γδ T cell effector functions: a blend of innate programming and acquired plasticity
暂无分享,去创建一个
[1] D. Kasper,et al. Microbial colonization drives expansion of IL-1 receptor 1-expressing and IL-17-producing gamma/delta T cells. , 2010, Cell host & microbe.
[2] W. Leonard,et al. Cutting Edge: Spontaneous Development of IL-17–Producing γδ T Cells in the Thymus Occurs via a TGF-β1–Dependent Mechanism , 2010, The Journal of Immunology.
[3] E. Kremmer,et al. CCR6 and NK1.1 distinguish between IL‐17A and IFN‐γ‐producing γδ effector T cells , 2009, European journal of immunology.
[4] C. King,et al. New insights into the differentiation and function of T follicular helper cells , 2009, Nature Reviews Immunology.
[5] Wutian Wu,et al. Human γδ T Cells: A Lymphoid Lineage Cell Capable of Professional Phagocytosis1 , 2009, The Journal of Immunology.
[6] M. Bonneville,et al. Early Triggering of Exclusive IFN-γ Responses of Human Vγ9Vδ2 T Cells by TLR-Activated Myeloid and Plasmacytoid Dendritic Cells1 , 2009, The Journal of Immunology.
[7] C. Agrati,et al. Cutting Edge: TGF-β1 and IL-15 Induce FOXP3+ γδ Regulatory T Cells in the Presence of Antigen Stimulation1 , 2009, The Journal of Immunology.
[8] J. Peiris,et al. Phosphoantigen-Expanded Human γδ T Cells Display Potent Cytotoxicity against Monocyte-Derived Macrophages Infected with Human and Avian Influenza Viruses , 2009, The Journal of infectious diseases.
[9] A. Hayday. Gammadelta T cells and the lymphoid stress-surveillance response. , 2009, Immunity.
[10] D. Raulet,et al. Oncogenic stress sensed by the immune system: role of natural killer cell receptors , 2009, Nature Reviews Immunology.
[11] K. Ohmura,et al. Gamma/delta T cells are the predominant source of interleukin-17 in affected joints in collagen-induced arthritis, but not in rheumatoid arthritis. , 2009, Arthritis and rheumatism.
[12] T. Iwaki,et al. Pivotal role of cerebral interleukin-17–producing γδT cells in the delayed phase of ischemic brain injury , 2009, Nature Medicine.
[13] P. Pandolfi,et al. TCR-inducible PLZF transcription factor required for innate phenotype of a subset of γδ T cells with restricted TCR diversity , 2009, Proceedings of the National Academy of Sciences.
[14] Hua Huang,et al. The Influence of IgE-Enhancing and IgE-Suppressive γδ T Cells Changes with Exposure to Inhaled Ovalbumin1 , 2009, The Journal of Immunology.
[15] H. Kaplan,et al. Major Role of γδ T Cells in the Generation of IL-17+ Uveitogenic T Cells1 , 2009, The Journal of Immunology.
[16] A. Poggi,et al. Vdelta1 T lymphocytes producing IFN-gamma and IL-17 are expanded in HIV-1-infected patients and respond to Candida albicans. , 2009, Blood.
[17] Joonsoo Kang,et al. Tec kinase Itk in γδT cells is pivotal for controlling IgE production in vivo , 2009, Proceedings of the National Academy of Sciences.
[18] W. Born,et al. IL-17A-Expressing T Cells Are Essential for Bacterial Clearance in a Murine Model of Hypersensitivity Pneumonitis1 , 2009, The Journal of Immunology.
[19] G. Laurent,et al. Bromohydrin pyrophosphate enhances antibody-dependent cell-mediated cytotoxicity induced by therapeutic antibodies. , 2009, Blood.
[20] H. Jomaa,et al. Antigen-specific Vγ2Vδ2 T effector cells confer homeostatic protection against pneumonic plaque lesions , 2009, Proceedings of the National Academy of Sciences.
[21] E. Gelfand,et al. Vgamma1+ T cells and tumor necrosis factor-alpha in ozone-induced airway hyperresponsiveness. , 2009, American journal of respiratory cell and molecular biology.
