Prediction of the Pharmacokinetics of Atorvastatin, Cerivastatin, and Indomethacin Using Kinetic Models Applied to Isolated Rat Hepatocytes
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Peter J H Webborn | Robert J Riley | R. Riley | S. Paine | Stuart W Paine | P. Webborn | P. Gardiner | A. J. Parker | Alison J Parker | Philip Gardiner
[1] B. Fleshler,et al. The Liver: Biology and Pathobiology , 1983 .
[2] J. Houston,et al. Uptake and Intracellular Binding of Lipophilic Amine Drugs by Isolated Rat Hepatocytes and Implications for Prediction of in Vivo Metabolic Clearance , 2006, Drug Metabolism and Disposition.
[3] J B Houston,et al. Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance. , 1994, Biochemical pharmacology.
[4] M. Rowland,et al. Prediction of in Vivo Tissue Distribution from in Vitro Data. 2. Correlation Between in Vitro and in Vivo Tissue Distribution of a Homologous Series of Nine 5-n-Alkyl-5-Ethyl Barbituric Acids , 2003, Pharmaceutical Research.
[5] Yau Yi Lau,et al. Development of a novel in vitro model to predict hepatic clearance using fresh, cryopreserved, and sandwich-cultured hepatocytes. , 2002, Drug metabolism and disposition: the biological fate of chemicals.
[6] Malcolm Rowland,et al. Physiologic modeling of cyclosporin kinetics in rat and man , 1991, Journal of Pharmacokinetics and Biopharmaceutics.
[7] J R Gillette. FACTORS AFFECTING DRUG METABOLISM , 1971, Annals of the New York Academy of Sciences.
[8] S. Khor,et al. Potential error in the measurement of tissue to blood distribution coefficients in physiological pharmacokinetic modeling. Residual tissue blood. II. Distribution of phencyclidine in the rat. , 1991, Drug metabolism and disposition: the biological fate of chemicals.
[9] K. Brouwer,et al. Localization of Pgp ( Abcb 1 ) and Mrp 2 ( Abcc 2 ) in Freshly Isolated Rat Hepatocytes , 2007 .
[10] E. Petzinger,et al. Evidence for a saturable, energy-dependent and carrier-mediated uptake of oral antidiabetics into rat hepatocytes. , 1992, European journal of pharmacology.
[11] R. Obach,et al. Drug Metabolizing Enzymes : Cytochrome P450 and Other Enzymes in Drug Discovery and Development , 2003 .
[12] R J Riley,et al. The impact of in vitro binding on in vitro-in vivo extrapolations, projections of metabolic clearance and clinical drug-drug interactions. , 2006, Current drug metabolism.
[13] Robert J Riley,et al. THE BINDING OF DRUGS TO HEPATOCYTES AND ITS RELATIONSHIP TO PHYSICOCHEMICAL PROPERTIES , 2005, Drug Metabolism and Disposition.
[14] P. McNamara,et al. Fraction unbound in interstitial fluid. , 1983, Journal of pharmaceutical sciences.
[15] K. Pang,et al. Effect of diffusional barriers on drug and metabolite kinetics. , 1987, Drug metabolism and disposition: the biological fate of chemicals.
[16] K. Sandy Pang,et al. Organ Clearance Concepts: New Perspectives on Old Principles , 1997, Journal of Pharmacokinetics and Biopharmaceutics.
[17] Y. Sugiyama,et al. Determination of the Rate-Limiting Step in the Hepatic Elimination of YM796 by Isolated Rat Hepatocytes , 2004, Pharmaceutical Research.
[18] K. Pang,et al. THE ROLES OF TRANSPORTERS AND ENZYMES IN HEPATIC DRUG PROCESSING , 2005, Drug Metabolism and Disposition.
[19] Grant R. Wilkinson,et al. A physiological approach to hepatic drug clearance , 1975 .
[20] Yuichi Sugiyama,et al. Evaluation of drug-drug interaction in the hepatobiliary and renal transport of drugs. , 2005, Annual review of pharmacology and toxicology.
[21] J B Houston,et al. Prediction of hepatic clearance from microsomes, hepatocytes, and liver slices. , 1997, Drug metabolism reviews.
[22] P. Seglen. Preparation of isolated rat liver cells. , 1976, Methods in cell biology.
[23] Y. Sugiyama,et al. Prediction of human hepatic clearance from in vivo animal experiments and in vitro metabolic studies with liver microsomes from animals and humans. , 2001, Drug metabolism and disposition: the biological fate of chemicals.
[24] B. Telfer,et al. Uptake of teicoplanin by isolated rat hepatocytes: comparison with in vivo hepatic distribution. , 2001, Drug metabolism and disposition: the biological fate of chemicals.
