Prevention of microgliosis halts early memory loss in a mouse model of Alzheimer’s disease
暂无分享,去创建一个
A. Smit | J. Middeldorp | M. Verheijen | B. Eggen | T. Oshima | Christiaan F M Huffels | M. Kater | Niek S. Renckens | Erik W.G.M. Boddeke | E. Hol | Christiaan F. M. Huffels | Mandy S J Kater | Mandy S. J. Kater
[1] E. Hol,et al. Amyloid‐β plaques affect astrocyte Kir4.1 protein expression but not function in the dentate gyrus of APP/PS1 mice , 2022, Glia.
[2] Laurent F. Thomas,et al. A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer’s disease , 2021, Nature Genetics.
[3] I. Bechmann,et al. Classification of Microglial Morphological Phenotypes Using Machine Learning , 2021, Frontiers in Cellular Neuroscience.
[4] A. Nimmerjahn,et al. Microglia use TAM receptors to detect and engulf amyloid beta plaques , 2021, Nature Immunology.
[5] D. Borchelt,et al. Reactive astrocytes as treatment targets in Alzheimer's disease—Systematic review of studies using the APPswePS1dE9 mouse model , 2021, Glia.
[6] J. Mulder,et al. Distinct amyloid-β and tau-associated microglia profiles in Alzheimer’s disease , 2021, Acta Neuropathologica.
[7] B. Eggen,et al. Intrinsic DNA damage repair deficiency results in progressive microglia loss and replacement , 2020, Glia.
[8] D. Shippy,et al. Microglial Immunometabolism in Alzheimer’s Disease , 2020, Frontiers in Cellular Neuroscience.
[9] N. Harrison,et al. Minocycline differentially modulates human spatial memory systems , 2020, Neuropsychopharmacology.
[10] Jie Li,et al. Microglia mediate forgetting via complement-dependent synaptic elimination , 2020, Science.
[11] S. Reeves,et al. Minocycline at 2 Different Dosages vs Placebo for Patients With Mild Alzheimer Disease , 2019, JAMA neurology.
[12] Caroline L C Neely,et al. Nest Building Behavior as an Early Indicator of Behavioral Deficits in Mice. , 2019, Journal of visualized experiments : JoVE.
[13] I. Heuser,et al. Minocycline alters behavior, microglia and the gut microbiome in a trait-anxiety-dependent manner , 2019, Translational Psychiatry.
[14] P. Scheltens,et al. Early restoration of parvalbumin interneuron activity prevents memory loss and network hyperexcitability in a mouse model of Alzheimer’s disease , 2019, Molecular Psychiatry.
[15] H. Mansvelder,et al. Gpr158 Deficiency Impacts Hippocampal CA1 Neuronal Excitability, Dendritic Architecture, and Affects Spatial Learning , 2018, bioRxiv.
[16] B. Stevens,et al. Microglia and the Brain: Complementary Partners in Development and Disease. , 2018, Annual review of cell and developmental biology.
[17] B. Eggen,et al. The Kaleidoscope of Microglial Phenotypes , 2018, Front. Immunol..
[18] P. Scheltens,et al. Neuropathology and cognitive performance in self-reported cognitively healthy centenarians , 2018, Acta neuropathologica communications.
[19] Sterling C. Johnson,et al. Neurodegeneration, synaptic dysfunction, and gliosis are phenotypic of Alzheimer dementia , 2018, Neurology.
[20] B. Winblad,et al. APP mouse models for Alzheimer's disease preclinical studies , 2017, The EMBO journal.
[21] Beth Stevens,et al. Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice , 2017, Science Translational Medicine.
[22] P. Brust,et al. Maternal immune activation results in complex microglial transcriptome signature in the adult offspring that is reversed by minocycline treatment , 2017, Translational Psychiatry.
[23] Yanbo Zhang,et al. The role of neuroinflammation and amyloid in cognitive impairment in an APP/PS1 transgenic mouse model of Alzheimer's disease , 2017, CNS neuroscience & therapeutics.
[24] E. Hol,et al. Transcriptional profiling of CD11c-positive microglia accumulating around amyloid plaques in a mouse model for Alzheimer's disease. , 2016, Biochimica et biophysica acta.
[25] A. Fischer,et al. Ly6C(hi) Monocytes Provide a Link between Antibiotic-Induced Changes in Gut Microbiota and Adult Hippocampal Neurogenesis. , 2016, Cell reports.
[26] Ben A. Barres,et al. Complement and microglia mediate early synapse loss in Alzheimer mouse models , 2016, Science.
[27] Eric Karran,et al. The Cellular Phase of Alzheimer’s Disease , 2016, Cell.
[28] O. Heikal,et al. Minocycline attenuates Aβ oligomers-induced pro-inflammatory phenotype in primary microglia while enhancing Aβ fibrils phagocytosis , 2015, Neuroscience Letters.
