Non-coding DNA variants for risk in lupus.
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[1] Xianjun Yu,et al. Epigenetic regulation in the tumor microenvironment: molecular mechanisms and therapeutic targets , 2023, Signal transduction and targeted therapy.
[2] L. Looger,et al. Genome-wide association study for systemic lupus erythematosus in an egyptian population , 2022, Frontiers in Genetics.
[3] Yongfei Wang,et al. Integrative Functional Genomics Identifies Systemic Lupus Erythematosus Causal Genetic Variant in the IRF5 Risk Locus , 2022, Arthritis & rheumatology.
[4] Q. Lu,et al. Global epidemiology of systemic lupus erythematosus: a comprehensive systematic analysis and modelling study , 2022, Annals of the Rheumatic Diseases.
[5] M. Weirauch,et al. Lupus enhancer risk variant causes dysregulation of IRF8 through cooperative lncRNA and DNA methylation machinery , 2022, Nature Communications.
[6] Y. Lau,et al. Identification of Shared and Asian‐Specific Loci for Systemic Lupus Erythematosus and Evidence for Roles of Type III Interferon Signaling and Lysosomal Function in the Disease: A Multi‐Ancestral Genome‐Wide Association Study , 2021, Arthritis & rheumatology.
[7] A. Reinisch,et al. Targeted regulation of transcription in primary cells using CRISPRa and CRISPRi , 2021, Genome research.
[8] P. Gaffney,et al. Variants on the UBE2L3/YDJC Autoimmune Disease Risk Haplotype Increase UBE2L3 Expression by Modulating CCCTC‐Binding Factor and YY1 Binding , 2021, Arthritis & rheumatology.
[9] Ryan M. Layer,et al. A complete reference genome improves analysis of human genetic variation , 2021, bioRxiv.
[10] Nathan S. Abell,et al. Multiple Causal Variants Underlie Genetic Associations in Humans , 2021, bioRxiv.
[11] L. Looger,et al. Lupus Susceptibility Region Containing CDKN1B rs34330 Mechanistically Influences Expression and Function of Multiple Target Genes, Also Linked to Proliferation and Apoptosis , 2021, Arthritis & rheumatology.
[12] Y. Okada,et al. Dynamic landscape of immune cell-specific gene regulation in immune-mediated diseases , 2021, Cell.
[13] Daniel E. Miller,et al. Global discovery of lupus genetic risk variant allelic enhancer activity , 2021, Nature Communications.
[14] Jiangshan J. Shen,et al. Identification of 38 novel loci for systemic lupus erythematosus and genetic heterogeneity between ancestral groups , 2021, Nature Communications.
[15] Y. Lau,et al. Genome-wide association study on Northern Chinese identifies KLF2, DOT1L and STAB2 associated with systemic lupus erythematosus. , 2021, Rheumatology.
[16] David K. Yang,et al. Genome-wide functional screen of 3′UTR variants uncovers causal variants for human disease and evolution , 2021, Cell.
[17] Amanda M Li,et al. CRISPR-Cas9 Gene Editing for Sickle Cell Disease and β-Thalassemia. , 2020, The New England journal of medicine.
[18] M. Weirauch,et al. Meta-analysis of 208370 East Asians identifies 113 susceptibility loci for systemic lupus erythematosus , 2020, Annals of the Rheumatic Diseases.
[19] Dmitry D. Penzar,et al. Landscape of allele-specific transcription factor binding in the human genome , 2020, Nature Communications.
[20] Jay Shendure,et al. A systematic evaluation of the design and context dependencies of massively parallel reporter assays , 2020, Nature Methods.
[21] Xuejun Zhang,et al. Independent Replication on Genome-Wide Association Study Signals Identifies IRF3 as a Novel Locus for Systemic Lupus Erythematosus , 2020, Frontiers in Genetics.
[22] M. Weirauch,et al. SLE non-coding genetic risk variant determines the epigenetic dysfunction of an immune cell specific enhancer that controls disease-critical microRNA expression , 2020, bioRxiv.
[23] Carl G. de Boer,et al. Prioritizing disease and trait causal variants at the TNFAIP3 locus using functional and genomic features , 2020, Nature Communications.
[24] A. Pombo,et al. Methods for mapping 3D chromosome architecture , 2019, Nature Reviews Genetics.
[25] P. Gaffney,et al. Role of Systemic Lupus Erythematosus Risk Variants With Opposing Functional Effects as a Driver of Hypomorphic Expression of TNIP1 and Other Genes Within a Three‐Dimensional Chromatin Network , 2019, Arthritis & rheumatology.