[22] M. Bonneville,et al. IL-21-Mediated Potentiation of Antitumor Cytolytic and Proinflammatory Responses of Human Vγ9Vδ2 T Cells for Adoptive Immunotherapy1 , 2009, The Journal of Immunology.
[23] A. Hayday,et al. CD27 is a thymic determinant of the balance between interferon-γ- and interleukin 17–producing γδ T cell subsets , 2009, Nature Immunology.
[24] R. Tampé,et al. Cross-presenting human γδ T cells induce robust CD8+ αβ T cell responses , 2009, Proceedings of the National Academy of Sciences.
[25] M. Eberl,et al. A Rapid Crosstalk of Human γδ T Cells and Monocytes Drives the Acute Inflammation in Bacterial Infections , 2009, PLoS pathogens.
[26] A. Hayday,et al. Pulmonary Vγ4+ γδ T Cells Have Proinflammatory and Antiviral Effects in Viral Lung Disease1 , 2009, The Journal of Immunology.
[27] W. Born,et al. Vγ1+ γδ T cells reduce IL-10-producing CD4+CD25+ T cells in the lung of ovalbumin-sensitized and challenged mice. , 2008, Immunology letters.
[28] J. Rossi,et al. A Phase I/II Study of IPH1101 (BrHPP), Specific Agonist of V gamma 9V delta 2 T Lymphocytes, in Combination with Rituximab Re-Treatment in Patients with Follicular Lymphoma. Interim Phase I Data. , 2008 .
[29] H. Kaplan,et al. Mouse γδ T cells are capable of expressing MHC class II molecules, and of functioning as antigen-presenting cells , 2008, Journal of Neuroimmunology.
[30] P. Pandolfi,et al. The BTB–zinc finger transcriptional regulator PLZF controls the development of invariant natural killer T cell effector functions , 2008, Nature Immunology.
[31] Mark M. Davis,et al. Thymic selection determines gammadelta T cell effector fate: antigen-naive cells make interleukin-17 and antigen-experienced cells make interferon gamma. , 2008, Immunity.
[32] Sunny Shin,et al. An autonomous CDR3δ is sufficient for recognition of the nonclassical MHC class I molecules T10 and T22 by γδ T cells , 2008, Nature Immunology.
[33] E. Gelfand,et al. Evidence That CD8+ Dendritic Cells Enable the Development of γδ T Cells That Modulate Airway Hyperresponsiveness1 , 2008, The Journal of Immunology.
[34] R. Medzhitov. Origin and physiological roles of inflammation , 2008, Nature.
[35] Jing Wang,et al. Interleukin 17-Producing γδ T Cells Increased in Patients with Active Pulmonary Tuberculosis , 2008, Cellular and Molecular Immunology.
[36] Chen Dong,et al. TH17 cells in development: an updated view of their molecular identity and genetic programming , 2008, Nature Reviews Immunology.
[37] Julia M. Lewis,et al. Skint1, the prototype of a newly identified immunoglobulin superfamily gene cluster, positively selects epidermal γδ T cells , 2008, Nature Genetics.
[38] M. A. Basson,et al. Itch-/- alphabeta and gammadelta T cells independently contribute to autoimmunity in Itchy mice. , 2008, Blood.
[39] R. Braun,et al. IL-17 Producing γδ T Cells are Required for a Controlled Inflammatory Response after Bleomycin-induced Lung Injury , 2008, Inflammation.
[40] Julia M. Lewis,et al. Acute upregulation of an NKG2D ligand promotes rapid reorganization of a local immune compartment with pleiotropic effects on carcinogenesis , 2008, Nature Immunology.
[41] U. Grohmann,et al. Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease , 2008, Nature.
[42] G. Bhagat,et al. Small intestinal CD8 + TCRγδ + NKG2A + intraepithelial lymphocytes have attributes of regulatory cells in patients with celiac disease , 2008 .
[43] A. Bendele,et al. Exacerbation of Collagen-Induced Arthritis by Oligoclonal, IL-17-Producing γδ T Cells1 , 2007, The Journal of Immunology.
[44] C. Smith,et al. gamma delta T cells are necessary for platelet and neutrophil accumulation in limbal vessels and efficient epithelial repair after corneal abrasion. , 2007, The American journal of pathology.
