论文信息 - Serological analysis of the HL--A10 complex.

Serological analysis of the HL--A10 complex.

In a Caucasian blood donor population largely of Polish and German origin, W25 and W26 were shown to be distinct antigens which comprise the entire specificity of HL--A10. These antigens were in linkage disequilibrium with W18 and W16 respectively. Multiparous women with antibody against HL--A10 (W25 -- W26) had husbands typing for either W25 or W26, but never both. Other sera against HL--A11 and W32 had extra antigen reactivity with W26 and W25 respectively. Serological analysis of 21 sera with W25 and W26 reactivity suggested that the broad HL--A10 complex comprises HL--A11--W26--W25--W32. The immunolgenicity and serological reactivity of the antigens in this complex may be explained with a concept of two paired amino acid substitutions at the antigenic determinant in the HL--A peptide chain.

T. Schindler | R. Duquesnoy

[1] M. Reichlin,et al. Amino acid substitution and the antigenicity of globular proteins. , 1975, Advances in immunology.

[2] M. Tongio,et al. A Study of Maternal‐Fetal Anti‐HL‐A Immunization , 1973, Vox sanguinis.

[3] H. Kunkel,et al. Human immunoglobulins: classes, subclasses, genetic variants, and idiotypes. , 1973, Advances in immunology.

[4] E. Curtoni,et al. Identification of two determinants included in "antigen" HL-A-10 (TO 31 and TO 40) and of a new family of cross-reacting specificities (HL-A1,11,TO 30,31,40). , 2008, Tissue antigens.

[5] J. Dausset,et al. Serological and Genetic Studies of the HL‐A System , 1971, Transfusion.

[6] R. Ceppellini. Old and New Facts and Speculations about Transplantation Antigens of Man , 1971 .

[7] J. R. Batchelor,et al. Implications of cross-reactivity in the HL-A system. , 1970, Transplantation proceedings.

[8] E. Giblett. A Critique of the Theoretical Hazard of Inter vs. Intra‐Racial Transfusion * , 1961, Transfusion.