Association between severe eczema in children and multiple comorbid conditions and increased healthcare utilization

Atopic dermatitis (AD) is associated with multiple comorbid conditions, such as asthma and food allergy. We sought to determine the impact of eczema severity on the development of these disorders and other non‐atopic comorbidities in AD.

[1]  S. Ziegler,et al.  Thymic stromal lymphopoietin (TSLP)-mediated dermal inflammation aggravates experimental asthma , 2012, Mucosal Immunology.

[2]  M. D. de Bruin‐Weller,et al.  Moderate correlation between quality of life and disease activity in adult patients with atopic dermatitis , 2012, Journal of the European Academy of Dermatology and Venereology : JEADV.

[3]  J. Marinković,et al.  Health‐related quality of life in patients with atopic dermatitis , 2012, The Journal of dermatology.

[4]  F. Arcangeli,et al.  Quality of life measures in Italian children with atopic dermatitis and their families , 2011, Italian journal of pediatrics.

[5]  P. Magin,et al.  Correlation and agreement of self‐assessed and objective skin disease severity in a cross‐sectional study of patients with acne, psoriasis, and atopic eczema , 2011, International journal of dermatology.

[6]  E. Cho,et al.  Association of polymorphisms in genes encoding IL‐4, IL‐13 and their receptors with atopic dermatitis in a Korean population , 2011, Experimental dermatology.

[7]  G. Ciprandi,et al.  TLR2 and TLR4 Gene Polymorphisms and Atopic Dermatitis in Italian Children: A Multicenter Study , 2011, International journal of immunopathology and pharmacology.

[8]  G. Giles,et al.  Childhood eczema and rhinitis predict atopic but not nonatopic adult asthma: a prospective cohort study over 4 decades. , 2011, The Journal of allergy and clinical immunology.

[9]  Brooke Bair,et al.  Cataracts in atopic dermatitis: a case presentation and review of the literature. , 2011, Archives of dermatology.

[10]  E. Cho,et al.  An association between IL-9 and IL-9 receptor gene polymorphisms and atopic dermatitis in a Korean population. , 2011, Journal of dermatological science.

[11]  Ahmad A. Al Robaee,et al.  Impairment quality of life in families of children with atopic dermatitis. , 2010, Acta dermatovenerologica Croatica : ADC.

[12]  W. Kirch,et al.  Outpatient care and medical treatment of children and adults with atopic eczema , 2009, Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG.

[13]  D. Johns,et al.  Childhood eczema and asthma incidence and persistence: a cohort study from childhood to middle age. , 2008, The Journal of allergy and clinical immunology.

[14]  F. Baroody,et al.  Filaggrin expression in oral, nasal, and esophageal mucosa. , 2008, The Journal of investigative dermatology.

[15]  Y. Ohya,et al.  Dental Caries and Allergic Disorders in Japanese Children: The Ryukyus Child Health Study , 2008, The Journal of asthma : official journal of the Association for the Care of Asthma.

[16]  J. Carlin,et al.  Association of cord blood cytokine production with wheezy infants in the first year of life , 2007, The Journal of allergy and clinical immunology.

[17]  H. Klip,et al.  Risk of developing asthma in young children with atopic eczema: a systematic review. , 2007, The Journal of allergy and clinical immunology.

[18]  P. Nafstad,et al.  Acute otitis media in schoolchildren: allergic diseases and skin prick test positivity , 2007, Acta oto-laryngologica.

[19]  D. Zeldin,et al.  Oral pathogens and allergic disease: results from the Third National Health and Nutrition Examination Survey. , 2006, The Journal of allergy and clinical immunology.

[20]  E. Baldi,et al.  Long-term follow-up of atopic dermatitis: retrospective analysis of related risk factors and association with concomitant allergic diseases. , 2006, Journal of the American Academy of Dermatology.

[21]  U. John,et al.  Inverse association between periodontitis and respiratory allergies , 2006, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[22]  Kari L. Nysse-Carris,et al.  Design and Operation of the National Survey of Children's Health, 2003. , 2005, Vital and health statistics. Ser. 1, Programs and collection procedures.