[45] E. Gelfand,et al. Airway Hyperresponsiveness through Synergy of γδ T Cells and NKT Cells1 , 2007, The Journal of Immunology.
[46] Helen Y Wang,et al. Tumor-Infiltrating γδ T Cells Suppress T and Dendritic Cell Function via Mechanisms Controlled by a Unique Toll-like Receptor Signaling Pathway , 2007 .
[47] M. Eberl,et al. Targeting human {gamma}delta} T cells with zoledronate and interleukin-2 for immunotherapy of hormone-refractory prostate cancer. , 2007, Cancer research.
[48] H. Chi,et al. Epigenetic and transcriptional programs lead to default IFN-γ production by γδ T cells , 2007, The Journal of Immunology.
[49] M. Tenenhaus,et al. A role for human skin–resident T cells in wound healing , 2007, The Journal of experimental medicine.
[50] D. Harris,et al. Depletion of γδ T Cells Exacerbates Murine Adriamycin Nephropathy , 2007 .
[51] C. Langford,et al. Distinct Cytokine-Driven Responses of Activated Blood γδ T Cells: Insights into Unconventional T Cell Pleiotropy1 , 2007, The Journal of Immunology.
[52] W. Born,et al. γδ T‐cell receptors: functional correlations , 2007 .
[53] J. Jameson,et al. Skin γδ T‐cell functions in homeostasis and wound healing , 2007 .
[54] M. Bonneville,et al. Self/non‐self discrimination by human γδ T cells: simple solutions for a complex issue? , 2007 .
[55] J. Niederkorn,et al. γδ T Cells Promote Anterior Chamber-Associated Immune Deviation and Immune Privilege through Their Production of IL-101 , 2006, The Journal of Immunology.
[56] V. Lafont,et al. Release of LL-37 by Activated Human Vγ9Vδ2 T Cells: A Microbicidal Weapon against Brucella suis1 , 2006, The Journal of Immunology.
[57] M. Bonneville,et al. Human Vγ9Vδ2 T cells : promising new leads for immunotherapy of infections and tumors , 2006 .
[58] Julia M. Lewis,et al. Selection of the cutaneous intraepithelial γδ+ T cell repertoire by a thymic stromal determinant , 2006, Nature Immunology.
[59] M. Bonneville,et al. Potentiation of Antigen-Stimulated Vγ9Vδ2 T Cell Cytokine Production by Immature Dendritic Cells (DC) and Reciprocal Effect on DC Maturation1 , 2006, The Journal of Immunology.
[60] M. Bonneville,et al. In Vivo Immunomanipulation of Vγ9Vδ2 T Cells with a Synthetic Phosphoantigen in a Preclinical Nonhuman Primate Model , 2005, The Journal of Immunology.
[61] M. Bonneville,et al. Vγ9Vδ2 T Cell Response to Colon Carcinoma Cells1 , 2005, The Journal of Immunology.
[62] D. Kabelitz,et al. Activation of Vγ9Vδ2 T Cells by NKG2D1 , 2005, The Journal of Immunology.
[63] B. Moser,et al. Professional Antigen-Presentation Function by Human γδ T Cells , 2005, Science.
[64] A. Sawaguchi,et al. Intraepithelial lymphocytes express junctional molecules in murine small intestine. , 2005, Biochemical and biophysical research communications.
[65] H. de la Salle,et al. Shared reactivity of Vδ2neg γδ T cells against cytomegalovirus-infected cells and tumor intestinal epithelial cells , 2005, The Journal of experimental medicine.
[66] J. Jameson,et al. γδ T cell–induced hyaluronan production by epithelial cells regulates inflammation , 2005, The Journal of experimental medicine.
[67] K. Christopher Garcia,et al. Structure of a γδ T Cell Receptor in Complex with the Nonclassical MHC T22 , 2005, Science.
[68] K. Ley,et al. Phagocytosis of apoptotic neutrophils regulates granulopoiesis via IL-23 and IL-17. , 2005, Immunity.
[69] E. Gelfand,et al. Mismatched Antigen Prepares γδ T Cells for Suppression of Airway Hyperresponsiveness1 , 2005, The Journal of Immunology.
[70] S. Chouaib,et al. Phosphostim-Activated γδ T Cells Kill Autologous Metastatic Renal Cell Carcinoma1 , 2005, The Journal of Immunology.
