Phosphorylation of SOS1 on tyrosine 1196 promotes its RAC GEF activity and contributes to BCR-ABL leukemogenesis
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S. Minucci | G. Pruneri | J. Rappsilber | E. Santos | G. Scita | E. Frittoli | A. Palamidessi | E. Santos | Y. Rolland | A. Illert | S. Kreutmair | I. Pallavicini | F. Troglio | Chiara Giuliani | M. Zobel | M. Cinquanta | M. Salek | C. Giuliani | S. Gerboth | C. Gómez | F. Baltanás | J. Rappsilber | Flavia Troglio | F. Baltanas
[1] M. Freeman,et al. DRK/DOS/SOS converge with Crk/Mbc/dCed-12 to activate Rac1 during glial engulfment of axonal debris , 2014, Proceedings of the National Academy of Sciences.
[2] X. Bustelo. Vav family exchange factors: an integrated regulatory and functional view , 2014, Small GTPases.
[3] M. Pérez‐Andrés,et al. Functional Redundancy of Sos1 and Sos2 for Lymphopoiesis and Organismal Homeostasis and Survival , 2013, Molecular and Cellular Biology.
[4] C. Koh,et al. Functions and Regulation of Circular Dorsal Ruffles , 2012, Molecular and Cellular Biology.
[5] David A. Williams,et al. Vav3 collaborates with p190-BCR-ABL in lymphoid progenitor leukemogenesis, proliferation, and survival. , 2012, Blood.
[6] Ssang-Goo Cho,et al. CIIA functions as a molecular switch for the Rac1-specific GEF activity of SOS1 , 2011, The Journal of cell biology.
[7] Paramjit S. Arora,et al. An Orthosteric Inhibitor of the Ras-Sos Interaction , 2011, Nature chemical biology.
[8] A. Ridley. Life at the Leading Edge , 2011, Cell.
[9] David A. Williams,et al. Rac GTPases in Human Diseases , 2010, Disease markers.
[10] David A. Williams,et al. Rac2 GTPase deficiency depletes BCR-ABL+ leukemic stem cells and progenitors in vivo. , 2010, Blood.
[11] D. Bar-Sagi,et al. Allosteric gating of Son of sevenless activity by the histone domain , 2010, Proceedings of the National Academy of Sciences.
[12] T. Kortemme,et al. Differences in flexibility underlie functional differences in the Ras activators son of sevenless and Ras guanine nucleotide releasing factor 1. , 2009, Structure.
[13] David A. Williams,et al. Rac GTPases as key regulators of p210-BCR-ABL-dependent leukemogenesis , 2008, Leukemia.
[14] Jodi Gureasko,et al. Membrane-dependent signal integration by the Ras activator Son of sevenless , 2008, Nature Structural &Molecular Biology.
[15] Abdallah El Ali,et al. Differential motility of p190bcr-abl- and p210bcr-abl-expressing cells: respective roles of Vav and Bcr-Abl GEFs , 2008, Oncogene.
[16] David A. Williams,et al. Rac guanosine triphosphatases represent integrating molecular therapeutic targets for BCR-ABL-induced myeloproliferative disease. , 2007, Cancer cell.
[17] D. Bar-Sagi,et al. Phospholipase D2-generated phosphatidic acid couples EGFR stimulation to Ras activation by Sos , 2007, Nature Cell Biology.
[18] G. Bashaw,et al. Son of Sevenless Directly Links the Robo Receptor to Rac Activation to Control Axon Repulsion at the Midline , 2006, Neuron.
[19] A. Naqvi,et al. Sos-mediated activation of rac1 by p66shc , 2006, The Journal of cell biology.
[20] P. Roepstorff,et al. Highly Selective Enrichment of Phosphorylated Peptides from Peptide Mixtures Using Titanium Dioxide Microcolumns* , 2005, Molecular & Cellular Proteomics.
[21] V. Kaartinen,et al. Generation of rac3 Null Mutant Mice: Role of Rac3 in Bcr/Abl-Caused Lymphoblastic Leukemia , 2005, Molecular and Cellular Biology.
[22] Holger Sondermann,et al. Structural Analysis of Autoinhibition in the Ras Activator Son of Sevenless , 2004, Cell.
[23] A. Heck,et al. Selective isolation at the femtomole level of phosphopeptides from proteolytic digests using 2D-NanoLC-ESI-MS/MS and titanium oxide precolumns. , 2004, Analytical chemistry.
[24] A. Koleske,et al. Bidirectional Signaling Links the Abelson Kinases to the Platelet-Derived Growth Factor Receptor , 2004, Molecular and Cellular Biology.
