Epidemiological modeling of bovine brucellosis in India

The study objective is to develop an epidemiological model of brucellosis transmission dynamics among cattle in India and to estimate the impact of different prevention and control strategies. The prevention and control strategies are test-and-slaughter, transmission rate reduction, and mass vaccination. We developed a mathematical model based on the susceptible-infectious-recovered epidemic model to simulate brucellosis transmission dynamics, calibrated to the endemically stable levels of bovine brucellosis prevalence of cattle in India. We analyzed the epidemiological benefit of different rates of reduced transmission and vaccination. Test-and-slaughter is an effective strategy for elimination and eradication of brucellosis, but socio-cultural constraints forbid culling of cattle in India. Reducing transmission rates lowered the endemically stable levels of brucellosis prevalence correspondingly. One-time vaccination lowered prevalence initially but increased with influx of new susceptible births. While this epidemiological model is a basic representation of brucellosis transmission dynamics in India and constrained by limitations in surveillance data, this study illustrates the comparative epidemiological impact of different bovine brucellosis prevention and control strategies.

[1]  D. Luke,et al.  Systems science methods in public health: dynamics, networks, and agents. , 2012, Annual review of public health.

[2]  G. Renukaradhya,et al.  A serological survey of bovine brucellosis in India. , 1998, Revue scientifique et technique.

[3]  H. Fineberg,et al.  Epidemic Science in Real Time , 2009, Science.

[4]  P. Nicoletti.  Brucellosis: past, present and future. , 2010, Prilozi.

[5]  C. Pipper,et al.  [''R"--project for statistical computing]. , 2008, Ugeskrift for laeger.

[6]  P. Coffin,et al.  An introduction to infectious disease modelling , 2011 .

[7]  S. Ahmed,et al.  An overview of Brucellosis. , 2011, Mymensingh medical journal : MMJ.

[8]  B. Mantur,et al.  Brucellosis in India — a review , 2008, Journal of Biosciences.

[9]  P. Daszak,et al.  Prediction and prevention of the next pandemic zoonosis , 2012, The Lancet.

[10]  S. Boyle,et al.  Brucellosis: a re-emerging zoonosis. , 2010, Veterinary microbiology.

[11]  M. Gochfeld.  Human-Animal Medicine: Clinical Approaches to Zoonoses, Toxicants, and Other Shared Health Risks , 2010 .

[12]  H. Smits,et al.  Brucellosis in India: a deceptive infectious disease. , 2005, The Indian journal of medical research.

[13]  S. Olsen,et al.  Bovine brucellosis. , 2010, The Veterinary clinics of North America. Food animal practice.

[14]  P. Nicoletti.  Vaccination against Brucella. , 1990, Advances in biotechnological processes.

[15]  G. Renukaradhya,et al.  Epidemiology, zoonotic aspects, vaccination and control/eradication of brucellosis in India. , 2002, Veterinary microbiology.

[16]  C. Saegerman,et al.  Brucellosis at the animal/ecosystem/human interface at the beginning of the 21st century. , 2011, Preventive veterinary medicine.

[17]  E. Moreno.  Retrospective and prospective perspectives on zoonotic brucellosis , 2014, Front. Microbiol..

[18]  L. Fernandez-Herlihy,et al.  Human brucellosis. , 1959, The Lahey Clinic bulletin.

[19]  H. McCallum,et al.  How should pathogen transmission be modelled? , 2001, Trends in ecology & evolution.

[20]  A. S. Agasthya,et al.  Brucellosis in high risk group individuals. , 2007, Indian journal of medical microbiology.

[21]  P. Rabinowitz,et al.  Human-Animal Medicine: Clinical Approaches to Zoonoses, Toxicants and Other Shared Health Risks , 2009 .

[22]  MICHAEL S. Williams,et al.  Estimating herd prevalence of bovine brucellosis in 46 USA states using slaughter surveillance. , 2008, Preventive veterinary medicine.

[23]  G. Pappas.  The changing Brucella ecology: novel reservoirs, new threats. , 2010, International journal of antimicrobial agents.

[24]  Emilia Vynnycky,et al.  Comprar An Introduction to Infectious Disease Modelling | Emilia Vynnycky | 9780198565765 | Oxford University Press , 2010 .

[25]  M. Keeling,et al.  Modeling Infectious Diseases in Humans and Animals , 2007 .

[26]  Richard White,et al.  An Introduction to Infectious Disease Modelling , 2010 .