论文信息 - Enhancement of Ia-like antigen expression by interferon-gamma in polymorphonuclear leukocytes.

Enhancement of Ia-like antigen expression by interferon-gamma in polymorphonuclear leukocytes.

The effects of interferons (IFNs) on Ia-like antigen expression in human peripheral blood polymorphonuclear leukocytes (PMNs) were examined in vitro using flow cytometry and FITC-labelled monoclonal antibody specific for the Ia-like antigen OKIa1. Recombinant human IFN-gamma markedly enhanced the expression of Ia-like antigen on PMNs and increased the number of Ia-positive PMNs. In contrast, natural human IFN-alpha and-beta had no effect on the expression when compared on the basis of antiviral activity.

M. Takei | M. Moriyama | H. Imanishi | S. Matsumoto

[1] T. Merigan,et al. Regulation of expression of class II major histocompatibility antigens on human peripheral blood monocytes and Langerhans cells by interferon. , 1984, Human immunology.