[26] B. Liu,et al. Inhibition of histone deacetylase 1 (HDAC1) and HDAC2 enhances CRISPR/Cas9 genome editing , 2019, bioRxiv.
[27] D. Absher,et al. Genome-wide association study meta-analysis identifies five new loci for systemic lupus erythematosus , 2018, Arthritis Research & Therapy.
[28] X. Zuo,et al. Genome‐wide association study identifies three novel susceptibility loci for systemic lupus erythematosus in Han Chinese , 2018, The British journal of dermatology.
[29] Matthew C. Canver,et al. High-Throughput Approaches to Pinpoint Function within the Noncoding Genome. , 2017, Molecular cell.
[30] P. Gregersen,et al. Transancestral mapping and genetic load in systemic lupus erythematosus , 2017, Nature Communications.
[31] Jianzhong Su,et al. Targeted DNA methylation in vivo using an engineered dCas9-MQ1 fusion protein , 2017, Nature Communications.
[32] Yang I Li,et al. An Expanded View of Complex Traits: From Polygenic to Omnigenic , 2017, Cell.
[33] Giacomo Cavalli,et al. Organization and function of the 3D genome , 2016, Nature Reviews Genetics.
[34] P. Gaffney,et al. Genome-wide association meta-analysis in Chinese and European individuals identifies ten new loci associated with systemic lupus erythematosus , 2016, Nature Genetics.
[35] Y. J. Kim,et al. High-density genotyping of immune-related loci identifies new SLE risk variants in individuals with Asian ancestry , 2016, Nature Genetics.
[36] P. Gaffney,et al. Identification of a New Susceptibility Locus for Systemic Lupus Erythematosus on Chromosome 12 in Individuals of European Ancestry , 2016, Arthritis & rheumatology.
[37] P. Gaffney,et al. Identification of a Systemic Lupus Erythematosus Risk Locus Spanning ATG16L2, FCHSD2, and P2RY2 in Koreans , 2015, Arthritis & rheumatology.
[38] P. Gaffney,et al. Genome‐Wide Association Study in an Amerindian Ancestry Population Reveals Novel Systemic Lupus Erythematosus Risk Loci and the Role of European Admixture , 2015, Arthritis & rheumatology.
[39] J. Rioux,et al. Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus , 2015, Nature Genetics.
[40] Eytan Zlotorynski. Plant development: A fruit-bearing microRNA , 2015, Nature Reviews Molecular Cell Biology.
[41] Jiangshan J. Shen,et al. Genome-wide search followed by replication reveals genetic interaction of CD80 and ALOX5AP associated with systemic lupus erythematosus in Asian populations , 2015, Annals of the rheumatic diseases.
[42] R. Maehr,et al. Functional annotation of native enhancers with a Cas9 -histone demethylase fusion , 2015, Nature Methods.
[43] Michael Q. Zhang,et al. Integrative analysis of 111 reference human epigenomes , 2015, Nature.
[44] Alexandro E. Trevino,et al. Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex , 2014, Nature.
[45] Bjoern Peters,et al. Epigenomic analysis of primary human T cells reveals enhancers associated with TH2 memory cell differentiation and asthma susceptibility , 2014, Nature Immunology.
[46] M. Peters,et al. Systematic identification of trans eQTLs as putative drivers of known disease associations , 2013, Nature Genetics.
[47] P. Gaffney,et al. An Enhancer Element Harboring Variants Associated with Systemic Lupus Erythematosus Engages the TNFAIP3 Promoter to Influence A20 Expression , 2013, PLoS genetics.
[48] Luke A. Gilbert,et al. CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes , 2013, Cell.
[49] H. Lähdesmäki,et al. Global chromatin state analysis reveals lineage-specific enhancers during the initiation of human T helper 1 and T helper 2 cell polarization. , 2013, Immunity.
[50] E. Dermitzakis,et al. Expression quantitative trait loci: present and future , 2013, Philosophical Transactions of the Royal Society B: Biological Sciences.
[51] Luke A. Gilbert,et al. Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression , 2013, Cell.
[52] Le Cong,et al. Multiplex Genome Engineering Using CRISPR/Cas Systems , 2013, Science.
[53] P. Sham,et al. Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians. , 2013, American journal of human genetics.
[54] Shane J. Neph,et al. Systematic Localization of Common Disease-Associated Variation in Regulatory DNA , 2012, Science.
[55] James B. Brown,et al. Modeling gene expression using chromatin features in various cellular contexts , 2012, Genome Biology.
[56] Raymond K. Auerbach,et al. An Integrated Encyclopedia of DNA Elements in the Human Genome , 2012, Nature.
