Expression of MUC15 and PI3K/Akt in gastric carcinoma and its association with clini- copathological characteristics and prognosis

摘要 目的:探讨MUC15和PI3K/Akt的表达与胃癌临床病理特征和预后的关系。方法:采用组织芯片和免疫组织化学法检测 144例胃癌组织及对应癌旁组织中MUC15、Akt的表达。结果:MUC15在胃癌中阳性表达率为79.8%,高于癌旁组织中的阳性表达 率22.2%(P<0.01);Akt在胃癌中阳性表达率为80.6%,高于癌旁组织的阳性表达率16.7%(P<0.01)。MUC15和Akt表达均与胃癌 分化程度、浸润深度、有无淋巴结转移和TNM分期相关(P<0.05);且胃癌组织中MUC15表达和Akt表达呈正相关(P=0.001)。单 因素生存分析显示,MUC15和Akt高表达均与生存时间呈负相关(P<0.05)。Cox多元回归分析提示,MUC15和Akt同时阳性的胃 癌患者预后更差(HR=3.115,P<0.05)。结论:MUC15可能通过 PI3K/Akt细胞信号转导通路参与胃癌的发生、发展、浸润转移, MUC15结合Akt是胃癌预后强有力的预测因子。 关键词 胃癌 免疫组织化学 MUC15 PI3K/Akt 预后 doi:10.3969/j.issn.1000-8179.2016.02.211

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