 4-vinylcyclohexene diepoxide is protective in rat primary ovarian follicles. , 1999, Toxicology and applied pharmacology.
[63] P. Cohen,et al. Silastic implants for delivery of oestradiol to mice. , 1993, Journal of reproduction and fertility.
[64] D. Mattison,et al. The role of epoxidation in 4-vinylcyclohexene-induced ovarian toxicity. , 1990, Toxicology and applied pharmacology.
[65] P. Zandi,et al. Hormone Replacement Therapy and Incidence of Alzheimer Disease in Older Women , 2011 .
[66] K. Bradshaw,et al. The post-menopausal ovary displays a unique pattern of steroidogenic enzyme expression. , 2006, Human reproduction.
[67] M. Rousseau. Managing Menopausal Symptoms , 2006 .
[68] P. Wise,et al. Neuroendocrine modulation and repercussions of female reproductive aging. , 2002, Recent progress in hormone research.
[69] P. Hoyer,et al. Assessment of follicle destruction in chemical-induced ovarian toxicity. , 1996, Annual review of pharmacology and toxicology.