NFATc1 expression in the developing heart valves is responsive to the RANKL pathway and is required for endocardial expression of cathepsin K.

[1]  D. Srivastava,et al.  Mutations in NOTCH1 cause aortic valve disease , 2005, Nature.

[2]  T. Kodama,et al.  NFAT and Osterix cooperatively regulate bone formation , 2005, Nature Medicine.

[3]  K. Horiuchi,et al.  Evaluation of the contributions of ADAMs 9, 12, 15, 17, and 19 to heart development and ectodomain shedding of neuregulins beta1 and beta2. , 2005, Developmental biology.

[4]  B. Rothermel,et al.  Restoration of DSCR1 to disomy in the trisomy 16 mouse model of Down syndrome does not correct cardiac or craniofacial development anomalies , 2005, Developmental dynamics : an official publication of the American Association of Anatomists.

[5]  Svetlana V Komarova,et al.  Convergent signaling by acidosis and receptor activator of NF-kappaB ligand (RANKL) on the calcium/calcineurin/NFAT pathway in osteoclasts. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[6]  M. Karsdal,et al.  Acidification of the osteoclastic resorption compartment provides insight into the coupling of bone formation to bone resorption. , 2005, The American journal of pathology.

[7]  S. Hagl,et al.  Influence of receptor activator of nuclear factor kappa B on human aortic valve myofibroblasts. , 2005, Experimental and molecular pathology.

[8]  Li Sun,et al.  RANK-L induces the expression of NFATc1, but not of NFkappaB subunits during osteoclast formation. , 2004, Biochemical and biophysical research communications.

[9]  Raymond B. Runyan,et al.  Cell biology of cardiac cushion development. , 2005, International review of cytology.

[10]  S. Théoleyre,et al.  The molecular triad OPG/RANK/RANKL: involvement in the orchestration of pathophysiological bone remodeling. , 2004, Cytokine & growth factor reviews.

[11]  P. Collin‐Osdoby.  Regulation of Vascular Calcification by Osteoclast Regulatory Factors RANKL and Osteoprotegerin , 2004, Circulation research.

[12]  B. Horne,et al.  Evidence for a Heritable Component in Death Resulting From Aortic and Mitral Valve Diseases , 2004, Circulation.

[13]  Y. Nogi,et al.  Essential Role of p38 Mitogen-activated Protein Kinase in Cathepsin K Gene Expression during Osteoclastogenesis through Association of NFATc1 and PU.1* , 2004, Journal of Biological Chemistry.

[14]  I. Graef,et al.  A Field of Myocardial-Endocardial NFAT Signaling Underlies Heart Valve Morphogenesis , 2004, Cell.

[15]  H. Aburatani,et al.  Nuclear Factor of Activated T-cells (NFAT) Rescues Osteoclastogenesis in Precursors Lacking c-Fos* , 2004, Journal of Biological Chemistry.

[16]  D. Towler,et al.  Osteogenic regulation of vascular calcification: an early perspective. , 2004, American journal of physiology. Endocrinology and metabolism.

[17]  J. Woo,et al.  The Calcineurin/Nuclear Factor of Activated T Cells Signaling Pathway Regulates Osteoclastogenesis in RAW264.7 Cells* , 2004, Journal of Biological Chemistry.

[18]  K. Yutzey,et al.  DSCR1 gene expression is dependent on NFATc1 during cardiac valve formation and colocalizes with anomalous organ development in trisomy 16 mice. , 2004, Developmental biology.

[19]  G. Nicholson,et al.  Gene array identification of osteoclast genes: Differential inhibition of osteoclastogenesis by cyclosporin A and granulocyte macrophage colony stimulating factor , 2004, Journal of cellular biochemistry.

[20]  Sakae Tanaka,et al.  Critical roles of c-Jun signaling in regulation of NFAT family and RANKL-regulated osteoclast differentiation. , 2004, The Journal of clinical investigation.

[21]  S. Hagl,et al.  Receptor activator of nuclear factor κB ligand and osteoprotegerin regulate aortic valve calcification , 2004 .

[22]  David Sedmera,et al.  Developmental anatomy of the heart: a tale of mice and man. , 2003, Physiological genomics.

[23]  Lin Chen,et al.  Transcriptional regulation by calcium, calcineurin, and NFAT. , 2003, Genes & development.

[24]  David C. Lee,et al.  Form and function of developing heart valves: coordination by extracellular matrix and growth factor signaling , 2003, Journal of Molecular Medicine.

[25]  M. Walsh,et al.  Biology of the TRANCE axis. , 2003, Cytokine & growth factor reviews.

[26]  David C. Lee,et al.  Defective valvulogenesis in HB‐EGF and TACE‐null mice is associated with aberrant BMP signaling , 2003, The EMBO journal.

[27]  J. Desgrosellier,et al.  Early events in valvulogenesis: a signaling perspective. , 2003, Birth defects research. Part C, Embryo today : reviews.

[28]  F. Schoen,et al.  NFATc1 Mediates Vascular Endothelial Growth Factor-induced Proliferation of Human Pulmonary Valve Endothelial Cells* , 2003, Journal of Biological Chemistry.

[29]  Hiroshi Takayanagi,et al.  Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts. , 2002, Developmental cell.

[30]  T. Takeya,et al.  Large Scale Gene Expression Analysis of Osteoclastogenesisin Vitro and Elucidation of NFAT2 as a Key Regulator* , 2002, The Journal of Biological Chemistry.

[31]  M. Nemer,et al.  Cooperative interaction between GATA5 and NF-ATc regulates endothelial-endocardial differentiation of cardiogenic cells. , 2002, Development.

