Long term results of unilateral posteroventral pallidotomy for antipsychotic drug induced tardive dyskinesia

Tardive dyskinesia (TD) is a well known side effect of neuroleptic drug treatment, and may coexist with tardive dystonia. It can be treated with several drugs, although they rarely lead to a complete removal of symptoms. The main treatment of TD consists of gradual neuroleptic drug dose reduction and where possible complete withdrawal. Nevertheless, in 40% of TD cases, symptoms do not disappear within 5 years of drug withdrawal. Wang et al first described a pallidotomy as a treatment modality for TD. In severe cases of TD and dystonia, this can lead to significant amelioration of abnormal movements and pronounced improvement in function and quality of life.

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