[23]  B. Niggemann,et al.  The natural course of atopic dermatitis from birth to age 7 years and the association with asthma. , 2004, The Journal of allergy and clinical immunology.

[24]  A. Yamada,et al.  Early sensitization to house dust mite is a major risk factor for subsequent development of bronchial asthma in Japanese infants with atopic dermatitis: results of a 4-year followup study. , 2002, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

[25]  H. Williams,et al.  What is the cost of atopic dermatitis in preschool children? , 2001, The British journal of dermatology.

[26]  J. Sears,et al.  Atopic dermatitis: a case report and current clinical review of systemic and ocular manifestations. , 2001, Optometry.

[27]  J. Istvan,et al.  The prevalence of atopic dermatitis in Oregon schoolchildren. , 2000, Journal of the American Academy of Dermatology.

[28]  C. Herrick,et al.  Th2 responses induced by epicutaneous or inhalational protein exposure are differentially dependent on IL-4. , 2000, The Journal of clinical investigation.

[29]  D. Gustafsson,et al.  Development of allergies and asthma in infants and young children with atopic dermatitis – a prospective follow‐up to 7 years of age , 2000, Allergy.

[30]  Schäfer,et al.  The influence of cultural and educational factors on the validity of symptom and diagnosis questions for atopic eczema , 1998, The British journal of dermatology.

[31]  Asher,et al.  The International Study of Asthma and Allergies in Childhood (ISAAC) , 1998, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[32]  Richard Beasley,et al.  Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema: ISAAC , 1998, The Lancet.

[33]  R. Geha,et al.  Epicutaneous sensitization with protein antigen induces localized allergic dermatitis and hyperresponsiveness to methacholine after single exposure to aerosolized antigen in mice. , 1998, The Journal of clinical investigation.

[34]  B. Cohen,et al.  Prevalence of IgE-Mediated Food Allergy Among Children With Atopic Dermatitis , 1998, Pediatrics.

[35]  B. Kjellman,et al.  Allergy in early and late onset of atopic dermatitis , 1994, Acta paediatrica.

[36]  D. Hoss,et al.  Inflammatory and papulosquamous disorders of the skin and eye. , 1992, Dermatologic clinics.

[37]  H. Clausen,et al.  Immunohistochemical analysis of stratum corneum components in oral squamous epithelia. , 1989, Differentiation; research in biological diversity.

[38]  S. A. Smith,et al.  Immunologic localization of filaggrin in human oral epithelia and correlation with keratinization. , 1986, The Journal of investigative dermatology.

[39]  H. Sampson,et al.  Food hypersensitivity and atopic dermatitis: evaluation of 113 patients. , 1985, The Journal of pediatrics.

[40]  F. F. Castrow.  Atopic cataracts versus steroid cataracts. , 1981, Journal of the American Academy of Dermatology.

[41]  R. Stern,et al.  Utilization of physician services for dermatologic complaints. The United States, 1974. , 1977, Archives of dermatology.

[42]  R. Thompson.  Cataract with atopic dermatitis; dermatologic aspects, with special reference to preoperative and postoperative care. , 1950, Archives of dermatology and syphilology.

[43]  A. Torrelo,et al.  Atopic dermatitis: impact on quality of life and patients' attitudes toward its management. , 2012, European journal of dermatology : EJD.

[44]  L. Beck,et al.  Atopic dermatitis: a disease caused by innate immune defects? , 2009, The Journal of investigative dermatology.

[45]  O. Alho,et al.  Cow's milk allergy is associated with recurrent otitis media during childhood. , 1999, Acta oto-laryngologica.

[46]  A. Burks,et al.  Atopic dermatitis and food hypersensitivity reactions. , 1998, The Journal of pediatrics.

[47]  Y. Benjamini,et al.  Controlling the false discovery rate: a practical and powerful approach to multiple testing , 1995 .

[48]  J. Hanifin,et al.  Ocular Complications of Atopic Dermatitis and Other Eczemas , 1985, International ophthalmology clinics.

[49]  T. Amemiya,et al.  Ocular findings in atopic dermatitis with special reference to the clinical features of atopic cataract. , 1980, Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde.