The problem of functional localization in the human brain

Functional imaging gives us increasingly detailed information about the location of brain activity. To use this information, we need a clear conception of the meaning of location data. Here, we review methods for reporting location in functional imaging and discuss the problems that arise from the great variability in brain anatomy between individuals. These problems cause uncertainty in localization, which limits the effective resolution of functional imaging, especially for brain areas involved in higher cognitive function.

[1]  G. Smith,et al.  Die Cytoarchitektonik der Hirnrinde des erwachsenen Menschen. , 1927 .

[2]  K. Brodmann.  Vergleichende Lokalisationslehre der Großhirnrinde : in ihren Prinzipien dargestellt auf Grund des Zellenbaues , 1985 .

[3]  T. Yuasa,et al.  Joseph's disease: Clinical and pathological studies in a Japanese family , 1986, Annals of neurology.

[4]  M. Torrens.  Co-Planar Stereotaxic Atlas of the Human Brain—3-Dimensional Proportional System: An Approach to Cerebral Imaging, J. Talairach, P. Tournoux. Georg Thieme Verlag, New York (1988), 122 pp., 130 figs. DM 268 , 1990 .

[5]  小野 道夫,et al.  Atlas of the Cerebral Sulci , 1990 .

[6]  이기수,et al.  II. , 1992 .

[7]  Alan C. Evans,et al.  Anatomical mapping of functional activation in stereotactic coordinate space , 1992, NeuroImage.

[8]  Alan C. Evans,et al.  An MRI-based stereotactic atlas from 250 young normal subjects , 1992 .

[9]  Richard S. J. Frackowiak,et al.  Area V5 of the human brain: evidence from a combined study using positron emission tomography and magnetic resonance imaging. , 1993, Cerebral cortex.

[10]  Manish S. Shah,et al.  A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes , 1993, Cell.

[11]  J. Kaas,et al.  Tonotopic organization, architectonic fields, and connections of auditory cortex in macaque monkeys , 1993, The Journal of comparative neurology.

[12]  A. Galaburda,et al.  Topographical variation of the human primary cortices: implications for neuroimaging, brain mapping, and neurobiology. , 1993, Cerebral cortex.

[13]  S. Benzer,et al.  Defective Glia in the Drosophila Brain Degeneration Mutant drop-dead , 1993, Neuron.

[14]  K. Zilles,et al.  Brain atlases - a new research tool , 1994, Trends in Neurosciences.

[15]  D. Collins,et al.  Automatic 3D Intersubject Registration of MR Volumetric Data in Standardized Talairach Space , 1994, Journal of computer assisted tomography.

[16]  S. Prusiner,et al.  Expression and targeting of Syrian hamster prion protein induced by heat shock in transgenic Drosophila melanogaster , 1995, Mechanisms of Development.

[17]  P. Goldman-Rakic,et al.  Cytoarchitectonic definition of prefrontal areas in the normal human cortex: II. Variability in locations of areas 9 and 46 and relationship to the Talairach Coordinate System. , 1995, Cerebral cortex.

[18]  J. Weissenbach,et al.  Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia , 1996, Nature.

[19]  S. Narumiya,et al.  Expanded polyglutamine in the Machado–Joseph disease protein induces cell death in vitro and in vivo , 1996, Nature Genetics.

[20]  K. Zilles,et al.  The calcarine sulcus as an estimate of the total volume of human striate cortex: a morphometric study of reliability and intersubject variability. , 1996, Journal fur Hirnforschung.

[21]  Karl J. Friston,et al.  Detecting Activations in PET and fMRI: Levels of Inference and Power , 1996, NeuroImage.

[22]  R. J. Frank,et al.  Reliability of PET activation across statistical methods, subject groups, and sample sizes , 1996, Human brain mapping.

[23]  Gwen A. Jacobs,et al.  Analysis of Information Processing in the Nervous System Using a Database of Identified Neurons , 1996, NeuroImage.

