Gene therapy to improve osteogenesis in bone lesions with severe soft tissue damage

[1]  E. Mäkelä,et al.  Percutaneous bone grafting in the treatment of the delayed union and non-union of tibial fractures. , 2002, Injury.

[2]  A. Simpson,et al.  The vascularity of atrophic non-unions. , 2002, Injury.

[3]  S. T. Yoon,et al.  Osteoinductive Molecules in Orthopaedics: Basic Science and Preclinical Studies , 2002, Clinical orthopaedics and related research.

[4]  W. Lew,et al.  Osteogenic protein‐1 induced bone formation in an infected segmental defect in the rat femur , 2002, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[5]  A. Simpson,et al.  Growth factor expression during the development of atrophic non-union. , 2001, Injury.

[6]  Freddie H. Fu,et al.  Effect of Bone Morphogenetic Protein-2-Expressing Muscle-Derived Cells on Healing of Critical-Sized Bone Defects in Mice , 2001, The Journal of bone and joint surgery. American volume.

[7]  V. Goldberg,et al.  BMP‐2 induction and TGF‐β1 modulation of rat periosteal cell chondrogenesis , 2001 .

[8]  S. O’Driscoll,et al.  Localization of chondrocyte precursors in periosteum. , 2001, Osteoarthritis and cartilage.

[9]  J. Lee,et al.  Osteoprogenitor cells within skeletal muscle , 2000, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[10]  Johnny Huard,et al.  Clonal Isolation of Muscle-Derived Cells Capable of Enhancing Muscle Regeneration and Bone Healing , 2000, The Journal of cell biology.

[11]  J. Lee,et al.  Ex Vivo Gene Therapy to Produce Bone Using Different Cell Types , 2000, Clinical orthopaedics and related research.

[12]  R. Rutherford,et al.  Gene therapy-directed osteogenesis: BMP-7-transduced human fibroblasts form bone in vivo. , 2000, Human gene therapy.

[13]  A. Simpson,et al.  Metabolic activity of a new atrophic nonunion model in rabbits , 2000, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[14]  J. Huard,et al.  Matching host muscle and donor myoblasts for myosin heavy chain improves myoblast transfer therapy , 2000, Gene Therapy.

[15]  A Daluiski,et al.  The effect of regional gene therapy with bone morphogenetic protein-2-producing bone-marrow cells on the repair of segmental femoral defects in rats. , 1999, The Journal of bone and joint surgery. American volume.

[16]  J. Wozney,et al.  Bone Morphogenetic Protein-2 Increases the Rate of Callus Formation after Fracture of the Rabbit Tibia , 1999, Calcified Tissue International.

[17]  S. Boden,et al.  Posterolateral Lumbar Intertransverse Process Spine Arthrodesis With Recombinant Human Bone Morphogenetic Protein 2/Hydroxyapatite‐Tricalcium Phosphate After Laminectomy in the Nonhuman Primate , 1999, Spine.

[18]  J. Fischgrund,et al.  The Use of Recombinant Human Bone Morphogenetic Protein 2 (rhBMP‐2) to Promote Spinal Fusion in a Nonhuman Primate Anterior Interbody Fusion Model , 1999, Spine.

[19]  W. Hutton,et al.  The use of coralline hydroxyapatite with bone marrow, autogenous bone graft, or osteoinductive bone protein extract for posterolateral lumbar spine fusion. , 1999, Spine.

[20]  T A Einhorn,et al.  The cell and molecular biology of fracture healing. , 1998, Clinical orthopaedics and related research.

[21]  M. Bostrom,et al.  Expression of bone morphogenetic proteins in fracture healing. , 1998, Clinical orthopaedics and related research.

[22]  Johnny Huard,et al.  Development of Approaches to Improve Cell Survival in Myoblast Transfer Therapy , 1998, The Journal of cell biology.

[23]  M. Picardi,et al.  CD34+-enriched donor lymphocyte infusions in a case of pure red cell aplasia and late graft failure after major ABO-incompatible bone marrow transplantation , 1998, Bone Marrow Transplantation.

