Native valve endocarditis due to coagulase-negative staphylococci: report of 99 episodes from the International Collaboration on Endocarditis Merged Database.

Using a large cohort of patients from the International Collaboration on Endocarditis Merged Database, we compared coagulase-negative staphylococcal (CoNS) native-valve endocarditis (NVE) to NVE caused by more common pathogens. Rates of heart failure and mortality were similar between patients with CoNS NVE and patients with Staphylococcus aureus NVE, but rates for both groups were significantly higher than rates for patients with NVE due to viridans streptococci. These results emphasize the importance of CoNS as a cause of NVE and the potential for serious complications with this infection.

[1]  S. Ben Redjeb,et al.  [Coagulase-negative staphylococcal endocarditis]. , 1987, La Tunisie medicale.

[2]  R. Gaynes,et al.  Nosocomial infections in medical intensive care units in the United States. National Nosocomial Infections Surveillance System. , 1999, Critical care medicine.

[3]  D. Mannino,et al.  The epidemiology of sepsis in the United States from 1979 through 2000. , 2003, The New England journal of medicine.

[4]  C. Cabell,et al.  Progress toward a global understanding of infective endocarditis. Early lessons from the International Collaboration on Endocarditis investigation. , 2002, Infectious disease clinics of North America.

[5]  R. Wenzel,et al.  Coagulase-negative staphylococcal bacteremia. Mortality and hospital stay , 1990 .

[6]  M. Rupp,et al.  Coagulase-negative staphylococci: pathogens associated with medical progress. , 1994, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[7]  G. Archer,et al.  Native valve endocarditis due to coagulase-negative staphylococci. Clinical and microbiologic features. , 1987, The American journal of medicine.

[8]  R. Wenzel,et al.  Hospital-acquired bloodstream infections with Staphylococcus epidermidis. Review of 100 cases. , 1984, The American journal of medicine.

[9]  A. Karchmer,et al.  Endocarditis due to coagulase-negative staphylococci. Microbiologic, epidemiologic, and clinical considerations. , 1993, Infectious disease clinics of North America.

[10]  D. Durack,et al.  New criteria for diagnosis of infective endocarditis: utilization of specific echocardiographic findings. Duke Endocarditis Service. , 1994, The American journal of medicine.

[11]  W. J. Martin,et al.  Coagulase-negative staphylococcal bacteremia in patients receiving immunosuppressive therapy. , 1983, Archives of internal medicine.

[12]  S. Eykyn,et al.  Increase in native valve endocarditis caused by coagulase negative staphylococci: an Anglo-French clinical and microbiological study. , 1990, British heart journal.

[13]  D. Goldmann,et al.  Coagulase-negative staphylococci: role as pathogens. , 1999, Annual review of medicine.

[14]  A. Bisno,et al.  Nosocomial septicemia due to multiply antibiotic-resistant Staphylococcus epidermidis. , 1982, Annals of internal medicine.

[15]  A. Jm.  Native valve endocarditis caused by Staphylococcus epidermidis , 1989 .

[16]  H. O'Shields,et al.  Coagulase-Negative Staphylococcal Endocarditis: A View From the Community Hospital , 1986, Southern medical journal.

[17]  Daniel J Sexton,et al.  Health CareAssociated Bloodstream Infections in Adults: A Reason To Change the Accepted Definition of Community-Acquired Infections , 2002, Annals of Internal Medicine.

[18]  N. Arber,et al.  Native valve Staphylococcus epidermidis endocarditis: report of seven cases and review of the literature. , 1991, The American journal of medicine.

[19]  Vance G Fowler,et al.  Changing patient characteristics and the effect on mortality in endocarditis. , 2002, Archives of internal medicine.

[20]  S. Goldstein,et al.  Seven cases of surgical native valve endocarditis caused by coagulase-negative staphylococci: An underappreciated disease. , 2001, American heart journal.