[24]  Daniel S. O'Leary,et al.  Sample Size and Statistical Power in [15O]H2O Studies of Human Cognition , 1996, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[25]  Alan C. Evans,et al.  Interhemispheric anatomical differences in human primary auditory cortex: probabilistic mapping and volume measurement from magnetic resonance scans. , 1996, Cerebral cortex.

[26]  S. Benzer,et al.  Spongecake and eggroll: two hereditary diseases in Drosophila resemble patterns of human brain degeneration , 1997, Current Biology.

[27]  K J Worsley,et al.  An overview and some new developments in the statistical analysis of PET and fMRI data , 1997, Human brain mapping.

[28]  N. Perrimon,et al.  A genetic screen for mutations that disrupt an auditory response in Drosophila melanogaster. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[29]  S. Benzer,et al.  The Swiss Cheese Mutant Causes Glial Hyperwrapping and Brain Degeneration in Drosophila , 1997, The Journal of Neuroscience.

[30]  A. Schleicher,et al.  The Somatosensory Cortex of Human: Cytoarchitecture and Regional Distributions of Receptor-Binding Sites , 1997, NeuroImage.

[31]  A. Schleicher,et al.  Cytoarchitectural maps of the human brain in standard anatomical space , 1997, Human brain mapping.

[32]  S. Clarke,et al.  Cytochrome Oxidase, Acetylcholinesterase, and NADPH-Diaphorase Staining in Human Supratemporal and Insular Cortex: Evidence for Multiple Auditory Areas , 1997, NeuroImage.

[33]  N. Kanwisher,et al.  The Fusiform Face Area: A Module in Human Extrastriate Cortex Specialized for Face Perception , 1997, The Journal of Neuroscience.

[34]  S. W. Davies,et al.  Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain. , 1997, Science.

[35]  Scott T. Grafton,et al.  Automated image registration: II. Intersubject validation of linear and nonlinear models. , 1998, Journal of computer assisted tomography.

[36]  Nancy M Bonini,et al.  Expanded Polyglutamine Protein Forms Nuclear Inclusions and Causes Neural Degeneration in Drosophila , 1998, Cell.

[37]  T Schormann,et al.  Three‐Dimensional linear and nonlinear transformations: An integration of light microscopical and MRI data , 1998, Human brain mapping.

[38]  K. Zilles,et al.  Structural divisions and functional fields in the human cerebral cortex 1 Published on the World Wide Web on 20 February 1998. 1 , 1998, Brain Research Reviews.

[39]  Nancy Kanwisher,et al.  A cortical representation of the local visual environment , 1998, Nature.

[40]  H. Steller,et al.  Blocking apoptosis prevents blindness in Drosophila retinal degeneration mutants , 1998, Nature.

[41]  L. Parsons,et al.  Beyond the single study: function/location metanalysis in cognitive neuroimaging , 1998, Current Opinion in Neurobiology.

[42]  Iris Salecker,et al.  Polyglutamine-Expanded Human Huntingtin Transgenes Induce Degeneration of Drosophila Photoreceptor Neurons , 1998, Neuron.

[43]  S. Minoshima,et al.  Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism , 1998, Nature.

[44]  Karen Faith Berman,et al.  Mapping Voxel-Based Statistical Power on Parametric Images , 1998, NeuroImage.

[45]  A. Dale,et al.  High‐resolution intersubject averaging and a coordinate system for the cortical surface , 1999, Human brain mapping.

[46]  J. Ashburner,et al.  Nonlinear spatial normalization using basis functions , 1999, Human brain mapping.

[47]  Thomas E. Nichols,et al.  Statistical limitations in functional neuroimaging. II. Signal detection and statistical inference. , 1999, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[48]  A. Schleicher,et al.  Broca's region revisited: Cytoarchitecture and intersubject variability , 1999, The Journal of comparative neurology.

[49]  A. Schleicher,et al.  Areas 3a, 3b, and 1 of Human Primary Somatosensory Cortex 1. Microstructural Organization and Interindividual Variability , 1999, NeuroImage.

[50]  S. Benzer,et al.  Preventing neurodegeneration in the Drosophila mutant bubblegum. , 1999, Science.

