Bactericidal antibiotics promote reactive oxygen species formation and inflammation in human sinonasal epithelial cells

Bactericidal antibiotics have been shown to stimulate reactive oxygen species (ROS) formation in mammalian cells through mitochondrial dysfunction. This results in oxidative tissue damage that may have negative consequences for long‐term antibiotic use. Antibiotics are widely and heavily used in the treatment of acute and chronic sinusitis; however, the relationship between antibiotics and ROS formation in sinonasal epithelial cells (SNECs) has not yet been demonstrated.

[1]  Xiangmei Zhou,et al.  The role of mitochondria in NLRP3 inflammasome activation. , 2018, Molecular immunology.

[2]  S. Cullen,et al.  Diverse Activators of the NLRP3 Inflammasome Promote IL-1β Secretion by Triggering Necrosis. , 2015, Cell reports.

[3]  A. Lane,et al.  Sinonasal epithelial cell response to Staphylococcus aureus burden in chronic rhinosinusitis. , 2015, JAMA otolaryngology-- head & neck surgery.

[4]  D. Poetker,et al.  What rhinologists and allergists should know about the medico‐legal implications of antibiotic use: a review of the literature , 2015, International forum of allergy & rhinology.

[5]  Ahmad S. Khalil,et al.  Antibiotics induce redox-related physiological alterations as part of their lethality , 2014, Proceedings of the National Academy of Sciences.

[6]  R. Schlosser,et al.  Cytokine correlation between sinus tissue and nasal secretions among chronic rhinosinusitis and controls , 2013, The Laryngoscope.

[7]  Maria Markaki,et al.  Crosstalk between apoptosis, necrosis and autophagy. , 2013, Biochimica et biophysica acta.

[8]  C. Evans,et al.  National burden of antibiotic use for adult rhinosinusitis. , 2013, The Journal of allergy and clinical immunology.

[9]  J. Collins,et al.  Bactericidal Antibiotics Induce Mitochondrial Dysfunction and Oxidative Damage in Mammalian Cells , 2013, Science Translational Medicine.

[10]  E. Latz,et al.  Activation and regulation of the inflammasomes , 2013, Nature Reviews Immunology.

[11]  Q. Ma.  Role of nrf2 in oxidative stress and toxicity. , 2013, Annual review of pharmacology and toxicology.

[12]  Z. Soler,et al.  Antimicrobials and chronic rhinosinusitis with or without polyposis in adults: an evidenced‐based review with recommendations , 2013, International forum of allergy & rhinology.

[13]  M. Brynildsen,et al.  Potentiating antibacterial activity by predictably enhancing endogenous microbial ROS production , 2012, Nature Biotechnology.

[14]  Daniel J. Shapiro,et al.  National trends in visit rates and antibiotic prescribing for adults with acute sinusitis. , 2012, Archives of internal medicine.

[15]  Diogo M. Camacho,et al.  Antibiotic-induced bacterial cell death exhibits physiological and biochemical hallmarks of apoptosis. , 2012, Molecular cell.

[16]  James J Foti,et al.  Oxidation of the Guanine Nucleotide Pool Underlies Cell Death by Bactericidal Antibiotics , 2012, Science.

[17]  Rajarsi Mandal,et al.  Role of antibiotics in sinusitis , 2012, Current opinion in infectious diseases.

[18]  N. Bhattacharyya.  Incremental Health Care Utilization and Expenditures for Chronic Rhinosinusitis in the United States , 2011, The Annals of otology, rhinology, and laryngology.

[19]  B. Rubin,et al.  Mechanisms of Action and Clinical Application of Macrolides as Immunomodulatory Medications , 2010, Clinical Microbiology Reviews.

[20]  M. McMahon,et al.  p62/SQSTM1 Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription* , 2010, The Journal of Biological Chemistry.

[21]  M. DePristo,et al.  Sublethal antibiotic treatment leads to multidrug resistance via radical-induced mutagenesis. , 2010, Molecular cell.

[22]  Timothy L. Smith,et al.  What is the role of long‐term macrolide therapy in the treatment of recalcitrant chronic rhinosinusitis? , 2009, The Laryngoscope.

[23]  J. Turner,et al.  Technical advances in rhinologic basic science research. , 2009, Otolaryngologic clinics of North America.

[24]  J. Collins,et al.  Mistranslation of Membrane Proteins and Two-Component System Activation Trigger Antibiotic-Mediated Cell Death , 2008, Cell.

[25]  J. Collins,et al.  A Common Mechanism of Cellular Death Induced by Bactericidal Antibiotics , 2007, Cell.

[26]  Murugappan Ramanathan,et al.  A Comparison of Experimental Methods in Molecular Chronic Rhinosinusitis Research , 2007, American journal of rhinology.

[27]  Murugappan Ramanathan,et al.  Innate immunity of the sinonasal cavity and its role in chronic rhinosinusitis , 2007, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[28]  V. Lund.  Maximal medical therapy for chronic rhinosinusitis. , 2005, Otolaryngologic clinics of North America.

[29]  J. Turrens,et al.  Mitochondrial formation of reactive oxygen species , 2003, The Journal of physiology.

[30]  Z. Yasruel,et al.  Evidence for distinct cytokine expression in allergic versus nonallergic chronic sinusitis. , 1995, The Journal of allergy and clinical immunology.

[31]  R. Davies,et al.  Effect of Haemophilus influenzae endotoxin on the synthesis of IL-6, IL-8, TNF-alpha and expression of ICAM-1 in cultured human bronchial epithelial cells. , 1994, The European respiratory journal.

[32]  M. Kagnoff,et al.  Epithelial cells secrete the chemokine interleukin-8 in response to bacterial entry , 1993, Infection and immunity.

[33]  E. Latz,et al.  New insights into mechanisms controlling the NLRP3 inflammasome and its role in lung disease. , 2014, The American journal of pathology.

[34]  B. Hayete,et al.  Gyrase inhibitors induce an oxidative damage cellular death pathway in Escherichia coli , 2007, Molecular systems biology.