Epicutaneous Allergic Sensitization by Cooperation between Allergen Protease Activity and Mechanical Skin Barrier Damage in Mice.

[1]  Yusuke Suzuki,et al.  Innate basophil IL-4 responses against allergens, endotoxin, and cytokines require the Fc receptor γ-chain. , 2016, The Journal of allergy and clinical immunology.

[2]  W. Thomas.  Hierarchy and molecular properties of house dust mite allergens. , 2015, Allergology international : official journal of the Japanese Society of Allergology.

[3]  A. Heratizadeh,et al.  Der p1 and Der p2-Specific T Cells Display a Th2, Th17, and Th2/Th17 Phenotype in Atopic Dermatitis. , 2015, The Journal of investigative dermatology.

[4]  M. Mildner,et al.  Papain Degrades Tight Junction Proteins of Human Keratinocytes In Vitro and Sensitizes C57BL/6 Mice via the Skin Independent of its Enzymatic Activity or TLR4 Activation. , 2015, The Journal of investigative dermatology.

[5]  Y. Okamoto,et al.  The interleukin-33-p38 kinase axis confers memory T helper 2 cell pathogenicity in the airway. , 2015, Immunity.

[6]  Zhihui Xie,et al.  A fungal protease allergen provokes airway hyperresponsiveness in asthma , 2015, Nature Communications.

[7]  J. Girard,et al.  IL-33: an alarmin cytokine with crucial roles in innate immunity, inflammation and allergy. , 2014, Current opinion in immunology.

[8]  S. Ziegler,et al.  The role of basophils and proallergic cytokines, TSLP and IL-33, in cutaneously sensitized food allergy. , 2014, International immunology.

[9]  E. Choi,et al.  Topical acidic cream prevents the development of atopic dermatitis‐ and asthma‐like lesions in murine model , 2014, Experimental dermatology.

[10]  D. Leung,et al.  Deciphering the complexities of atopic dermatitis: shifting paradigms in treatment approaches. , 2014, The Journal of allergy and clinical immunology.

[11]  M. Gold,et al.  Group 2 Innate Lymphoid Cells Are Critical for the Initiation of Adaptive T Helper 2 Cell-Mediated Allergic Lung Inflammation , 2014, Immunity.

[12]  A. Lowe,et al.  Atopic dermatitis and the atopic march revisited , 2014, Allergy.

[13]  G. Ogg,et al.  A role for IL-25 and IL-33–driven type-2 innate lymphoid cells in atopic dermatitis , 2013, The Journal of experimental medicine.

[14]  H. Wolff,et al.  ST2 regulates allergic airway inflammation and T-cell polarization in epicutaneously sensitized mice. , 2013, The Journal of investigative dermatology.

[15]  K. Nakanishi,et al.  Skin-specific expression of IL-33 activates group 2 innate lymphoid cells and elicits atopic dermatitis-like inflammation in mice , 2013, Proceedings of the National Academy of Sciences.

[16]  S. Nakae,et al.  IL-33–Mediated Innate Response and Adaptive Immune Cells Contribute to Maximum Responses of Protease Allergen–Induced Allergic Airway Inflammation , 2013, The Journal of Immunology.

[17]  Seung Hun Lee,et al.  Protease activity enhances production of thymic stromal lymphopoietin and basophil accumulation in flaky tail mice. , 2013, The American journal of pathology.

[18]  K. Horiuchi,et al.  Stress-induced production of chemokines by hair follicles regulates the trafficking of dendritic cells in skin , 2012, Nature Immunology.

[19]  T. Reunala,et al.  IL-33 and ST2 in atopic dermatitis: expression profiles and modulation by triggering factors. , 2012, The Journal of investigative dermatology.

[20]  W. Thomas,et al.  Sensitizing and Th2 Adjuvant Activity of Cysteine Protease Allergens , 2012, International Archives of Allergy and Immunology.

[21]  S. Ziegler,et al.  Langerhans cells are critical in epicutaneous sensitization with protein antigen via thymic stromal lymphopoietin receptor signaling. , 2012, The Journal of allergy and clinical immunology.

[22]  Fumio Takei,et al.  Lung natural helper cells are a critical source of Th2 cell-type cytokines in protease allergen-induced airway inflammation. , 2012, Immunity.

[23]  L. Beck,et al.  Skin Barrier Disruption - A Requirement for Allergen Sensitization? , 2011, The Journal of investigative dermatology.

[24]  S. Ziegler,et al.  Mechanical injury polarizes skin dendritic cells to elicit a T(H)2 response by inducing cutaneous thymic stromal lymphopoietin expression. , 2010, The Journal of allergy and clinical immunology.

[25]  T. Abe,et al.  IL-33 is a crucial amplifier of innate rather than acquired immunity , 2010, Proceedings of the National Academy of Sciences.

[26]  T. Kepler,et al.  The T helper type 2 response to cysteine proteases requires dendritic cell–basophil cooperation via ROS-mediated signaling , 2010, Nature Immunology.

[27]  H. Gunawan,et al.  Staphylococcus aureus extracellular protease causes epidermal barrier dysfunction. , 2010, The Journal of investigative dermatology.

[28]  M. Amagai,et al.  External antigen uptake by Langerhans cells with reorganization of epidermal tight junction barriers , 2009, The Journal of experimental medicine.

[29]  K. Kabashima,et al.  Induction of eosinophil‐ and Th2‐attracting epidermal chemokines and cutaneous late‐phase reaction in tape‐stripped skin , 2009, Experimental dermatology.

[30]  R. Geha,et al.  Filaggrin-deficient mice exhibit TH17-dominated skin inflammation and permissiveness to epicutaneous sensitization with protein antigen. , 2009, The Journal of allergy and clinical immunology.

