Left ventricular hypertrophy or storage disease? the incremental value of speckle tracking strain bull's‐eye

Left ventricular hypertrophy (LVH) develops in response to a variety of physical, genetic, and biochemical stimuli and represents the early stage of ventricular remodeling. In patients with LVH, subclinical left ventricular (LV) dysfunction despite normal ejection fraction (EF) may be present before the onset of symptoms, which portends a dismal prognosis. Strain measurement with two‐dimensional speckle tracking echocardiography (STE) represents a highly reproducible and accurate alternative to LVEF determination. The present review focuses on current available evidence that supports the incremental value of STE in the diagnostic and prognostic workup of LVH. When assessing the components of LV contraction, STE has an incremental value in differentiating between primary and secondary LVH and in the differential diagnosis with storage diseases. In addition, STE provides unique information for the stratification of patients with LVH, enabling to detect intrinsic myocardial dysfunction before LVEF reduction.

[1]  M. Ferrone,et al.  Determinants of myocardial mechanics in top-level endurance athletes: three-dimensional speckle tracking evaluation , 2016, European heart journal cardiovascular Imaging.

[2]  O. Rimoldi,et al.  From Left Ventricular Hypertrophy to Dysfunction and Failure. , 2016, Circulation journal : official journal of the Japanese Circulation Society.

[3]  T. Edvardsen,et al.  Strain echocardiography is related to fibrosis and ventricular arrhythmias in hypertrophic cardiomyopathy , 2016, European heart journal cardiovascular Imaging.

[4]  J. Moon,et al.  Global longitudinal strain is associated with heart failure outcomes in hypertrophic cardiomyopathy , 2016, Heart.

[5]  G. Limongelli,et al.  Anabolic-androgenic steroids and athlete's heart: When big is not beautiful....! , 2016, International journal of cardiology.

[6]  B. Bijnens,et al.  Left Ventricular Geometry and Blood Pressure as Predictors of Adverse Progression of Fabry Cardiomyopathy , 2015, PloS one.

[7]  Jose Angel Urbano-Moral,et al.  Ecocardiografía speckle tracking (rastreo de marcas) tridimensional en la amiloidosis cardiaca de cadenas ligeras: estudio de los parámetros de mecánica miocárdica ventricular izquierda y derecha , 2015 .

[8]  N. Pandian,et al.  Three-dimensional Speckle Tracking Echocardiography in Light Chain Cardiac Amyloidosis: Examination of Left and Right Ventricular Myocardial Mechanics Parameters. , 2015, Revista espanola de cardiologia.

[9]  M. Galderisi,et al.  The role of new echocardiographic techniques in athlete’s heart , 2015, F1000Research.

[10]  F. Cacciapuoti.  The role of echocardiography in the non-invasive diagnosis of cardiac amyloidosis , 2015, Journal of Echocardiography.

[11]  R. Cocchia,et al.  Effects of Transcatheter Aortic Valve Implantation on Left Ventricular and Left Atrial Morphology and Function , 2015, Echocardiography.

[12]  Victor Mor-Avi,et al.  Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. , 2015, European heart journal cardiovascular Imaging.

[13]  A. Kovács,et al.  Comparison of left ventricular mechanics in runners versus bodybuilders using speckle tracking echocardiography , 2015, Cardiovascular Ultrasound.

[14]  C. Autore,et al.  Patterns of left ventricular longitudinal strain and strain rate in Olympic athletes. , 2015, Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography.

[15]  Martin Borggrefe,et al.  [2014 ESC Guidelines on diagnosis and management of hypertrophic cardiomyopathy]. , 2014, Kardiologia polska.

[16]  P. Sengupta,et al.  LV mechanics in mitral and aortic valve diseases: value of functional assessment beyond ejection fraction. , 2014, JACC. Cardiovascular imaging.

[17]  F. Rutten,et al.  2014 ESC Guidelines on diagnosis and management of hypertrophic cardiomyopathy: the Task Force for the Diagnosis and Management of Hypertrophic Cardiomyopathy of the European Society of Cardiology (ESC). , 2014, European heart journal.

[18]  Y. Sohn,et al.  Improvement of cardiac function by short-term enzyme replacement therapy in a murine model of cardiomyopathy associated with Hunter syndrome evaluated by serial echocardiography with speckle tracking 2-D strain analysis. , 2014, Molecular genetics and metabolism.

[19]  Natesa G Pandian,et al.  Investigation of Global and Regional Myocardial Mechanics With 3-Dimensional Speckle Tracking Echocardiography and Relations to Hypertrophy and Fibrosis in Hypertrophic Cardiomyopathy , 2014, Circulation. Cardiovascular imaging.

[20]  Jeroen J. Bax,et al.  2007 ESH-ESC Guidelines for the management of arterial hypertension: the task force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). , 2007, Blood pressure.

[21]  L. Badano,et al.  Incremental value of three-dimensional strain imaging in Danon disease. , 2012, European heart journal cardiovascular Imaging.

[22]  G. de Simone,et al.  Correlates of global area strain in native hypertensive patients: a three-dimensional speckle-tracking echocardiography study. , 2012, European heart journal cardiovascular Imaging.

[23]  James D. Thomas,et al.  Relative apical sparing of longitudinal strain using two-dimensional speckle-tracking echocardiography is both sensitive and specific for the diagnosis of cardiac amyloidosis , 2012, Heart.