[32]  S. Rivkees,et al.  Neuregulin-1 promotes formation of the murine cardiac conduction system , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[33]  J. Hoffman,et al.  The incidence of congenital heart disease. , 2002, Journal of the American College of Cardiology.

[34]  G. Crabtree,et al.  NFAT Signaling Choreographing the Social Lives of Cells , 2002, Cell.

[35]  Yufang Shi,et al.  Regulation of activation‐induced receptor activator of NF‐κB ligand (RANKL) expression in T cells , 2002, European journal of immunology.

[36]  Yufang Shi,et al.  Differential Regulation of the Expression of CD95 Ligand, Receptor Activator of Nuclear Factor-κB Ligand (RANKL), TNF-Related Apoptosis-Inducing Ligand (TRAIL), and TNF-α During T Cell Activation1 2 , 2001, The Journal of Immunology.

[37]  X. Luo,et al.  Differential regulation of the expression of CD95 ligand, receptor activator of nuclear factor-kappa B ligand (RANKL), TNF-related apoptosis-inducing ligand (TRAIL), and TNF-alpha during T cell activation. , 2001, Journal of immunology.

[38]  Wanmin Song,et al.  Degradation of type IV collagen by matrix metalloproteinases is an important step in the epithelial-mesenchymal transformation of the endocardial cushions. , 2000, Developmental biology.

[39]  D. Lacey,et al.  The Osteoclast Differentiation Factor Osteoprotegerin-Ligand Is Essential for Mammary Gland Development , 2000, Cell.

[40]  D L Lacey,et al.  RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[41]  I. Kola,et al.  Cathepsin K Knockout Mice Develop Osteopetrosis Due to a Deficit in Matrix Degradation but Not Demineralization , 1999, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[42]  L. Lum,et al.  Evidence for a Role of a Tumor Necrosis Factor-α (TNF-α)-converting Enzyme-like Protease in Shedding of TRANCE, a TNF Family Member Involved in Osteoclastogenesis and Dendritic Cell Survival* , 1999, Journal of Biological Chemistry.

[43]  S. Morony,et al.  Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[44]  S. Morony,et al.  OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis , 1999, Nature.

[45]  L. Lum,et al.  Evidence for a role of a tumor necrosis factor-alpha (TNF-alpha)-converting enzyme-like protease in shedding of TRANCE, a TNF family member involved in osteoclastogenesis and dendritic cell survival. , 1999, The Journal of biological chemistry.

[46]  H. Yasuda,et al.  RANK is the essential signaling receptor for osteoclast differentiation factor in osteoclastogenesis. , 1998, Biochemical and biophysical research communications.

[47]  P. Delmas,et al.  The Collagenolytic Activity of Cathepsin K Is Unique among Mammalian Proteinases* , 1998, The Journal of Biological Chemistry.

[48]  K Yano,et al.  Severe osteoporosis in mice lacking osteoclastogenesis inhibitory factor/osteoprotegerin. , 1998, Biochemical and biophysical research communications.

[49]  Hao Ren,et al.  Regulation of the Calmodulin-stimulated Protein Phosphatase, Calcineurin* , 1998, The Journal of Biological Chemistry.

[50]  S. Morony,et al.  osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification. , 1998, Genes & development.

[51]  D. Lacey,et al.  Osteoprotegerin Ligand Is a Cytokine that Regulates Osteoclast Differentiation and Activation , 1998, Cell.

[52]  K Yano,et al.  Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[53]  Michael J. Grusby,et al.  The transcription factor NF-ATc is essential for cardiac valve formation , 1998, Nature.

[54]  Tak W. Mak,et al.  Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum , 1998, Nature.

[55]  S. Mochizuki,et al.  Identity of osteoclastogenesis inhibitory factor (OCIF) and osteoprotegerin (OPG): a mechanism by which OPG/OCIF inhibits osteoclastogenesis in vitro. , 1998, Endocrinology.

[56]  P. McGuire,et al.  Spatial and temporal expression of the 72‐kDa type IV collagenase (MMP‐2) correlates with development and differentiation of valves in the embryonic avian heart , 1997, Developmental dynamics : an official publication of the American Association of Anatomists.

[57]  G Shimamoto,et al.  Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density , 1997, Cell.

[58]  Jian Zhang,et al.  Cathepsin K: isolation and characterization of the murine cDNA and genomic sequence, the homologue of the human pycnodysostosis gene. , 1996, Biochemical and molecular medicine.

[59]  M. Polymeropoulos,et al.  A nonsense mutation in the cathepsin K gene observed in a family with pycnodysostosis. , 1996, Genome research.

[60]  A. Feeney,et al.  Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities. , 1996, The EMBO journal.

[61]  D. Mcnulty,et al.  Proteolytic Activity of Human Osteoclast Cathepsin K , 1996, The Journal of Biological Chemistry.

[62]  J. Icardo,et al.  Atrioventricular valves of the mouse: II. Light and transmission electron microscopy , 1995, The Anatomical record.

[63]  S. Gordon,et al.  Macrophages in haemopoietic and other tissues of the developing mouse detected by the monoclonal antibody F4/80. , 1991, Development.

[64]  R. Baron,et al.  Cell-mediated extracellular acidification and bone resorption: evidence for a low pH in resorbing lacunae and localization of a 100-kD lysosomal membrane protein at the osteoclast ruffled border , 1985, The Journal of cell biology.

[65]  Y. Missirlis,et al.  Ultrastructure of the human aortic valve. , 1977, Acta anatomica.