A prospective, randomized study using transdermal electromotive administration of verapamil and dexamethasone for Peyronie's disease.

PURPOSE Uncontrolled studies with intraplaque electromotive administration of verapamil and dexamethasone have demonstrated objective improvements in Peyronie's disease. We performed a prospective controlled study to assess the efficacy of intraplaque electromotive verapamil/dexamethasone vs electromotive lidocaine. MATERIALS AND METHODS Patients with Peyronie's disease were randomized into a study group (47 patients) and a control group (49 patients). For each treatment session an electrode receptacle was sited over the plaque and filled with either 5 mg verapamil and 8 mg dexamethasone (study group) or 2% lidocaine (control group), and a 2.4 mA electric current was applied for 20 minutes. All patients were scheduled for 4 sessions per week for 6 weeks. Assessment before and after treatment included measurements of plaque volume and penile curvature, and pain on erection (from questionnaire). RESULTS A total of 37 patients in the study group and 36 in the control group completed treatment courses. In the study group there were significant decreases in median plaque volume from 824 to 348 mm, and in penile curvature from 43 to 21 degrees. In the control group median volume and curvature were unchanged. The difference in results after treatment between the 2 groups was also significant. Significant pain relief occurred in both groups, transient in the control group and permanent in the study group. All patients experienced temporary erythema at the electrode site. There were no other side effects. CONCLUSIONS Intraplaque electromotive verapamil and dexamethasone induce substantial objective improvement in Peyronie's disease compared to electromotive lidocaine administration.

[1]  W. Hellstrom,et al.  935: Single-Blind, Multi-Center, Placebo-Controlled, Parallel Study to Assess the Safety and Efficacy of Intralesional Interferon Alpha-2b in the Nonsurgical Treatment of Peyronie's Disease , 2005 .

[2]  A. Giannantoni,et al.  Transdermal electromotive administration of verapamil and dexamethasone for Peyronie's disease , 2003, BJU international.

[3]  L. Levine,et al.  Tunica albuginea tissue analysis after electromotive drug administration. , 2003, The Journal of urology.

[4]  W. Linehan,et al.  Diagnostic localization of malignant bladder pheochromocytoma using 6-18F fluorodopamine positron emission tomography. , 2003, The Journal of urology.

[5]  L. Levine,et al.  Experience with intraplaque injection of verapamil for Peyronie's disease. , 2002, The Journal of urology.

[6]  T. Shankey,et al.  Inhibition of Peyronie's plaque fibroblast proliferation by biologic agents , 2000, International Journal of Impotence Research.

[7]  W. Hellstrom,et al.  Peyronie's disease: etiology, medical, and surgical therapy. , 2000, Journal of andrology.

[8]  F. Montorsi,et al.  Transdermal electromotive multi-drug administration for Peyronie's disease: preliminary results. , 2000, Journal of andrology.

[9]  C. Riedl,et al.  Iontophoresis for treatment of Peyronie's disease. , 2000, The Journal of urology.

[10]  P. Erne,et al.  Ca2+ channel blockers modulate metabolism of collagens within the extracellular matrix. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[11]  I. Fishman,et al.  Case report. lontophoretic delivery of steroids in the treatment of Peyronie's disease: case reports of three successful outcomes , 1994 .

[12]  S. Jacobsen,et al.  Iontophoresis of dexamethasone: laboratory studies , 1992 .

[13]  V. Pilipović-Ećim,et al.  [Peyronie's disease]. , 1989, Acta chirurgica Iugoslavica.

[14]  Yie W. Chien,et al.  Iontophoretic delivery of drugs: Fundamentals, developments and biomedical applications , 1988 .

[15]  A. Kelâmi Classification of congenital and acquired penile deviation. , 1983, Urologia internationalis.

[16]  S. Bauer,et al.  Prognostic value of urodynamic testing in myelodysplastic patients. , 1981, The Journal of urology.

[17]  J. Williams,et al.  The natural history of Peyronie's disease. , 1970, The Journal of urology.

[18]  J. Williams,et al.  The Natural History of Peyronie's Disease , 1968, Proceedings of the Royal Society of Medicine.

[19]  W. Murray,et al.  The treatment of Peyronie's disease by iontophoresis of C21 esterified glucocortocoids. , 1967, The Journal of urology.