[71] F. Poccia,et al. Reciprocal Activating Interaction Between Dendritic Cells and Pamidronate-Stimulated γδ T Cells: Role of CD86 and Inflammatory Cytokines1 , 2005, The Journal of Immunology.
[72] D. Raulet. Interplay of natural killer cells and their receptors with the adaptive immune response , 2004, Nature Immunology.
[73] Jane E. Dalton,et al. Fas-Fas Ligand Interactions Are Essential for the Binding to and Killing of Activated Macrophages by γδ T Cells , 2004, The Journal of Immunology.
[74] A. Yoshimura,et al. Mucosal T Cells Bearing TCRγδ Play a Protective Role in Intestinal Inflammation1 , 2004, The Journal of Immunology.
[75] D. Raulet,et al. Positive Selection of Dendritic Epidermal γδ T Cell Precursors in the Fetal Thymus Determines Expression of Skin-Homing Receptors , 2004 .
[76] Hua Yang,et al. Intestinal Intraepithelial Lymphocyte γδ-T Cell-Derived Keratinocyte Growth Factor Modulates Epithelial Growth in the Mouse1 , 2004, The Journal of Immunology.
[77] Michael B Brenner,et al. CD1: antigen presentation and T cell function. , 2004, Annual review of immunology.
[78] J. Jameson,et al. A Keratinocyte-Responsive γδ TCR Is Necessary for Dendritic Epidermal T Cell Activation by Damaged Keratinocytes and Maintenance in the Epidermis1 , 2004, The Journal of Immunology.
[79] E. Gelfand,et al. Different Potentials of γδ T Cell Subsets in Regulating Airway Responsiveness: Vγ1+ Cells, but Not Vγ4+ Cells, Promote Airway Hyperreactivity, Th2 Cytokines, and Airway Inflammation1 , 2004, The Journal of Immunology.
[80] Hiroshi Yamamoto,et al. Role of γδT Cells in the Inflammatory Response of Experimental Colitis Mice 1 , 2003, The Journal of Immunology.
[81] B. Moser,et al. Flexible migration program regulates γδ T-cell involvement in humoral immunity , 2003 .
[82] L. Xerri,et al. LAT regulates γδ T cell homeostasis and differentiation , 2003, Nature Immunology.
[83] P. Reimer,et al. Gammadelta T cells for immune therapy of patients with lymphoid malignancies. , 2003, Blood.
[84] Olivier Lantz,et al. Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1 , 2003, Nature.
[85] E. Fuchs,et al. Protection of the intestinal mucosa by intraepithelial γδ T cells , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[86] S. Huber,et al. γδ T Cells Promote a Th1 Response during Coxsackievirus B3 Infection In Vivo: Role of Fas and Fas Ligand , 2002, Journal of Virology.
[87] E. Helm,et al. Reciprocal alterations of Th1/Th2 function in γδ T‐cell subsets of human immunodeficiency virus‐1‐infected patients , 2002, British journal of haematology.
[88] E. Gelfand,et al. MHC class I-dependent Vγ4+ pulmonary T cells regulate αβ T cell-independent airway responsiveness , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[89] J. Wiesner,et al. Identification of (E)‐4‐hydroxy‐3‐methyl‐but‐2‐enyl pyrophosphate as a major activator for human γδ T cells in Escherichia coli , 2001 .
[90] Marc Bonneville,et al. Autoreactivity by design: innate B and T lymphocytes , 2001, Nature Reviews Immunology.
[91] M. Bonneville,et al. Granulysin-Dependent Killing of Intracellular and Extracellular Mycobacterium tuberculosis by Vγ9/Vδ2 T Lymphocytes , 2001 .
[92] Julia M. Lewis,et al. Regulation of Cutaneous Malignancy by γδ T Cells , 2001, Science.
[93] D. Kabelitz,et al. Differentiation of Resting Human Peripheral Blood γδ T Cells toward Th1- or Th2-Phenotype , 2001 .
[94] M. Newell,et al. Vγ1+ T Cells Suppress and Vγ4+ T Cells Promote Susceptibility to Coxsackievirus B3-Induced Myocarditis in Mice1 , 2000, The Journal of Immunology.
