Increased high‐density lipoprotein cholesterol concentration in alcoholics is related to low cholesteryl ester transfer protein activity

Abstract. Cholesteryl ester transfer protein (CETP) facilitates the transfer of cholesteryl esters from HDL to apo B‐containing lipoproteins. Since alcoholics have high HDL cholesterol and low LDL cholesterol levels, a defect in cholesteryl ester transfer could be responsible for the alcohol‐induced alteration in cholesterol distribution between lipoproteins. To test this hypothesis, we compared CETP activity in plasma from 30 alcoholics without severe liver damage and 16 control subjects.

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