Sweaty skin: an invitation to bite?

Anopheles gambiae sensu stricto and Aedes aegypti have a preference for human blood, which determines their importance as vectors of pathogens responsible for human diseases. Volatile organic chemicals are the principal cues by which humans are being located. Human sweat contains components that are attractive to anthropophilic mosquito species, and variation in sweat composition causes differential attractiveness to mosquitoes within and between individuals and also between humans and other mammals. Characteristics of skin glands and skin microbiota define the odorous organic compounds emitted by sweat, thereby the degree of attractiveness of the host to mosquitoes. Carboxylic acids in particular appear to characterize humans. Thus sweat-associated human volatiles are probably the primary determinant factor in the host preference of anthropophilic mosquitoes.

[1]  W. Takken,et al.  Interindividual variation in the attractiveness of human odours to the malaria mosquito Anopheles gambiae s. s. , 2006, Medical and veterinary entomology.

[2]  A. Natsch,et al.  Investigation of odors in the fragrance industry , 2010, Chemoecology.

[3]  D. Whitehead,et al.  Volatilization of ammonia from cattle urine applied to grassland , 1990 .

[4]  Richard H. Porter,et al.  Olfaction and human kin recognition , 1998, Genetica.

[5]  A. Cork,et al.  Identification of electrophysiologically‐active compounds for the malaria mosquito, Anopheles gambiae, in human sweat extracts , 1996, Medical and veterinary entomology.

[6]  G. Killeen,et al.  Potential Benefits, Limitations and Target Product-Profiles of Odor-Baited Mosquito Traps for Malaria Control in Africa , 2010, PloS one.

[7]  E. Scholte,et al.  Microbial growth enhances the attractiveness of human sweat for the malaria mosquito, Anopheles gambiae sensu stricto (Diptera: Culicidae) , 2000, CHEMOECOLOGY.

[8]  D. Barnard,et al.  Analysis of human skin emanations by gas chromatography/mass spectrometry. 2. Identification of volatile compounds that are candidate attractants for the yellow fever mosquito (Aedes aegypti). , 2000, Analytical chemistry.

[9]  D. Penn,et al.  Comparison of human axillary odour profiles obtained by gas chromatography/mass spectrometry and skin microbial profiles obtained by denaturing gradient gel electrophoresis using multivariate pattern recognition , 2007, Metabolomics.

[10]  D. Penn,et al.  Individual and gender fingerprints in human body odour , 2007, Journal of The Royal Society Interface.

[11]  P. Weldon,et al.  The scent of the reticulated giraffe (Giraffa camelopardalis reticulata) , 2002 .

[12]  Y. Michalakis,et al.  Malaria: Evolution in vector control , 2009, Nature.

[13]  M. Geier,et al.  Contribution of fatty acids to olfactory host finding of female Aedes aegypti. , 2000, Chemical senses.

[14]  G. Clark,et al.  Volatile compounds from the integument of White Leghorn Chickens (Gallus gallus domesticus L.): candidate attractants of ornithophilic mosquito species. , 2008, Journal of separation science.

[15]  M. Geier,et al.  L‐lactic acid: a human‐signifying host cue for the anthropophilic mosquito Anopheles gambiae , 2002, Medical and veterinary entomology.

[16]  A. G. James,et al.  Generation of volatile fatty acids by axillary bacteria 1 , 2004, International journal of cosmetic science.

[17]  Thomas Mammone,et al.  Gender-linked differences in human skin. , 2009, Journal of dermatological science.

[18]  Donald M. Broom,et al.  Analysis of human sweat volatiles: An example of pattern recognition in the analysis and interpretation of gas chromatograms , 1994 .

[19]  O. Bar-or,et al.  Effect of age and gender on sweat lactate and ammonia concentrations during exercise in the heat. , 2007, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.

[20]  F. Mcnabb,et al.  Proportions of ammonia, urea, urate and total nitrogen in avian urine and quantitative methods for their analysis on a single urine sample. , 1975, Poultry science.

[21]  R. Marples.  Sex, constancy, and skin bacteria , 2004, Archives of Dermatological Research.

[22]  Dengue and dengue haemorrhagic fever. 1990-1994. , 1995, Releve epidemiologique hebdomadaire.

[23]  D. Downing,et al.  Variation of skin surface lipid composition among mammals , 1981 .

[24]  R. Knight,et al.  Bacterial Community Variation in Human Body Habitats Across Space and Time , 2009, Science.

[25]  W. Takken,et al.  The response of the malaria mosquito, Anopheles gambiae, to two components of human sweat, ammonia and l‐lactic acid, in an olfactometer , 2001 .

[26]  R. Knight,et al.  Forensic identification using skin bacterial communities , 2010, Proceedings of the National Academy of Sciences.

[27]  F. Tomita,et al.  Foot odor due to microbial metabolism and its control. , 2006, Canadian journal of microbiology.

[28]  J. Schmid,et al.  A Broad Diversity of Volatile Carboxylic Acids, Released by a Bacterial Aminoacylase from Axilla Secretions, as Candidate Molecules for the Determination of Human‐Body Odor Type , 2006, Chemistry & biodiversity.

