Efficacy and safety of perampanel monotherapy in patients with focal‐onset seizures with newly diagnosed epilepsy or recurrence of epilepsy after a period of remission: The open‐label Study 342 (FREEDOM Study)

Our study assessed perampanel monotherapy in patients (aged ≥12 years) with focal‐onset seizures (FOS) with or without focal to bilateral tonic‐clonic seizures (FBTCS) in Japan and South Korea.

[1]  B. Bourgeois,et al.  Practice guideline update summary: Efficacy and tolerability of the new antiepileptic drugs I: Treatment of new-onset epilepsy , 2018, Epilepsy currents.

[2]  T. Nishida,et al.  Adjunctive perampanel in partial‐onset seizures: Asia‐Pacific, randomized phase III study , 2018, Acta neurologica Scandinavica.

[3]  J. Ferry,et al.  Pharmacokinetic/pharmacodynamic analysis of adjunctive perampanel in subjects with partial‐onset seizures , 2018, Acta neurologica Scandinavica.

[4]  Josemir W Sander,et al.  A retrospective, multicentre study of perampanel given as monotherapy in routine clinical care in people with epilepsy , 2018, Seizure.

[5]  P. Kwan,et al.  Evaluation of perampanel as monotherapy for focal seizures: Experience from open-label extension studies , 2017, Epilepsy & Behavior Case Reports.

[6]  A. Chakraborty,et al.  Efficacy and Safety of Levetiracetam and Carbamazepine as Monotherapy in Partial Seizures , 2015, Epilepsy research and treatment.

[7]  J. Cramer,et al.  Is a separate monotherapy indication warranted for antiepileptic drugs? , 2015, The Lancet Neurology.

[8]  J. Ferry,et al.  Perampanel efficacy and tolerability with enzyme-inducing AEDs in patients with epilepsy , 2015, Neurology.

[9]  P. Patsalos.  The clinical pharmacology profile of the new antiepileptic drug perampanel: A novel noncompetitive AMPA receptor antagonist , 2015, Epilepsia.

[10]  M. Baulac,et al.  Long‐term safety and efficacy of zonisamide versus carbamazepine monotherapy for treatment of partial seizures in adults with newly diagnosed epilepsy: Results of a phase III, randomized, double‐blind study , 2014, Epilepsia.

[11]  J. Ferry,et al.  Concentration–effect relationships with perampanel in patients with pharmacoresistant partial‐onset seizures , 2013, Epilepsia.

[12]  B. Bourgeois,et al.  Updated ILAE evidence review of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes , 2013, Epilepsia.

[13]  B. Steinhoff,et al.  Evaluation of adjunctive perampanel in patients with refractory partial‐onset seizures: Results of randomized global phase III study 305 , 2013, Epilepsia.

[14]  G. Krauss,et al.  Adjunctive perampanel for refractory partial-onset seizures , 2012, Neurology.

[15]  J D Norrie,et al.  Patterns of treatment response in newly diagnosed epilepsy , 2012, Neurology.

[16]  S. Hatakeyama,et al.  Perampanel: A novel, orally active, noncompetitive AMPA‐receptor antagonist that reduces seizure activity in rodent models of epilepsy , 2011, Epilepsia.

[17]  N. Sethi,et al.  COMPARISON OF LEVETIRACETAM AND CONTROLLED-RELEASE CARBAMAZEPINE IN NEWLY DIAGNOSED EPILEPSY , 2007, Neurology.

[18]  P Ryvlin,et al.  Comparison of levetiracetam and controlled-release carbamazepine in newly diagnosed epilepsy , 2007, Neurology.

[19]  D. Naritoku,et al.  Randomized dose‐controlled study of topiramate as first‐line therapy in epilepsy , 2005, Acta neurologica Scandinavica.

[20]  S. Ellenberg.  Food and Drug Administration (FDA) , 2005 .

[21]  T. Alsaadi,et al.  Levetiracetam monotherapy for newly diagnosed epilepsy patients , 2003, Seizure.

[22]  P. Kwan,et al.  Early identification of refractory epilepsy. , 2000, The New England journal of medicine.

[23]  D. Chadwick.  Safety and efficacy of vigabatrin and carbamazepine in ne wly diagnosed epilepsy: a multicentre randomised double-blind study , 1999, The Lancet.

[24]  R. Elwes,et al.  Phenobarbitone, phenytoin, carbamazepine, or sodium valproate for newly diagnosed adult epilepsy: a randomised comparative monotherapy trial. , 1995, Journal of neurology, neurosurgery, and psychiatry.

[25]  P. Joensen,et al.  Clonazepam (Rivotril®) and Carbamazepine (Tegretol®) in Psychomotor Epilepsy: A Randomized Multicenter Trial , 1981, Epilepsia.

[26]  S. Kaneko,et al.  A Phase III, Multicenter, Randomized, Open-label Study of Levetiracetam Monotherapy in Japanese Patients with Partial Onset Seizures , 2015 .

[27]  S. Hong,et al.  Lamotrigine monotherapy in newly diagnosed epilepsy or recurrent epilepsy: A multi-center, open-label study , 2014 .

[28]  G. Krauss,et al.  Adjunctive perampanel for refractory partial-onset seizures , 2012 .