[51]  Russell A. Epstein,et al.  The Parahippocampal Place Area Recognition, Navigation, or Encoding? , 1999, Neuron.

[52]  R. Wanders,et al.  Progression of abnormalities in adrenomyeloneuropathy and neurologically asymptomatic X-linked adrenoleukodystrophy despite treatment with “Lorenzo’s oil” , 1999, Journal of neurology, neurosurgery, and psychiatry.

[53]  P. Jezzard,et al.  Sources of distortion in functional MRI data , 1999, Human brain mapping.

[54]  A. Dale,et al.  Cortical Surface-Based Analysis II: Inflation, Flattening, and a Surface-Based Coordinate System , 1999, NeuroImage.

[55]  P. S. St George-Hyslop,et al.  Expression of human FALS SOD in motorneurons of Drosophila. , 1999, Free radical biology & medicine.

[56]  M. Raichle,et al.  Tracking neuronal fiber pathways in the living human brain. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[57]  K. Zilles,et al.  t Object Shape Differences Reflected by Somatosensory Cortical Activation , 2000, The Journal of Neuroscience.

[58]  Paul M. Thompson,et al.  Warping strategies for intersubject registration , 2000 .

[59]  K. Amunts,et al.  Brodmann's Areas 17 and 18 Brought into Stereotaxic Space—Where and How Variable? , 2000, NeuroImage.

[60]  R. Woods,et al.  Mathematical/computational challenges in creating deformable and probabilistic atlases of the human brain , 2000, Human brain mapping.

[61]  Roger P. Woods.  Validation of registration accuracy , 2000 .

[62]  K. Amunts,et al.  Broca's region subserves imagery of motion: A combined cytoarchitectonic and fMRI study , 2000, Human brain mapping.

[63]  Newell,et al.  A neural basis for general intelligence , 2000, American journal of ophthalmology-glaucoma.

[64]  K. Zilles,et al.  Areas 3a, 3b, and 1 of Human Primary Somatosensory Cortex 2. Spatial Normalization to Standard Anatomical Space , 2000, NeuroImage.

[65]  James F. Gusella,et al.  Molecular genetics: Unmasking polyglutamine triggers in neurodegenerative disease , 2000, Nature Reviews Neuroscience.

[66]  J. Duncan,et al.  Common regions of the human frontal lobe recruited by diverse cognitive demands , 2000, Trends in Neurosciences.

[67]  René Hen,et al.  Reversal of Neuropathology and Motor Dysfunction in a Conditional Model of Huntington's Disease , 2000, Cell.

[68]  H. Zoghbi,et al.  Identification of genes that modify ataxin-1-induced neurodegeneration , 2000, Nature.

[69]  T. Yoshiura,et al.  Heschl and superior temporal gyri: low signal intensity of the cortex on T2-weighted MR images of the normal brain. , 2000, Radiology.

[70]  H. Theisen,et al.  Expanded polyglutamine peptides alone are intrinsically cytotoxic and cause neurodegeneration in Drosophila. , 2000, Human molecular genetics.

[71]  J L Lancaster,et al.  Automated Talairach Atlas labels for functional brain mapping , 2000, Human brain mapping.

[72]  Marc Joliot,et al.  Biological underpinnings of anatomic consistency and variability in the human brain , 2000 .

[73]  J. Gabrieli,et al.  The frontopolar cortex and human cognition: Evidence for a rostrocaudal hierarchical organization within the human prefrontal cortex , 2000, Psychobiology.

[74]  Dae-Shik Kim,et al.  Spatiotemporal dynamics of the BOLD fMRI signals: Toward mapping submillimeter cortical columns using the early negative response , 2000, Magnetic resonance in medicine.

[75]  Adrian M. Owen,et al.  The role of the lateral frontal cortex in mnemonic processing: the contribution of functional neuroimaging , 2000, Experimental Brain Research.

[76]  B. Postle,et al.  Prefrontal cortical contributions to working memory: evidence from event-related fMRI studies , 2000, Experimental Brain Research.

[77]  G. Pearlson,et al.  In vivo visualization of human neural pathways by magnetic resonance imaging , 2000, Annals of neurology.