[25] Leslie Z. Benet,et al. PHARMACOKINETICS OF ATORVASTATIN AND ITS HYDROXY METABOLITES IN RATS AND THE EFFECTS OF CONCOMITANT RIFAMPICIN SINGLE DOSES: RELEVANCE OF FIRST-PASS EFFECT FROM HEPATIC UPTAKE TRANSPORTERS, AND INTESTINAL AND HEPATIC METABOLISM , 2006, Drug Metabolism and Disposition.
[26] A. Galetin,et al. Typical and Atypical Enzyme Kinetics , 2003 .
[27] Kiyomi Ito,et al. Comparison of the Use of Liver Models for Predicting Drug Clearance Using in Vitro Kinetic Data from Hepatic Microsomes and Isolated Hepatocytes , 2004, Pharmaceutical Research.
[28] G R Wilkinson,et al. Commentary: a physiological approach to hepatic drug clearance. , 1975, Clinical pharmacology and therapeutics.
[29] Kiyomi Ito,et al. Prediction of Human Drug Clearance from in Vitro and Preclinical Data Using Physiologically Based and Empirical Approaches , 2004, Pharmaceutical Research.
[30] K. Brouwer,et al. Hepatobiliary Disposition of the Metabolically Stable Opioid Peptide [d-Pen2, d-Pen5]-Enkephalin (DPDPE): Pharmacokinetic Consequences of the Interplay between Multiple Transport Systems , 2004, Journal of Pharmacology and Experimental Therapeutics.
[31] G. E. Searle,et al. APPLICATION OF A GENERIC PHYSIOLOGICALLY BASED PHARMACOKINETIC MODEL TO THE ESTIMATION OF XENOBIOTIC LEVELS IN RAT PLASMA , 2006, Drug Metabolism and Disposition.
[32] K. Brouwer,et al. Hepatobiliary Disposition of a Drug/Metabolite Pair: Comprehensive Pharmacokinetic Modeling in Sandwich-Cultured Rat Hepatocytes , 2006, Journal of Pharmacology and Experimental Therapeutics.
[33] A. Galetin,et al. Typical and atypical enzyme kinetics, in Drug metabolism enzymes: Cytochrome P450 and other enzymes in drug discovery and development. , 2003 .
[34] Leslie Z Benet,et al. Multiple Transporters Affect the Disposition of Atorvastatin and Its Two Active Hydroxy Metabolites: Application of in Vitro and ex Situ Systems , 2006, Journal of Pharmacology and Experimental Therapeutics.
[35] A. Evans. MEMBRANE TRANSPORT AS A DETERMINANT OF THE HEPATIC ELIMINATION OF DRUGS AND METABOLITES , 1996, Clinical and experimental pharmacology & physiology.
[36] Robert J Riley,et al. EVALUATION OF FRESH AND CRYOPRESERVED HEPATOCYTES AS IN VITRO DRUG METABOLISM TOOLS FOR THE PREDICTION OF METABOLIC CLEARANCE , 2004, Drug Metabolism and Disposition.
[37] K. Brouwer,et al. Localization of P-gp (Abcb1) and Mrp2 (Abcc2) in Freshly Isolated Rat Hepatocytes , 2008, Drug Metabolism and Disposition.
[38] R. Austin,et al. A UNIFIED MODEL FOR PREDICTING HUMAN HEPATIC, METABOLIC CLEARANCE FROM IN VITRO INTRINSIC CLEARANCE DATA IN HEPATOCYTES AND MICROSOMES , 2005, Drug Metabolism and Disposition.
[39] R J Riley,et al. In vitro–in vivo extrapolation of hepatic clearance involving active uptake: Theoretical and experimental aspects , 2007, Xenobiotica; the fate of foreign compounds in biological systems.
[40] A. Li,et al. Cryopreserved human hepatocytes: characterization of drug-metabolizing enzyme activities and applications in higher throughput screening assays for hepatotoxicity, metabolic stability, and drug-drug interaction potential. , 1999, Chemico-biological interactions.
[41] Ken Grime,et al. Use of Hepatocytes to Assess the Contribution of Hepatic Uptake to Clearance in Vivo , 2007, Drug Metabolism and Disposition.
[42] Y. Sugiyama,et al. In vitro and in vivo correlation of the inhibitory effect of cyclosporin A on the transporter-mediated hepatic uptake of cerivastatin in rats. , 2004, Drug metabolism and disposition: the biological fate of chemicals.
[43] Scott L Cockroft,et al. The influence of nonspecific microsomal binding on apparent intrinsic clearance, and its prediction from physicochemical properties. , 2002, Drug metabolism and disposition: the biological fate of chemicals.
[44] S. Khor,et al. Potential error in the measurement of tissue to blood distribution coefficients in physiological pharmacokinetic modeling. Residual tissue blood. I. Theoretical considerations. , 1991, Drug metabolism and disposition: the biological fate of chemicals.
[45] Malcolm Rowland,et al. Clearance concepts in pharmacokinetics , 1973, Journal of Pharmacokinetics and Biopharmaceutics.