Treatment patterns for hepatocellular carcinoma in patients with Child–Pugh class B and their impact on survival: A Korean nationwide registry study

There are no established practice guidelines for treating hepatocellular carcinoma (HCC) in patients with Child–Turcotte–Pugh (CTP) class B liver function. To evaluate the impact of various initial treatment modalities on these patients, we conducted a nationwide registry study in Korea.

[1]  J. Bruix,et al.  BCLC strategy for prognosis prediction and treatment recommendation Barcelona Clinic Liver Cancer (BCLC) staging system. The 2022 update. , 2021, Journal of hepatology.

[2]  Jeong Hoon Lee,et al.  Hepatocellular Carcinoma in Korea: an Analysis of the 2015 Korean Nationwide Cancer Registry , 2021, Journal of Liver Cancer.

[3]  K. Sung,et al.  Over 500 Liver Transplants Including More Than 400 Living-Donor Liver Transplants in 2019 at Asan Medical Center. , 2020, Transplantation proceedings.

[4]  H. Lee,et al.  Effectiveness and Safety of Nivolumab in Child–Pugh B Patients with Hepatocellular Carcinoma: A Real-World Cohort Study , 2020, Cancers.

[5]  J. Bruix,et al.  Local and Regional Therapies for Hepatocellular Carcinoma , 2020, Hepatology.

[6]  M. Abecassis,et al.  Diagnosis, Staging, and Management of Hepatocellular Carcinoma: 2018 Practice Guidance by the American Association for the Study of Liver Diseases , 2019, Clinical Liver Disease.

[7]  Wei Li,et al.  Safety and technical feasibility of percutaneous ablation for lymph node metastases of hepatocellular carcinoma , 2019, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[8]  J. Knox,et al.  Sorafenib as first-line therapy in patients with advanced Child-Pugh B hepatocellular carcinoma-a meta-analysis. , 2018, European journal of cancer.

[9]  M. Abecassis,et al.  Diagnosis, Staging, and Management of Hepatocellular Carcinoma: 2018 Practice Guidance by the American Association for the Study of Liver Diseases , 2018, Hepatology.

[10]  M. Kudo,et al.  Deterioration of liver function after transarterial chemoembolization (TACE) in hepatocellular carcinoma (HCC): An exploratory analysis of OPTIMIS—An international observational study assessing the use of sorafenib after TACE. , 2018 .

[11]  Seungbong Han,et al.  Temporal improvement in survival of patients with hepatocellular carcinoma in a hepatitis B virus‐endemic population , 2018, Journal of gastroenterology and hepatology.

[12]  T. Pawlik,et al.  Update on Liver Failure Following Hepatic Resection: Strategies for Prediction and Avoidance of Post-operative Liver Insufficiency , 2017, Journal of clinical and translational hepatology.

[13]  S. Shrikhande,et al.  Liver resection for HCC outside the BCLC criteria , 2018, Langenbeck's Archives of Surgery.

[14]  F. Carrilho,et al.  Adherence to BCLC recommendations for the treatment of hepatocellular carcinoma: impact on survival according to stage , 2017, Clinics.

[15]  J. Shindoh,et al.  Effect of Background Liver Cirrhosis on Outcomes of Hepatectomy for Hepatocellular Carcinoma , 2017, JAMA surgery.

[16]  J. Marrero,et al.  Observational registry of sorafenib use in clinical practice across Child-Pugh subgroups: The GIDEON study. , 2016, Journal of hepatology.

[17]  M. Saadeh,et al.  Liver , 2016, Laboratory Investigation.

[18]  D. Pinto dos Santos,et al.  Conventional transarterial chemoembolization versus drug-eluting bead transarterial chemoembolization for the treatment of hepatocellular carcinoma , 2015, BMC Cancer.

[19]  G. Song,et al.  Liver transplantation in Korea: past, present, and future. , 2015, Transplantation proceedings.

[20]  M. Kudo,et al.  Global patterns of hepatocellular carcinoma management from diagnosis to death: the BRIDGE Study , 2015, Liver international : official journal of the International Association for the Study of the Liver.

[21]  I. Hozo,et al.  When to perform hepatic resection for intermediate‐stage hepatocellular carcinoma , 2015, Hepatology.

[22]  Lequn Li,et al.  Hepatic Resection Associated With Good Survival for Selected Patients With Intermediate and Advanced-Stage Hepatocellular Carcinoma , 2014, Annals of surgery.