[29] Emmeke Aarts,et al. The light spot test: Measuring anxiety in mice in an automated home-cage environment , 2015, Behavioural Brain Research.
[30] Jeremy A. Miller,et al. Induction of a common microglia gene expression signature by aging and neurodegenerative conditions: a co-expression meta-analysis , 2015, Acta Neuropathologica Communications.
[31] V. Perry,et al. Microglial Dynamics and Role in the Healthy and Diseased Brain , 2015, The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry.
[32] L. Tan,et al. Role of pro-inflammatory cytokines released from microglia in Alzheimer's disease. , 2015, Annals of translational medicine.
[33] E. Weeber,et al. Slingshot-Cofilin activation mediates mitochondrial and synaptic dysfunction via Aβ ligation to β1-integrin conformers , 2015, Cell Death and Differentiation.
[34] E. Hol,et al. Isolation of glia from Alzheimer's mice reveals inflammation and dysfunction , 2014, Neurobiology of Aging.
[35] C. Eroglu,et al. Rapid Golgi Analysis Method for Efficient and Unbiased Classification of Dendritic Spines , 2014, PloS one.
[36] M. Lynch,et al. Modulation of Intestinal Microbiota by the Probiotic VSL#3 Resets Brain Gene Expression and Ameliorates the Age-Related Deficit in LTP , 2014, PloS one.
[37] H. Mansvelder,et al. Reducing hippocampal extracellular matrix reverses early memory deficits in a mouse model of Alzheimer’s disease , 2014, Acta neuropathologica communications.
[38] Deacon Rmj. A Novel Approach to Discovering Treatments for Alzheimer's Disease , 2014 .
[39] Joseph P. Garner,et al. Nest Building as an Indicator of Health and Welfare in Laboratory Mice , 2013, Journal of visualized experiments : JoVE.
[40] Val Lowe,et al. Dissecting phenotypic traits linked to human resilience to Alzheimer's pathology. , 2013, Brain : a journal of neurology.
[41] F. Kirchhoff,et al. Microglia: New Roles for the Synaptic Stripper , 2013, Neuron.
[42] Paul Edison,et al. Drug repositioning for Alzheimer's disease , 2012, Nature Reviews Drug Discovery.
[43] H. Steinbusch,et al. Mutant ubiquitin decreases amyloid β plaque formation in a transgenic mouse model of Alzheimer’s disease , 2012, Neurochemistry International.
[44] Ming-gao Zhao,et al. Involvement of Microglia Activation in the Lead Induced Long-Term Potentiation Impairment , 2012, PloS one.
[45] Ben A. Barres,et al. Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner , 2012, Neuron.
[46] O. Lindvall,et al. Inhibition of Microglial Activation Protects Hippocampal Neurogenesis and Improves Cognitive Deficits in a Transgenic Mouse Model for Alzheimer’s Disease , 2012, Neurodegenerative Diseases.
[47] M. Ferretti,et al. Minocycline corrects early, pre-plaque neuroinflammation and inhibits BACE-1 in a transgenic model of Alzheimer's disease-like amyloid pathology , 2012, Journal of Neuroinflammation.
[48] E. Hol,et al. Differential cell proliferation in the cortex of the appsweps1de9 alzheimer's disease mouse model , 2012, Glia.
[49] A. Nimmerjahn,et al. The Role of Microglia in the Healthy Brain , 2011, The Journal of Neuroscience.
[50] J. DeFelipe,et al. Layer‐specific alterations to CA1 dendritic spines in a mouse model of Alzheimer's disease , 2011, Hippocampus.
[51] M. Giustetto,et al. Synaptic Pruning by Microglia Is Necessary for Normal Brain Development , 2011, Science.
[52] Hélène Marie,et al. Hippocampal synaptic plasticity in Alzheimer's disease: what have we learned so far from transgenic models? , 2011, Alzheimer's & Dementia.
[53] H. Marie,et al. Hippocampal synaptic plasticity in Alzheimer's disease: what have we learned so far from transgenic models? , 2011, Alzheimer's & Dementia.
[54] M. Lynch,et al. Adenosine A2A receptors control neuroinflammation and consequent hippocampal neuronal dysfunction , 2011, Journal of neurochemistry.
[55] M. Jensen,et al. Episodic memory deficits are not related to altered glutamatergic synaptic transmission and plasticity in the CA1 hippocampus of the APPswe/PS1ΔE9-deleted transgenic mice model of β-amyloidosis , 2010, Neurobiology of Aging.
[56] G. Landreth,et al. The role of microglia in amyloid clearance from the AD brain , 2010, Journal of Neural Transmission.
[57] Y. Antonenko,et al. Minocycline chelates Ca2+, binds to membranes, and depolarizes mitochondria by formation of Ca2+-dependent ion channels , 2010, Journal of bioenergetics and biomembranes.
