Systems analysis of miRNA biomarkers to inform drug safety

[1]  M. Halushka,et al.  miR-21: a non‐specific biomarker of all maladies , 2021, Biomarker research.

[2]  D. Webb,et al.  Circulating argonaute-bound microRNA-126 reports vascular dysfunction and treatment response in acute and chronic kidney disease , 2020, iScience.

[3]  M. Hölttä,et al.  Urinary Kidney Biomarker Panel Detects Preclinical Antisense Oligonucleotide-Induced Tubular Toxicity , 2020, Toxicologic pathology.

[4]  Qiao Yang,et al.  Identification and expression profile of microRNA in seven tissues of the Golden snub-nosed monkey (Rhinopithecus roxellanae) , 2020, Molecular Genetics and Genomics.

[5]  E. Herzog,et al.  Evaluation of urinary biomarkers for early detection of acute kidney injury in a rat nephropathy model. , 2020, Journal of pharmacological and toxicological methods.

[6]  F. Sistare,et al.  Evaluation of 10 Urinary Biomarkers for Renal Safety With 5 Nephrotoxicants in Nonhuman Primates , 2020, Toxicologic pathology.

[7]  David M. Rissin,et al.  Direct detection of miR-122 in hepatotoxicity using dynamic chemical labelling overcomes stability and isomiR challenges. , 2020, Analytical chemistry.

[8]  C. Gieger,et al.  Impact of long-term storage and freeze-thawing on eight circulating microRNAs in plasma samples , 2020, PloS one.

[9]  Dominic P. Williams,et al.  Transfer of hepatocellular microRNA regulates cytochrome P450 2E1 in renal tubular cells , 2020, bioRxiv.

[10]  Jens Allmer,et al.  Detection of pre-microRNA with Convolutional Neural Networks , 2019, bioRxiv.

[11]  A. Valsesia,et al.  Genome-wide identification of circulating-miRNA expression quantitative trait loci reveals the role of several miRNAs in the regulation of Cardiometabolic phenotypes. , 2019, Cardiovascular research.

[12]  Veronika A. Herzog,et al.  Time-Resolved Small RNA Sequencing Unravels the Molecular Principles of MicroRNA Homeostasis. , 2019, Molecular cell.

[13]  J. Vogt,et al.  Variance component analysis of circulating miR-122 in serum from healthy human volunteers , 2019, PloS one.

[14]  J. Castell,et al.  A novel microRNA signature for cholestatic drugs in human hepatocytes and its translation into novel circulating biomarkers for drug-induced liver injury patients. , 2019, Toxicological sciences : an official journal of the Society of Toxicology.

[15]  V. de Guire,et al.  How close are miRNAs from clinical practice? A perspective on the diagnostic and therapeutic market , 2019, EJIFCC.

[16]  C. Edelstein,et al.  Biomarkers of Drug-Induced Kidney Toxicity , 2022 .

[17]  J. Arora,et al.  Biogenesis and biological implications of isomiRs in mammals- a review , 2019, ExRNA.

[18]  G. Banfi,et al.  Normalization strategies differently affect circulating miRNA profile associated with the training status , 2019, Scientific Reports.

[19]  Diego A. Calvopina,et al.  Serum MicroRNAs as Biomarkers in Hepatitis C: Preliminary Evidence of a MicroRNA Panel for the Diagnosis of Hepatocellular Carcinoma , 2019, International journal of molecular sciences.

[20]  Qinyu Ge,et al.  MicroRNA Detection Specificity: Recent Advances and Future Perspective. , 2019, Analytical chemistry.

[21]  I. Rezende.  Total RNA extraction , 2019 .

[22]  P. Watkins,et al.  Serum biomarkers of drug‐induced liver injury: Current status and future directions , 2018, Journal of digestive diseases.

[23]  F. Sistare,et al.  A Performance Evaluation of Liver and Skeletal Muscle-Specific miRNAs in Rat Plasma to Detect Drug-Induced Injury , 2018, Toxicological sciences : an official journal of the Society of Toxicology.

[24]  Raegan B O'Lone,et al.  RATEmiRs: the rat atlas of tissue-specific and enriched miRNAs database , 2018, BMC Genomics.

[25]  M. A. Fara,et al.  A PCR-free technology to detect and quantify microRNAs directly from human plasma. , 2018, The Analyst.

[26]  Ana Kozomara,et al.  miRBase: from microRNA sequences to function , 2018, Nucleic Acids Res..

[27]  J. Castell,et al.  Non-invasive prediction of NAFLD severity: a comprehensive, independent validation of previously postulated serum microRNA biomarkers , 2018, Scientific Reports.

