Expression and Cell Distribution of Group I and Group II Metabotropic Glutamate Receptor Subtypes in Taylor‐type Focal Cortical Dysplasia

Summary:  Purpose: Focal cortical dysplasia (FCD) is known to be a major cause of intractable epilepsy. The cellular mechanism(s) underlying the epileptogenicity of FCD remain largely unknown. Because recent studies indicate that metabotropic glutamate receptor subtypes (mGluRs) play a role in epileptogenesis, we investigated the expression and cellular distribution pattern of mGluRs in FCD specimens.

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