[24]  P. ten Dijke,et al.  Distinct and overlapping patterns of localization of bone morphogenetic protein (BMP) family members and a BMP type II receptor during fracture healing in rats. , 1998, Bone.

[25]  M. Laitinen,et al.  Use of myoblasts in assaying the osteoinductivity of bone morphogenetic proteins. , 1998, Life sciences.

[26]  S. Boden,et al.  Laparoscopic anterior spinal arthrodesis with rhBMP-2 in a titanium interbody threaded cage. , 1997, Journal of spinal disorders.

[27]  A. Reddi,et al.  Bone morphogenetic proteins: an unconventional approach to isolation of first mammalian morphogens. , 1997, Cytokine & growth factor reviews.

[28]  R. Delamarter,et al.  Effective Doses of Recombinant Human Bone Morphogenetic Protein‐2 in Experimental Spinal Fusion , 1996, Spine.

[29]  M Browne,et al.  Use of Bone Morphogenetic Protein-2 in the Rabbit Ulnar Nonunion Model , 1996, Clinical orthopaedics and related research.

[30]  J. Michael Kabo,et al.  Evaluation of rhBMP‐2 With an OPLA Carrier in a Canine Posterolateral (Transverse Process) Spinal Fusion Model , 1995, Spine.

[31]  J. Peltonen,et al.  An experimental model for non-union in rats. , 1995, Injury.

[32]  S. Cook,et al.  Recombinant human bone morphogenetic protein-7 induces healing in a canine long-bone segmental defect model. , 1994, Clinical orthopaedics and related research.

[33]  A. Reddi,et al.  Initiation and promotion of bone differentiation by bone morphogenetic proteins , 1993, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[34]  N. Haas,et al.  [Incidence of pseudarthroses in open fractures: analysis of 948 open fractures]. , 1993, Aktuelle Traumatologie.

[35]  V. Rosen,et al.  Recombinant human bone morphogenetic protein-2 stimulates osteoblastic maturation and inhibits myogenic differentiation in vitro , 1991, The Journal of cell biology.

[36]  N. Gjerdet,et al.  Effects of instability on fracture healing in the rat. , 1984, Acta orthopaedica Scandinavica.

[37]  K. Takagi,et al.  The role of bone marrow in bone morphogenetic protein-induced repair of femoral massive diaphyseal defects. , 1982, Clinical orthopaedics and related research.

[38]  M. Nathanson.  Analysis of cartilage differentiation from skeletal muscle grown on bone matrix. III. Environmental regulation of glycosaminoglycan and proteoglycan synthesis. , 1980, Developmental biology.

[39]  E. Hay,et al.  Analysis of cartilage differentiation from skeletal muscle grown on bone matrix. I. Ultrastructural aspects. , 1980, Developmental biology.

[40]  M. Urist,et al.  Bone: Formation by Autoinduction , 1965, Science.

[41]  A. Ham.  A HISTOLOGICAL STUDY OF THE EARLY PHASES OF BONE REPAIR , 1930 .

[42]  J. Huard,et al.  Human skeletal muscle cells in ex vivo gene therapy to deliver bone morphogenetic protein-2. , 2002, The Journal of bone and joint surgery. British volume.

[43]  N. Takahashi,et al.  Bone Morphogenetic Protein-2 Converts the Differentiation Pathway of C2C12 Myoblasts into the Osteoblast Lineage , 2002 .

[44]  V. Goldberg,et al.  BMP-2 induction and TGF-beta 1 modulation of rat periosteal cell chondrogenesis. , 2001, Journal of cellular biochemistry.

[45]  M. Tsunoda,et al.  Role of fracture hematoma and periosteum during fracture healing in rats: interaction of fracture hematoma and the periosteum in the initial step of the healing process , 2000, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association.

[46]  A. Reddi,et al.  Complete regeneration of bone in the baboon by recombinant human osteogenic protein-1 (hOP-1, bone morphogenetic protein-7). , 1996, Growth factors.

[47]  V. Goldberg,et al.  Bone and cartilage formation in diffusion chambers by subcultured cells derived from the periosteum. , 1990, Bone.