[95] Stefania Gallucci,et al. Natural adjuvants: Endogenous activators of dendritic cells , 1999, Nature Medicine.
[96] P. Pereira,et al. IL-4-producing gamma delta T cells that express a very restricted TCR repertoire are preferentially localized in liver and spleen. , 1999, Journal of immunology.
[97] P. Pereira,et al. IL-4-Producing γδ T Cells That Express a Very Restricted TCR Repertoire Are Preferentially Localized in Liver and Spleen , 1999, The Journal of Immunology.
[98] M. Bonneville,et al. Implication of γδ T cells in the human immune response to cytomegalovirus , 1999 .
[99] D. Novosad,et al. Cutting Edge: Protective Response to Pulmonary Injury Requires γδ T Lymphocytes , 1999, The Journal of Immunology.
[100] P. Pereira,et al. Requirement for γδ T Cells in Allergic Airway Inflammation , 1998 .
[101] R. Steinman,et al. Dendritic cells and the control of immunity , 1998, Nature.
[102] W. Born,et al. Evidence that the same gamma delta T cells respond during infection-induced and autoimmune inflammation. , 1997, Journal of immunology.
[103] J. Tschopp,et al. Apoptosis of Fashigh CD4+ Synovial T Cells by Borrelia-reactive Fas-ligandhigh γδ T Cells in Lyme Arthritis , 1996, The Journal of experimental medicine.
[104] C. W. Lee,et al. Disease-specific changes in gammadelta T cell repertoire and function in patients with pulmonary tuberculosis. , 1996, Journal of immunology.
[105] J. Ragnaud,et al. Increases in CD3+CD4-CD8- T lymphocytes in AIDS patients with disseminated Mycobacterium avium-intracellulare complex infection. , 1996, The Journal of infectious diseases.
[106] A. West,et al. T-cell alpha beta + and gamma delta + deficient mice display abnormal but distinct phenotypes toward a natural, widespread infection of the intestinal epithelium. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[107] W. Pao,et al. γδ T cell help of B cells is induced by repeated parasitic infection, in the absence of other T cells , 1996, Current Biology.
[108] W. Pao,et al. Germinal center formation, immunoglobulin class switching, and autoantibody production driven by "non alpha/beta" T cells , 1996, The Journal of experimental medicine.
[109] S. Itohara,et al. Resistance to cutaneous graft-vs.-host disease is not induced in T cell receptor delta gene-mutant mice , 1996, The Journal of experimental medicine.
[110] S. Tonegawa,et al. Homeostatic regulation of intestinal epithelia by intraepithelial gamma delta T cells. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[111] B. Bloom,et al. Natural and synthetic non-peptide antigens recognized by human γδ T cells , 1995, Nature.
[112] P. Campbell,et al. Immune protection and control of inflammatory tissue necrosis by gamma delta T cells. , 1994, Journal of immunology.
[113] P. Holt,et al. Regulation of IgE responses to inhaled antigen in mice by antigen-specific gamma delta T cells. , 1994, Science.
[114] P. Linsley,et al. Unique antigen recognition by a herpesvirus-specific TCR-gamma delta cell. , 1994, Journal of immunology.
[115] M. Bonneville,et al. Stimulation of human gamma delta T cells by nonpeptidic mycobacterial ligands. , 1994, Science.
[116] S. Tonegawa,et al. Different roles of αβ and γδ T cells in immunity against an intracellular bacterial pathogen , 1993, Nature.
[117] S. Carding,et al. Characterization of gamma delta T lymphocytes at the maternal-fetal interface. , 1992, Journal of immunology.
[118] C. Martínez-A,et al. Functionally distinct subsets of human γ/δ T cells , 1991 .
[119] J. D. Young,et al. Expression of perforin and serine esterases by human gamma/delta T cells , 1991, The Journal of experimental medicine.
[120] L. Lefrançois,et al. Expression of gamma/delta T cell receptors on lymphocytes from the lactating mammary gland , 1990, The Journal of experimental medicine.
[121] S. Kyes,et al. Late dominance of the inflammatory process in murine influenza by gamma/delta + T cells , 1990, The Journal of experimental medicine.