[24]  E. Donal,et al.  Clinical outcome in asymptomatic severe aortic stenosis: insights from the new proposed aortic stenosis grading classification. , 2012, Journal of the American College of Cardiology.

[25]  Erwan Donal,et al.  Low-Flow, Low-Gradient Severe Aortic Stenosis Despite Normal Ejection Fraction Is Associated With Severe Left Ventricular Dysfunction as Assessed by Speckle-Tracking Echocardiography: A Multicenter Study , 2012, Circulation. Cardiovascular imaging.

[26]  H. Ihlen,et al.  Detection of left ventricular dysfunction by global longitudinal systolic strain in patients with chronic aortic regurgitation. , 2011, Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography.

[27]  C. Saitta,et al.  Left Ventricular Function in Hypertension: New Insight by Speckle Tracking Echocardiography , 2011, Echocardiography.

[28]  O. Nielsen,et al.  Speckle-tracking echocardiography for predicting outcome in chronic aortic regurgitation during conservative management and after surgery. , 2011, JACC. Cardiovascular imaging.

[29]  Victor Mor-Avi,et al.  Current and evolving echocardiographic techniques for the quantitative evaluation of cardiac mechanics: ASE/EAE consensus statement on methodology and indications endorsed by the Japanese Society of Echocardiography. , 2011, European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology.

[30]  K. George,et al.  Upper limits of physiological cardiac adaptation in ultramarathon runners. , 2011, Journal of the American College of Cardiology.

[31]  Donato Mele,et al.  Speckle‐Tracking Echocardiography , 2011, Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine.

[32]  D. Mele,et al.  Differences of myocardial systolic deformation and correlates of diastolic function in competitive rowers and young hypertensives: a speckle-tracking echocardiography study. , 2010, Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography.

[33]  F. Pieruzzi,et al.  [Cardiological follow-up in patients with Fabry disease]. , 2010, Giornale italiano di cardiologia.

[34]  D. Mele,et al.  Echocardiography in patients with hypertrophic cardiomyopathy: usefulness of old and new techniques in the diagnosis and pathophysiological assessment , 2010, Cardiovascular ultrasound.

[35]  E. Donal,et al.  Impact of global left ventricular afterload on left ventricular function in asymptomatic severe aortic stenosis: a two-dimensional speckle-tracking study. , 2010, European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology.

[36]  C. Hollak,et al.  Vasculopathy in patients with Fabry disease: current controversies and research directions. , 2010, Molecular genetics and metabolism.

[37]  A. DeMaria,et al.  Impact of impaired myocardial deformations on exercise tolerance and prognosis in patients with asymptomatic aortic stenosis. , 2009, European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology.

[38]  M. Sayed,et al.  Doping and effects of anabolic androgenic steroids on the heart: histological, ultrastructural, and echocardiographic assessment in strength athletes , 2009, Human & experimental toxicology.

[39]  L. Pierard,et al.  Importance of left ventricular longitudinal function and functional reserve in patients with degenerative mitral regurgitation: assessment by two-dimensional speckle tracking. , 2008, Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography.

[40]  Krishnaswamy Chandrasekaran,et al.  Twist mechanics of the left ventricle: principles and application. , 2008, JACC. Cardiovascular imaging.

[41]  M. Jahangiri,et al.  Changes in systolic left ventricular function in isolated mitral regurgitation. A strain rate imaging study. , 2007, European heart journal.

[42]  P. dos Santos,et al.  An ultrasound speckle tracking (two-dimensional strain) analysis of myocardial deformation in professional soccer players compared with healthy subjects and hypertrophic cardiomyopathy. , 2007, The American journal of cardiology.

[43]  P. Pibarot,et al.  Paradoxical Low-Flow, Low-Gradient Severe Aortic Stenosis Despite Preserved Ejection Fraction Is Associated With Higher Afterload and Reduced Survival , 2007, Circulation.

[44]  G. Di Salvo,et al.  Left ventricular early myocardial dysfunction after chronic misuse of anabolic androgenic steroids: a Doppler myocardial and strain imaging analysis , 2006, British Journal of Sports Medicine.

[45]  J. Sandstede,et al.  The variation of morphological and functional cardiac manifestation in Fabry disease: potential implications for the time course of the disease. , 2005, European heart journal.

[46]  T. Marwick,et al.  Prediction of subclinical left ventricular dysfunction with strain rate imaging in patients with asymptomatic severe mitral regurgitation. , 2004, The American journal of cardiology.

[47]  J. Schaper,et al.  Progression From Compensated Hypertrophy to Failure in the Pressure-Overloaded Human Heart: Structural Deterioration and Compensatory Mechanisms , 2003, Circulation.

[48]  B. Lorell,et al.  Left ventricular hypertrophy: pathogenesis, detection, and prognosis. , 2000, Circulation.

[49]  O. Hess,et al.  Left Ventricular Passive Diastolic Properties in Chronic Mitral Regurgitation , 1991, Circulation.

[50]  M. Proschan,et al.  The upper limit of physiologic cardiac hypertrophy in highly trained elite athletes. , 1991, The New England journal of medicine.

[51]  W. Henry,et al.  Comparative left ventricular dimensions in trained athletes. , 1975, Annals of internal medicine.