[58] S. Rivest,et al. Cognitive and non‐cognitive behaviors in an APPswe/PS1 bigenic model of Alzheimer’s disease , 2009, Genes, brain, and behavior.
[59] J. Koistinaho,et al. Minocycline reduces engraftment and activation of bone marrow‐derived cells but sustains their phagocytic activity in a mouse model of Alzheimer's disease , 2008, Glia.
[60] M. Block,et al. Retinoic Acid Attenuates β-Amyloid Deposition and Rescues Memory Deficits in an Alzheimer's Disease Transgenic Mouse Model , 2008, The Journal of Neuroscience.
[61] J. Rawlins,et al. Age-dependent and -independent behavioral deficits in Tg2576 mice , 2008, Behavioural Brain Research.
[62] J. Deleo,et al. Minocycline decreases in vitro microglial motility, β1‐integrin, and Kv1.3 channel expression , 2007, Journal of neurochemistry.
[63] Yoo-Hun Suh,et al. Minocycline Attenuates Neuronal Cell Death and Improves Cognitive Impairment in Alzheimer's Disease Models , 2007, Neuropsychopharmacology.
[64] Judianne Davis,et al. Minocycline Reduces Microglial Activation and Improves Behavioral Deficits in a Transgenic Model of Cerebral Microvascular Amyloid , 2007, The Journal of Neuroscience.
[65] A. Bessis,et al. Microglial control of neuronal death and synaptic properties , 2007, Glia.
[66] M. Lynch,et al. The age‐related attenuation in long‐term potentiation is associated with microglial activation , 2006, Journal of neurochemistry.
[67] R. Deacon. Assessing nest building in mice , 2006, Nature Protocols.
[68] F. Schmitt,et al. Hippocampal synaptic loss in early Alzheimer's disease and mild cognitive impairment , 2006, Neurobiology of Aging.
[69] C. Lemere,et al. Minocycline affects microglia activation, Aβ deposition, and behavior in APP‐tg mice , 2006, Glia.
[70] Mark Bowlby,et al. Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer's disease. , 2006, Proceedings of the National Academy of Sciences of the United States of America.
[71] R. Veerhuis,et al. Inhibitory effect of minocycline on amyloid β fibril formation and human microglial activation , 2006, Glia.
[72] R. Anwyl,et al. β‐amyloid inhibition of long‐term potentiation is mediated via tumor necrosis factor , 2005 .
[73] J. Brotchi,et al. Clinical potential of minocycline for neurodegenerative disorders , 2004, Neurobiology of Disease.
[74] C. Power,et al. For Personal Use. Only Reproduce with Permission from Elsevier Ltd Minocycline and Neurological Diseases Minocycline in Animal Models the Promise of Minocycline in Neurology , 2022 .
[75] D. Borchelt,et al. APP processing and amyloid deposition in mice haplo-insufficient for presenilin 1 , 2004, Neurobiology of Aging.
[76] Robert A Edwards,et al. Visible fluorescent detection of proteins in polyacrylamide gels without staining. , 2004, Analytical biochemistry.
[77] S. Weggen,et al. Evidence That Nonsteroidal Anti-inflammatory Drugs Decrease Amyloid β42 Production by Direct Modulation of γ-Secretase Activity* , 2003, Journal of Biological Chemistry.
[78] J. Rawlins,et al. Hippocampal cytotoxic lesion effects on species-typical behaviours in mice , 2002, Behavioural Brain Research.
[79] George A. Carlson,et al. The Relationship between Aβ and Memory in the Tg2576 Mouse Model of Alzheimer's Disease , 2002, The Journal of Neuroscience.
[80] Max A. Viergever,et al. Quantitative evaluation of convolution-based methods for medical image interpolation , 2001, Medical Image Anal..
[81] D. Salmon,et al. Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment , 1991, Annals of neurology.
[82] M. Reivich,et al. ACTIVATION , 1980, The Social Value of Zoos.
[83] A. Bacci,et al. Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease , 2011, Nature Neuroscience.
[84] D. Selkoe. Alzheimer's disease. , 2011, Cold Spring Harbor perspectives in biology.
[85] F. LaFerla,et al. Reductions in amyloid-beta-derived neuroinflammation, with minocycline, restore cognition but do not significantly affect tau hyperphosphorylation. , 2010, Journal of Alzheimer's disease : JAD.
[86] F. LaFerla,et al. Alzheimer's disease. , 2010, The New England journal of medicine.
[87] J. Zeman,et al. quantitative evaluation of by , 2010 .
[88] E. Bedel. Relationship between , 2009 .
[89] S. Weggen,et al. Evidence that nonsteroidal anti-inflammatory drugs decrease amyloid beta 42 production by direct modulation of gamma-secretase activity. , 2003, The Journal of biological chemistry.