The Human Cell Atlas

The recent advent of methods for high-throughput single-cell molecular profiling has catalyzed a growing sense in the scientific community that the time is ripe to complete the 150-year-old effort to identify all cell types in the human body, by undertaking a Human Cell Atlas Project as an international collaborative effort. The aim would be to define all human cell types in terms of distinctive molecular profiles (e.g., gene expression) and connect this information with classical cellular descriptions (e.g., location and morphology). A comprehensive reference map of the molecular state of cells in healthy human tissues would propel the systematic study of physiological states, developmental trajectories, regulatory circuitry and interactions of cells, as well as provide a framework for understanding cellular dysregulation in human disease. Here we describe the idea, its potential utility, early proofs-of-concept, and some design considerations for the Human Cell Atlas.

Roland Eils | Alexander van Oudenaarden | Hans Clevers | Garry Nolan | Eric S. Lander | Sarah A. Teichmann | Berthold Göttgens | John C. Marioni | Aviv Regev | Ewan Birney | Nir Yosef | Chris P. Ponting | Ehud Shapiro | Jonathan Weissman | Nir Hacohen | Joakim Lundeberg | Fabian J Theis | Joshua Sanes | Martin Hemberg | Andrew Farmer | Fiona Watt | Ian Dunham | Piero Carninci | Jay W. Shin | Partha Majumder | Bernd Bodenmiller | Ido Amit | Rahul Satija | Oliver Stegle | Wolfgang Enard | Peter Campbell | Arnold Kriegstein | Michael Stratton | Allon Wagner | Bart Deplancke | Ed Lein | Miriam Merad | Dana Pe’er | Lars Fugger | Ton N. Schumacher | Christophe Benoist | Musa Mhlanga | Michael J. T. Stubbington | Orit Rozenblatt-Rosen | Wolf Reik | Sten Linnarsson | Barbara Wold | Martijn Nawijn | D. Pe’er | G. Nolan | E. Shapiro | S. Linnarsson | I. Amit | N. Hacohen | A. Regev | E. Birney | E. Lander | C. Ponting | S. Quake | B. Wold | S. Teichmann | R. Xavier | M. Netea | R. Eils | E. Lein | J. Sanes | M. Stratton | J. Weissman | J. Marioni | P. Campbell | I. Dunham | B. Göttgens | A. Kriegstein | A. van Oudenaarden | Piero Carninci | P. Klenerman | O. Rozenblatt-Rosen | A. Shalek | R. Satija | N. Yosef | T. Schumacher | O. Stegle | H. Clevers | E. Lundberg | J. Eberwine | W. Enard | C. Benoist | Bernd Bodenmiller | M. Clatworthy | B. Deplancke | A. Farmer | L. Fugger | M. Haniffa | M. Hemberg | Seung Kim | J. Lundeberg | P. Majumder | M. Merad | M. Mhlanga | M. Nawijn | Anthony Phillipakis | W. Reik | P. Sharma | M. Stubbington | M. Uhlén | Allon Wagner | F. Watt | Mitchell D Stratton | P. Campbell | P. Carninci | Ramnik Xavier | Padmanee Sharma | Muzlifah Haniffa | Paul Klenerman | James Eberwine | Menna Clatworthy | Alex Shalek | Mihai Netea | Seung Kim | Steve Quake | Anthony Phillipakis | D. Pe’er | James Eberwine | Ian M Dunham | Sarah A. Teichmann | M. Netea | Arnold R. Kriegstein | Fiona M. Watt | Partha P. Majumder | Seung-yun Kim | Chris P. Ponting | J. Weissman | A. Shalek | S. Quake | Eric S. Lander | Bernd Bodenmiller | Hans Clevers | Lars Fugger | Paul Klenerman | Musa Mhlanga | G. Nolan | B. Wold | C. P. Ponting

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