[23]  W. Lau,et al.  Partial hepatectomy vs. transcatheter arterial chemoembolization for resectable multiple hepatocellular carcinoma beyond Milan Criteria: a RCT. , 2014, Journal of hepatology.

[24]  Y. Sugawara,et al.  Living Donor Liver Transplantation for Patients with Hepatocellular Carcinoma , 2014, Liver Cancer.

[25]  C. Iancu,et al.  Treatment of hepatocellular carcinoma in a tertiary Romanian center. Deviations from BCLC recommendations and influence on survival rate. , 2013, Journal of gastrointestinal and liver diseases : JGLD.

[26]  R. Stauber,et al.  Advanced-stage hepatocellular carcinoma: transarterial chemoembolization versus sorafenib. , 2012, Radiology.

[27]  Patrick M M Bossuyt,et al.  Recommendations for liver transplantation for hepatocellular carcinoma: an international consensus conference report. , 2012, The Lancet. Oncology.

[28]  M. Zoli,et al.  Barcelona Clinic Liver Cancer staging and transplant survival benefit for patients with hepatocellular carcinoma: a multicentre, cohort study. , 2011, The Lancet. Oncology.

[29]  Sunggyu Lee,et al.  Liver transplantation for hepatocellular carcinoma: Korean experience , 2010, Journal of hepato-biliary-pancreatic sciences.

[30]  Sheung Tat Fan,et al.  Liver functional reserve estimation: state of the art and relevance for local treatments , 2010, Journal of hepato-biliary-pancreatic sciences.

[31]  Mi Young Kim,et al.  Multivariate Analysis of the Predictors of Survival for Patients with Hepatocellular Carcinoma Undergoing Transarterial Chemoembolization: Focusing on Superselective Chemoembolization , 2008, Korean journal of radiology.

[32]  G. Eknoyan,et al.  Definition and classification of chronic kidney disease: a position statement from Kidney Disease: Improving Global Outcomes (KDIGO). , 2005, Kidney international.

[33]  J. Marrero,et al.  Prognosis of hepatocellular carcinoma: Comparison of 7 staging systems in an American cohort , 2005, Hepatology.

[34]  W. Chapman,et al.  Comparison of MELD and Child-Pugh scores to predict survival after chemoembolization for hepatocellular carcinoma. , 2004, Journal of vascular and interventional radiology : JVIR.

[35]  Joong-Won Park [Practice guideline for diagnosis and treatment of hepatocellular carcinoma]. , 2004, The Korean journal of hepatology.

[36]  P. Schneider Preoperative assessment of liver function. , 2004, The Surgical clinics of North America.

[37]  L. Pączek,et al.  [Liver transplantation for hepatocellular carcinoma]. , 2003, Polskie Archiwum Medycyny Wewnetrznej.

[38]  R. Jordan,et al.  Molecular viral oncology of hepatocellular carcinoma , 2003, Oncogene.

[39]  G. Gasbarrini,et al.  Transarterial chemoembolization (TACE) for unresectable hepatocellular carcinoma in cirrhotics: functional hepatic reserve and survival. , 2003, Hepato-gastroenterology.

[40]  Ramon Planas,et al.  Arterial embolisation or chemoembolisation versus symptomatic treatment in patients with unresectable hepatocellular carcinoma: a randomised controlled trial , 2002, The Lancet.

[41]  John Wong,et al.  Randomized controlled trial of transarterial lipiodol chemoembolization for unresectable hepatocellular carcinoma , 2002, Hepatology.

[42]  S. Fan,et al.  Long-Term Survival and Pattern of Recurrence After Resection of Small Hepatocellular Carcinoma in Patients With Preserved Liver Function: Implications for a Strategy of Salvage Transplantation , 2002, Annals of surgery.

[43]  L. Ellis,et al.  Underlying liver disease, not tumor factors, predicts long-term survival after resection of hepatocellular carcinoma. , 2001, Archives of surgery.

[44]  A. Levey,et al.  A More Accurate Method To Estimate Glomerular Filtration Rate from Serum Creatinine: A New Prediction Equation , 1999, Annals of Internal Medicine.

[45]  J. Bruix,et al.  Prognosis of Hepatocellular Carcinoma: The BCLC Staging Classification , 1999, Seminars in liver disease.

[46]  R. Pugh,et al.  Transection of the oesophagus for bleeding oesophageal varices , 1973, The British journal of surgery.

[47]  M. Dumont,et al.  European Association for the Study of the Liver , 1971 .