[25] A. Koleske,et al. Abl-dependent tyrosine phosphorylation of Sos-1 mediates growth-factor-induced Rac activation , 2004, Nature Cell Biology.
[26] Holger Sondermann,et al. Tandem histone folds in the structure of the N-terminal segment of the ras activator Son of Sevenless. , 2003, Structure.
[27] W. Lehmann,et al. Analysis of protein tyrosine phosphorylation by nanoelectrospray ionization high-resolution tandem mass spectrometry and tyrosine-targeted product ion scanning. , 2003, Analytical chemistry.
[28] Andre Hoelz,et al. Structural Evidence for Feedback Activation by Ras·GTP of the Ras-Specific Nucleotide Exchange Factor SOS , 2003, Cell.
[29] G. Scita,et al. Phosphoinositide 3-kinase activates Rac by entering in a complex with Eps8, Abi1, and Sos-1 , 2003, The Journal of cell biology.
[30] J. Downing,et al. Bethesda proposals for classification of nonlymphoid hematopoietic neoplasms in mice. , 2002, Blood.
[31] F. Bassermann,et al. Association of Bcr-Abl with the Proto-oncogene Vav Is Implicated in Activation of the Rac-1 Pathway* , 2002, The Journal of Biological Chemistry.
[32] Giorgio Scita,et al. Mechanisms through which Sos-1 coordinates the activation of Ras and Rac , 2002, The Journal of cell biology.
[33] G. Scita,et al. An effector region in Eps8 is responsible for the activation of the Rac-specific GEF activity of Sos-1 and for the proper localization of the Rac-based actin–polymerizing machine , 2001, The Journal of cell biology.
[34] H. Steen,et al. Quadrupole time-of-flight versus triple-quadrupole mass spectrometry for the determination of phosphopeptides by precursor ion scanning. , 2001, Journal of mass spectrometry : JMS.
[35] B. Druker,et al. STI571: targeting BCR-ABL as therapy for CML. , 2001, The oncologist.
[36] D Broek,et al. Control of Intramolecular Interactions between the Pleckstrin Homology and Dbl Homology Domains of Vav and Sos1 Regulates Rac Binding* , 2000, The Journal of Biological Chemistry.
[37] Jian Zhang,et al. ZAP-70 Is Essential for the T Cell Antigen Receptor-induced Plasma Membrane Targeting of SOS and Vav in T Cells* , 2000, The Journal of Biological Chemistry.
[38] C. Betsholtz,et al. EPS8 and E3B1 transduce signals from Ras to Rac , 1999, Nature.
[39] A. Kazlauskas,et al. c-Abl is activated by growth factors and Src family kinases and has a role in the cellular response to PDGF. , 1999, Genes & development.
[40] Sun-Hee Kim,et al. Role of Ras/ERK-dependent pathway in the erythroid differentiation of K562 cells , 1999, Experimental & Molecular Medicine.
[41] D. Bar-Sagi,et al. Crystal Structure of the Dbl and Pleckstrin Homology Domains from the Human Son of Sevenless Protein , 1998, Cell.
[42] P Salomoni,et al. BCR/ABL-mediated leukemogenesis requires the activity of the small GTP-binding protein Rac. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[43] Y. Hayashi,et al. ABI-1, a human homolog to mouse Abl-interactor 1, fuses the MLL gene in acute myeloid leukemia with t(10;11)(p11.2;q23). , 1998, Blood.
[44] Hong Gu,et al. Identification of a Candidate Human Spectrin Src Homology 3 Domain-binding Protein Suggests a General Mechanism of Association of Tyrosine Kinases with the Spectrin-based Membrane Skeleton* , 1998, The Journal of Biological Chemistry.
[45] D. Bar-Sagi,et al. Coupling of Ras and Rac guanosine triphosphatases through the Ras exchanger Sos. , 1998, Science.
[46] Julian Downward,et al. Epidermal growth factor regulates p21 ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor , 1993, Cell.
[47] F. McCormick,et al. Evidence for regulation of the human ABL tyrosine kinase by a cellular inhibitor. , 1991, Proceedings of the National Academy of Sciences of the United States of America.
[48] G. Daley,et al. The CML-specific P210 bcr/abl protein, unlike v-abl, does not transform NIH/3T3 fibroblasts. , 1987, Science.
[49] David A. Williams,et al. Rho GTPases and regulation of hematopoietic stem cell localization. , 2008, Methods in enzymology.
[50] C. Der,et al. Structural basis for the selective activation of Rho GTPases by Dbl exchange factors , 2002, Nature Structural Biology.