Design of liposomes for enhanced local release of drugs by hyperthermia.

Liposomes can be designed to release an entrapped drug preferentially at temperatures attainable by mild local hyperthermia. In a test system in vitro, protein synthesis by Escherichia coli is inhibited and killing of the cells is enhanced by heating neomycin-containing liposomes to their phase transition temperature to maximize drug release. In the presence of serum the ratio of release at 44 degrees C to that at 37 degrees C can be made greater than 100:1, suggesting possible applications in the treatment of tumors or local infection.

[1]  J. Weinstein,et al.  Antibody-mediated targeting of liposomes. Binding to lymphocytes does not ensure incorporation of vesicle contents into the cells. , 1978, Biochimica et biophysica acta.

[2]  J. Weinstein,et al.  Interactions of liposomes with mammalian cells. , 1978, Annual review of biophysics and bioengineering.

[3]  M. Yatvin.  The influence of membrane lipid composition and procaine on hyperthermic death of cells. , 1977, International journal of radiation biology and related studies in physics, chemistry, and medicine.

[4]  J. Weinstein,et al.  Liposome--lymphocyte interaction: saturable sites for transfer and intracellular release of liposome contents. , 1977, Proceedings of the National Academy of Sciences of the United States of America.

[5]  G. Gregoriadis,et al.  Fate of a liposome-associated agent injected into normal and tumour-bearing rodents. Attempts to improve localization in tumour tissues. , 1977, Life sciences.

[6]  J. Fendler,et al.  Liposomes as drug carriers. , 1977, Life sciences.

[7]  F. Roerdink,et al.  Leakage of sucrose from phosphatidylcholine liposomes induced by interaction with serum albumin. , 1977, Biochimica et biophysica acta.

[8]  G. Hahn,et al.  Interaction of Amphotericin B and 43° Hyperthermia , 1977 .

[9]  W. A. Hagins,et al.  Liposome-cell interaction: transfer and intracellular release of a trapped fluorescent marker. , 1977, Science.

[10]  D. Tyrrell,et al.  New aspects of liposomes. , 1976, Biochimica et biophysica acta.

[11]  J M Sturtevant,et al.  Investigation of phase transitions of lipids and lipid mixtures by sensitivity differential scanning calorimetry. , 1976, Proceedings of the National Academy of Sciences of the United States of America.

[12]  G. Gregoriadis.  The Carrier Potential of Liposomes in Biology and Medicine , 1976 .

[13]  G Gregoriadis,et al.  The carrier potential of liposomes in biology and medicine (second of two parts). , 1976, The New England journal of medicine.

[14]  R. Juliano,et al.  Lectin-mediated attachment of glycoprotein-bearing liposomes to cells , 1976, Nature.

[15]  L. van Deenen,et al.  Effect of the gel to liquid crystalline phase transition on the osmotic behaviour of phosphatidylcholine liposomes. , 1976, Biochimica et biophysica acta.

[16]  T. E. Thompson,et al.  A calorimetric and fluorescent probe study of the gel-liquid crystalline phase transition in small, single-lamellar dipalmitoylphosphatidylcholine vesicles. , 1976, Biochemistry.

[17]  G. Weissmann,et al.  Introduction of purified hexosaminidase A into Tay-Sachs leukocytes by means of immunoglobulin-coated liposomes. , 1976, Biochemistry.

[18]  E. Korn,et al.  Interaction of phospholipid vesicles with cells. Endocytosis and fusion as alternate mechanisms for the uptake of lipid-soluble and water-soluble molecules , 1975, The Journal of cell biology.

[19]  G. Gregoriadis,et al.  Homing of liposomes to target cells. , 1975, Biochemical Society transactions.

[20]  R L Juliano,et al.  The effect of particle size and charge on the clearance rates of liposomes and liposome encapsulated drugs. , 1975, Biochemical and biophysical research communications.

[21]  G. Hahn,et al.  Thermochemotherapy: synergism between hyperthermia (42-43 degrees) and adriamycin (of bleomycin) in mammalian cell inactivation. , 1975, Proceedings of the National Academy of Sciences of the United States of America.

[22]  D. Bloomgarden,et al.  A general method for the introduction of enzymes, by means of immunoglobulin-coated liposomes, into lysosomes of deficient cells. , 1975, Proceedings of the National Academy of Sciences of the United States of America.

[23]  K. Inoue.  Permeability properties of liposomes prepared from dipalmitoyllecithin, dimyristoyllecithin, egg lecithin, rat liver lecithin and beef brain sphingomyelin. , 1974, Biochimica et biophysica acta.

[24]  K. Jacobson,et al.  Phase transitions in phospholipid vesicles. Fluorescence polarization and permeability measurements concerning the effect of temperature and cholesterol. , 1973, Biochimica et biophysica acta.

[25]  A. Verkleij,et al.  Fragility of the permeability barrier of Escherichia coli. , 1972, Biochimica et biophysica acta.

[26]  B. D. Ladbrooke,et al.  Molecular interactions in mixed lecithin systems. , 1970, Biochimica et biophysica acta.

[27]  G. Crile.  Selective Destruction of Cancers After Exposure to Heat , 1962, Annals of surgery.