[122] M. Lefranc,et al. A nomenclature to fit the organization of the human T-cell receptor gamma and delta genes. , 1990, Research in immunology.
[123] J. Strominger,et al. Evidence for extrathymic changes in the T cell receptor gamma/delta repertoire , 1990, The Journal of experimental medicine.
[124] J. Allison,et al. Developmentally ordered appearance of thymocytes expressing different T-cell antigen receptors , 1988, Nature.
[125] A. Finnegan,et al. Antigen recognition by T cells. , 1986, Immunology today.
[126] Simone Cardoso de Oliveira,et al. Affiliations , 1942, Migration, Stability and Solidarity.
[127] L. Chun. IL-17-producing γδ T cells , 2012 .
[128] A. Poggi,et al. V 1 T lymphocytes producing IFN-and IL-17 are expanded in HIV-1 – infected patients and respond to Candida albicans , 2009 .
[129] M. A. Basson,et al. Itch (cid:1) / (cid:1) (cid:2)(cid:3) and (cid:4)(cid:5) T cells independently contribute to autoimmunity in Itchy mice , 2008 .
[130] 浜田 聡. IL-17A produced by γδ T cells plays a critical role in innate immunity against Listeria monocytogenes infection in the liver , 2008 .
[131] 柴田 健輔. Resident Vδ1[+] γδ T cells control early infiltration of neutrophils after Escherichia coli infection via IL-17 production , 2008 .
[132] W. Born,et al. Macrophages Express Multiple Ligands for γδ TCRs , 2008 .
[133] G. Trinchieri,et al. Dendritic cell-NK cell cross-talk: regulation and physiopathology. , 2006, Current topics in microbiology and immunology.
[134] M. Bonneville,et al. Human Vgamma9Vdelta2 T cells: promising new leads for immunotherapy of infections and tumors. , 2006, Current opinion in immunology.
[135] V. Lafont,et al. Release of LL-37 by activated human Vgamma9Vdelta2 T cells: a microbicidal weapon against Brucella suis. , 2006, Journal of immunology.
[136] Zou Sheng-qua. Role of Fas and Fas ligand in immune escape of gallbladder carcinoma , 2005 .
[137] Hajime,et al. Homeostatic regulation of intestinal epithelia by intraepithelial y 6 T cells , 2005 .
[138] A. Hayday,et al. T-cell aj 3 + and yS 3 deficient mice display abnormal but distinct phenotypes toward a natural , widespread infection of the intestinal epithelium , 2005 .
[139] Susan Wong,et al. Germinal Center Formation , Immunoglobulin Class Switching , and Autoantibody Production Driven by " Non 0 L / J 3 " T Cells , 2003 .
[140] D. Kabelitz,et al. Features and functions of gamma delta T lymphocytes: focus on chemokines and their receptors. , 2003, Critical reviews in immunology.
[141] Hiroshi Yamamoto,et al. Role of T Cells in the Inflammatory Response of Experimental Colitis Mice , 2003 .
[142] William,et al. Late Dominance of the Inflammatory Process in Murine Influenza by ,y/S+ T Cells , 2003 .
[143] F. Preffer,et al. Role of the CD5 molecule on TCR γδ T cell‐mediated immune functions: development of germinal centers and chronic intestinal inflammation , 2003 .
[144] C. Janeway,et al. Innate immune recognition. , 2002, Annual review of immunology.
[145] S. Tonegawa,et al. Diversity, development, ligands, and probable functions of gamma delta T cells. , 1991, Advances in experimental medicine and biology.
[146] Morita,et al. Evidence for Extrathymic Changes in the T Cell Receptor Y/b Repertoire , 1990 .
[147] D. Raulet. The structure, function, and molecular genetics of the gamma/delta T cell receptor. , 1989, Annual review of immunology.
[148] R. Coffman,et al. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. , 1989, Annual review of immunology.
[149] S. Tonegawa,et al. Diversity, Development, Ligands, and Probable Functions of γδ T Cells , 1989 .
[150] S. Tonegawa,et al. Diversity of murine gamma genes and expression in fetal and adult T lymphocytes , 1986, Nature.
[151] M. Veldhoen,et al. Interleukin-17-Producing gd T Cells Selectively Expand in Response to Pathogen Products and Environmental Signals , 2022 .