[29]  W. Takken,et al.  Host-seeking behaviour of mosquitoes: responses to olfactory stimuli in the laboratory. , 2010 .

[30]  M. Geier,et al.  The effect of lactic acid on odour-related host preference of yellow fever mosquitoes. , 2001, Chemical senses.

[31]  W. Takken,et al.  The Effect of Aliphatic Carboxylic Acids on Olfaction-Based Host-Seeking of the Malaria Mosquito Anopheles gambiae sensu stricto , 2009, Journal of Chemical Ecology.

[32]  S. Powers,et al.  Identification of Human-Derived Volatile Chemicals that Interfere with Attraction of Aedes aegypti Mosquitoes , 2008, Journal of Chemical Ecology.

[33]  G. Weisfeld,et al.  Possible olfaction-based mechanisms in human kin recognition and inbreeding avoidance. , 2003, Journal of experimental child psychology.

[34]  Michael Wilson,et al.  Bacteriology of Humans: An Ecological Perspective , 2008 .

[35]  N. Smith,et al.  Attractiveness of Men and Women to Aedes Aegypti and Relative Protection Time Obtained with Deet , 1966 .

[36]  D. G. Blackburn.  Evolutionary origins of the mammary gland , 1991 .

[37]  W. Noble,et al.  Colonization of the axilla by Propionibacterium avidum in relation to age , 1984, Applied and environmental microbiology.

[38]  T. Scott,et al.  Why Do Female Aedes aegypti (Diptera: Culicidae) Feed Preferentially and Frequently on Human Blood? , 2001, Journal of medical entomology.

[39]  W. Takken,et al.  Olfaction in vector-host interactions , 2010 .

[40]  Adee A. Schoon,et al.  The frequency of occurrence and discriminatory power of compounds found in human scent across a population determined by SPME-GC/MS. , 2007, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[41]  W. Takken,et al.  Chemical ecology of interactions between human skin microbiota and mosquitoes. , 2010, FEMS microbiology ecology.

[42]  W. Takken,et al.  Carbon dioxide chemotropism in mosquitoes (Diptera: Culicidae) and its potential in vector surveillance and management programmes. , 1997 .

[43]  P. Carnevale,et al.  Etude de l'agressivité d' Anopheles gambiae A en fonction de l'âge et du sexe des appâts humains , 1978 .

[44]  W. Takken,et al.  Malaria vector control: current and future strategies. , 2009, Trends in parasitology.

[45]  S ROBINSON,et al.  Chemical composition of sweat. , 1954, Physiological reviews.

[46]  A. Cox,et al.  Behavior of adult human skin in organ culture. II. Effects of cellophane tape stripping, temperature, oxygen tension, pH and serum. , 1968, The Journal of investigative dermatology.

[47]  J. Havlíček,et al.  Human Body Odour Individuality , 2008 .

[48]  W. Takken,et al.  Cultured skin microbiota attracts malaria mosquitoes , 2009, Malaria Journal.

[49]  N. Nicolaides,et al.  Skin Lipids: Their Biochemical Uniqueness , 1974, Science.

[50]  G. Folk,et al.  The evolution of sweat glands , 1991, International journal of biometeorology.

[51]  W. Takken,et al.  Development and Field Evaluation of a Synthetic Mosquito Lure That Is More Attractive than Humans , 2010, PloS one.

[52]  O. Wrong,et al.  Faecal ammonia and pH during lactulose administration in man: comparison with other cathartics , 1972, Gut.

[53]  Weltgesundheitsorganisation.  World malaria report , 2005 .

[54]  W. Takken,et al.  Odor-mediated behavior of Afrotropical malaria mosquitoes. , 1999, Annual review of entomology.

[55]  N. Nicolaides,et al.  The skin surface lipids of man compared with those of eighteen species of animals. , 1968, Journal of Investigative Dermatology.

[56]  C. Wysocki,et al.  Analyses of volatile organic compounds from human skin , 2008, The British journal of dermatology.

[57]  U. Bernier,et al.  Analysis of human skin emanations by gas chromatography/mass spectrometry. 1. Thermal desorption of attractants for the yellow fever mosquito (Aedes aegypti) from handled glass beads. , 1999, Analytical chemistry.

[58]  T. Perry,et al.  Volatile fatty acids in normal human physiological fluids. , 1970, Clinica chimica acta; international journal of clinical chemistry.

[59]  Duane J. Gubler,et al.  Dengue and Dengue Hemorrhagic Fever , 1998, Clinical Microbiology Reviews.

[60]  A. G. James,et al.  Fatty acid metabolism by cutaneous bacteria and its role in axillary malodour , 2004 .

[61]  Dietland Müller-Schwarze,et al.  Chemical Signals in Vertebrates 3 , 1983 .

[62]  Andrew I. Spielman,et al.  Analysis of characteristic human female axillary odors: Qualitative comparison to males , 1996, Journal of Chemical Ecology.