[57] P. Gaffney,et al. Identification of IRF8, TMEM39A, and IKZF3-ZPBP2 as susceptibility loci for systemic lupus erythematosus in a large-scale multiracial replication study. , 2012, American journal of human genetics.
[58] Y. Okada,et al. A Genome-Wide Association Study Identified AFF1 as a Susceptibility Locus for Systemic Lupus Eyrthematosus in Japanese , 2012, PLoS genetics.
[59] A. Syvänen,et al. Association of NCF2, IKZF1, IRF8, IFIH1, and TYK2 with Systemic Lupus Erythematosus , 2011, PLoS genetics.
[60] Nan Shen,et al. A Functional Variant in MicroRNA-146a Promoter Modulates Its Expression and Confers Disease Risk for Systemic Lupus Erythematosus , 2011, PLoS genetics.
[61] Liangdan Sun,et al. Follow-up study identifies two novel susceptibility loci PRKCB and 8p11.21 for systemic lupus erythematosus. , 2011, Rheumatology.
[62] Annette Lee,et al. Differential Genetic Associations for Systemic Lupus Erythematosus Based on Anti–dsDNA Autoantibody Production , 2011, PLoS genetics.
[63] P. Sham,et al. Two missense variants in UHRF1BP1 are independently associated with systemic lupus erythematosus in Hong Kong Chinese , 2011, Genes and Immunity.
[64] P. Sham,et al. ELF1 is associated with systemic lupus erythematosus in Asian populations. , 2011, Human molecular genetics.
[65] Liangdan Sun,et al. Polymorphisms at 16p13 are associated with systemic lupus erythematosus in the Chinese population , 2010, Journal of Medical Genetics.
[66] P. Visscher,et al. Common SNPs explain a large proportion of the heritability for human height , 2010, Nature Genetics.
[67] P. Sham,et al. Genome-Wide Association Study in Asian Populations Identifies Variants in ETS1 and WDFY4 Associated with Systemic Lupus Erythematosus , 2010, PLoS genetics.
[68] Annette Lee,et al. A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus , 2009, Nature Genetics.
[69] Ying Wang,et al. Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus , 2009, Nature Genetics.
[70] P. Park. ChIP–seq: advantages and challenges of a maturing technology , 2009, Nature Reviews Genetics.
[71] P. Tak,et al. MicroRNA-146A contributes to abnormal activation of the type I interferon pathway in human lupus by targeting the key signaling proteins. , 2009, Arthritis and rheumatism.
[72] M. Daly,et al. Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus , 2008, Nature Genetics.
[73] Geoffrey Hom,et al. Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX. , 2008, The New England journal of medicine.
[74] Marta E Alarcón-Riquelme,et al. Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci , 2008, Nature Genetics.
[75] Sandra D'Alfonso,et al. Functional variants in the B-cell gene BANK1 are associated with systemic lupus erythematosus , 2008, Nature Genetics.
[76] L. Hellman,et al. Electrophoretic mobility shift assay (EMSA) for detecting protein–nucleic acid interactions , 2007, Nature Protocols.
[77] D. Baltimore,et al. NF-κB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses , 2006, Proceedings of the National Academy of Sciences.
[78] Marta E Alarcón-Riquelme,et al. Familial aggregation of systemic lupus erythematosus, rheumatoid arthritis, and other autoimmune diseases in 1,177 lupus patients from the GLADEL cohort. , 2005, Arthritis and rheumatism.
[79] Glinda S Cooper,et al. Risk factors for development of systemic lupus erythematosus: allergies, infections, and family history. , 2002, Journal of clinical epidemiology.
[80] J. Dekker,et al. Capturing Chromosome Conformation , 2002, Science.
[81] T. Mack,et al. A revised estimate of twin concordance in systemic lupus erythematosus. , 1992, Arthritis and rheumatism.
[82] J. Kaprio,et al. Systemic lupus erythematosus and related systemic diseases in a nationwide twin cohort: an increased prevalence of disease in MZ twins and concordance of disease features , 1992, Journal of internal medicine.
[83] F. Arnett,et al. STUDIES IN FAMILIAL SYSTEMIC LUPUS ERYTHEMATOSUS , 1976, Medicine.
[84] M. Lockshin,et al. Studies of twins with systemic lupus erythematosus. A review of the literature and presentation of 12 additional sets. , 1975, The American journal of medicine.
[85] T. Leonhardt. FAMILIAL HYPERGAMMAGLOBULINÆMIA AND SYSTEMIC LUPUS ERYTHEMATOSUS , 1957 .
[86] M. Allende. Lupus erythematosus, discoid and systemic: one disease. , 1956, Postgraduate medicine.
[87] International Human Genome Sequencing Consortium. Initial sequencing and analysis of the human genome , 2001, Nature.