[78]  J. Kaas,et al.  Subdivisions of auditory cortex and processing streams in primates. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[79]  H. Paulson,et al.  Mechanisms of chaperone suppression of polyglutamine disease: selectivity, synergy and modulation of protein solubility in Drosophila. , 2000, Human molecular genetics.

[80]  S. Benzer,et al.  Genetic suppression of polyglutamine toxicity in Drosophila. , 2000, Science.

[81]  Newell,et al.  A neural basis for general intelligence , 2000, American journal of ophthalmology.

[82]  K. Fischbeck,et al.  CREB-binding protein sequestration by expanded polyglutamine. , 2000, Human molecular genetics.

[83]  G J Barker,et al.  Combined functional magnetic resonance imaging and diffusion tensor imaging demonstrate widespread modified organisation in malformation of cortical development , 2001, Journal of neurology, neurosurgery, and psychiatry.

[84]  John Q. Trojanowski,et al.  Chaperone Suppression of α-Synuclein Toxicity in a Drosophila Model for Parkinson's Disease , 2001, Science.

[85]  Benjamin H. White,et al.  A conditional tissue-specific transgene expression system using inducible GAL4 , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[86]  Thomas C. Südhof,et al.  A Transcriptively Active Complex of APP with Fe65 and Histone Acetyltransferase Tip60 , 2001, Science.

[87]  N. Kanwisher,et al.  The Human Body , 2001 .

[88]  R. Zatorre,et al.  Spectral and temporal processing in human auditory cortex. , 2001, Cerebral cortex.

[89]  A. Fenster.  Handbook of Medical Imaging, Processing and Analysis , 2001 .

[90]  R. Nitsch,et al.  Formation of Neurofibrillary Tangles in P301L Tau Transgenic Mice Induced by Aβ42 Fibrils , 2001, Science.

[91]  J. Rademacher,et al.  Variability and asymmetry in the human precentral motor system. A cytoarchitectonic and myeloarchitectonic brain mapping study. , 2001, Brain : a journal of neurology.

[92]  Ravi S. Menon,et al.  Brief visual stimulation allows mapping of ocular dominance in visual cortex using fMRI , 2001, Human brain mapping.

[93]  J. Lancaster,et al.  Using the talairach atlas with the MNI template , 2001, NeuroImage.

[94]  P. Morosan,et al.  Probabilistic Mapping and Volume Measurement of Human Primary Auditory Cortex , 2001, NeuroImage.

[95]  K. Amunts,et al.  Advances in cytoarchitectonic mapping of the human cerebral cortex. , 2001, Neuroimaging clinics of North America.

[96]  Rhodri Cusack,et al.  Cytoarchitectonic region-of-interest analysis of auditory imaging data , 2001, NeuroImage.

[97]  P. Morosan,et al.  Human Primary Auditory Cortex: Cytoarchitectonic Subdivisions and Mapping into a Spatial Reference System , 2001, NeuroImage.

[98]  W. Hillen,et al.  Tetracycline-inducible systems for Drosophila , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[99]  J. Hardy,et al.  Enhanced Neurofibrillary Degeneration in Transgenic Mice Expressing Mutant Tau and APP , 2001, Science.

[100]  Robert Allen,et al.  Handbook of Medical Imaging—Processing and Analysis , 2001 .

[101]  Jon H Kaas,et al.  The organization of sensory cortex , 2001, Current Opinion in Neurobiology.

[102]  P. Chance,et al.  Molecular pathogenesis of hereditary motor, sensory and autonomic neuropathies , 2001, Current opinion in neurology.

[103]  K. E. Stephan,et al.  Multimodal characterisation of cortical areas by multivariate analyses of receptor binding and connectivity data , 2001, Anatomy and Embryology.

[104]  Isaac N. Bankman,et al.  Handbook of Medical Imaging. Processing and Analysis , 2002 .

[105]  A. Palmer,et al.  Histochemical identification of cortical areas in the auditory region of the human brain , 2002, Experimental Brain Research.