[31]  H. Ogawa,et al.  Mite serine protease activates protease‐activated receptor‐2 and induces cytokine release in human keratinocytes , 2009, Allergy.

[32]  H. Kita,et al.  Proteases Induce Production of Thymic Stromal Lymphopoietin by Airway Epithelial Cells through Protease-Activated Receptor-21 , 2009, The Journal of Immunology.

[33]  A. Ghaemmaghami,et al.  The molecular basis of allergenicity. , 2008, Trends in immunology.

[34]  Seung Hun Lee,et al.  Mite and cockroach allergens activate protease-activated receptor 2 and delay epidermal permeability barrier recovery. , 2008, The Journal of investigative dermatology.

[35]  G. Lack.  Epidemiologic risks for food allergy. , 2008, The Journal of allergy and clinical immunology.

[36]  H. Hammad,et al.  Dendritic cells and epithelial cells: linking innate and adaptive immunity in asthma , 2008, Nature Reviews Immunology.

[37]  Ruslan Medzhitov,et al.  A mechanism for the initiation of allergen-induced T helper type 2 responses , 2008, Nature Immunology.

[38]  F. Niyonsaba,et al.  Upregulation of the Release of Granulocyte-Macrophage Colony-Stimulating Factor from Keratinocytes Stimulated with Cysteine Protease Activity of Recombinant Major Mite Allergens, Der f 1 and Der p 1 , 2007, International Archives of Allergy and Immunology.

[39]  S. Runswick,et al.  Pollen proteolytic enzymes degrade tight junctions , 2007, Respirology.

[40]  R. Geha,et al.  Epicutaneous antigen exposure induces a Th17 response that drives airway inflammation after inhalation challenge , 2007, Proceedings of the National Academy of Sciences.

[41]  Toshinobu Nakamura,et al.  Reduction of skin barrier function by proteolytic activity of a recombinant house dust mite major allergen Der f 1. , 2006, The Journal of investigative dermatology.

[42]  H. Hatanaka,et al.  Crucial Commitment of Proteolytic Activity of a Purified Recombinant Major House Dust Mite Allergen Der p1 to Sensitization toward IgE and IgG Responses1 , 2006, The Journal of Immunology.

[43]  Colin N A Palmer,et al.  Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis , 2006, Nature Genetics.

[44]  M. Hollenberg,et al.  The House Dust Mite Allergen Der p 1, Unlike Der p 3, Stimulates the Expression of Interleukin-8 in Human Airway Epithelial Cells via a Proteinase-activated Receptor-2-independent Mechanism* , 2006, Journal of Biological Chemistry.

[45]  S. Tominaga,et al.  Functional SNPs in the distal promoter of the ST2 gene are associated with atopic dermatitis. , 2005, Human molecular genetics.

[46]  K. Mitsuishi,et al.  Cystatin A inhibits IL-8 production by keratinocytes stimulated with Der p 1 and Der f 1: biochemical skin barrier against mite cysteine proteases. , 2005, The Journal of allergy and clinical immunology.

[47]  M. Grunstein,et al.  Proasthmatic effects and mechanisms of action of the dust mite allergen, Der p 1, in airway smooth muscle. , 2005, The Journal of allergy and clinical immunology.

[48]  Hiroyuki Tanaka,et al.  Establishment of allergic dermatitis in NC/Nga mice as a model for severe atopic dermatitis. , 2004, Biological & pharmaceutical bulletin.

[49]  A. Paller,et al.  Atopic dermatitis and the atopic march. , 2003, The Journal of allergy and clinical immunology.

[50]  D. Pritchard,et al.  Basophils express a type 2 cytokine profile on exposure to proteases from helminths and house dust mites , 2003, Journal of leukocyte biology.

[51]  N. Rawlings,et al.  Evolutionary Lines of Cysteine Peptidases , 2001, Biological chemistry.

[52]  C. Soeller,et al.  The transmembrane protein occludin of epithelial tight junctions is a functional target for serine peptidases from faecal pellets of Dermatophagoides pteronyssinus , 2001, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[53]  H. Sewell,et al.  The Cysteine Protease Activity of the Major Dust Mite Allergen Der P 1 Selectively Enhances the Immunoglobulin E Antibody Response , 1999, The Journal of experimental medicine.

[54]  P. Thompson,et al.  Der p 1 facilitates transepithelial allergen delivery by disruption of tight junctions. , 1999, The Journal of clinical investigation.

[55]  D. Pritchard,et al.  Enzymatically active papain preferentially induces an allergic response in mice. , 1998, Biochemical and biophysical research communications.

[56]  G. Stewart,et al.  Dust mite proteolytic allergens induce cytokine release from cultured airway epithelium. , 1998, Journal of immunology.

[57]  R. Geha,et al.  Epicutaneous sensitization with protein antigen induces localized allergic dermatitis and hyperresponsiveness to methacholine after single exposure to aerosolized antigen in mice. , 1998, The Journal of clinical investigation.

[58]  U. Wahn,et al.  Allergen specificity of skin-infiltrating T cells is not restricted to a type-2 cytokine pattern in chronic skin lesions of atopic dermatitis. , 1996, The Journal of investigative dermatology.

[59]  Li-Fang Wang,et al.  Epicutaneous exposure of protein antigen induces a predominant Th2-like response with high IgE production in mice. , 1996, Journal of immunology.

[60]  K. Okumura,et al.  Epicutaneous administration of papain induces IgE and IgG responses in a cysteine protease activity-dependent manner. , 2014, Allergology international : official journal of the Japanese Society of Allergology.

[61]  T. Takai,et al.  Barrier dysfunction caused by environmental proteases in the pathogenesis of allergic diseases. , 2011, Allergology international : official journal of the Japanese Society of Allergology.