[28]  Jiri Aubrecht,et al.  Candidate biomarkers for the diagnosis and prognosis of drug‐induced liver injury: An international collaborative effort , 2018, Hepatology.

[29]  Guiqing Jia,et al.  Droplet digital PCR-based circulating microRNA detection serve as a promising diagnostic method for gastric cancer , 2018, BMC Cancer.

[30]  Hamid Alinejad-Rokny,et al.  A data-driven, knowledge-based approach to biomarker discovery: application to circulating microRNA markers of colorectal cancer prognosis , 2018, npj Systems Biology and Applications.

[31]  J. Jen,et al.  A Comprehensive Approach to Sequence-oriented IsomiR annotation (CASMIR): demonstration with IsomiR profiling in colorectal neoplasia , 2018, BMC Genomics.

[32]  L. Xue,et al.  Circulating microRNAs as potential cancer biomarkers: the advantage and disadvantage , 2018, Clinical Epigenetics.

[33]  S. Verhulst,et al.  Prospects in non-invasive assessment of liver fibrosis: Liquid biopsy as the future gold standard? , 2018, Biochimica et biophysica acta. Molecular basis of disease.

[34]  P. Leedman,et al.  Total RNA extraction from tissues for microRNA and target gene expression analysis: not all kits are created equal , 2018, BMC Biotechnology.

[35]  S. Seliger,et al.  The Cardiac Troponin Renal Disease Diagnostic Conundrum: Past, Present, and Future , 2018, Circulation.

[36]  C. Matthews,et al.  Intra-individual variation of miRNA expression levels in human plasma samples , 2018, Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.

[37]  W. Bailey,et al.  Accessible miRNAs as Novel Toxicity Biomarkers , 2018, International journal of toxicology.

[38]  B. K. Park,et al.  MiR-122 and other microRNAs as potential circulating biomarkers of drug-induced liver injury , 2018, Expert review of molecular diagnostics.

[39]  Jinwen Yu,et al.  Increased miR‐124‐3p in microglial exosomes following traumatic brain injury inhibits neuronal inflammation and contributes to neurite outgrowth via their transfer into neurons , 2018, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[40]  J. Grillari,et al.  MicroRNAs and toxicology: A love marriage , 2017, Toxicology reports.

[41]  L. Leocani,et al.  Multiple biomarkers improve the prediction of multiple sclerosis in clinically isolated syndromes , 2017, Acta neurologica Scandinavica.

[42]  M. Johnson,et al.  Circulating miR-122 and miR-200a as biomarkers for fatal liver disease in ART-treated, HIV-1-infected individuals , 2017, Scientific Reports.

[43]  Jay W. Shin,et al.  An integrated expression atlas of miRNAs and their promoters in human and mouse , 2017, Nature Biotechnology.

[44]  W. Krzyzosiak,et al.  Stress-induced changes in miRNA biogenesis and functioning , 2017, Cellular and Molecular Life Sciences.

[45]  Xiaoli Zhu,et al.  Detection of microRNA: A Point-of-Care Testing Method Based on a pH-Responsive and Highly Efficient Isothermal Amplification. , 2017, Analytical chemistry.

[46]  J. Kleinjans,et al.  Serum microRNA signatures as "liquid biopsies" for interrogating hepatotoxic mechanisms and liver pathogenesis in human , 2017, PloS one.

[47]  R. Fontana,et al.  Profiles of miRNAs in serum in severe acute drug induced liver injury and their prognostic significance , 2017, Liver international : official journal of the International Association for the Study of the Liver.

[48]  S. Brandão,et al.  New Imaging Methods for Detection of Drug-Induced Cardiotoxicity in Cancer Patients , 2017, Current Cardiovascular Imaging Reports.

[49]  G. Fonarow,et al.  The Role of Biomarkers in Detection of Cardio-toxicity , 2017, Current Oncology Reports.

[50]  Michael Merz,et al.  Drug-induced liver injury: recent advances in diagnosis and risk assessment , 2017, Gut.

[51]  J. Dear,et al.  MicroRNA‐122 can be measured in capillary blood which facilitates point‐of‐care testing for drug‐induced liver injury , 2017, British journal of clinical pharmacology.

[52]  Nagendra Kumar Singh,et al.  miRNAs target databases: developmental methods and target identification techniques with functional annotations , 2017, Cellular and Molecular Life Sciences.

[53]  S. Kääb,et al.  Stability of Circulating Blood-Based MicroRNAs – Pre-Analytic Methodological Considerations , 2017, PloS one.

[54]  M. Masè,et al.  Selection of reference genes is critical for miRNA expression analysis in human cardiac tissue. A focus on atrial fibrillation , 2017, Scientific Reports.

[55]  M. Mayr,et al.  MicroRNA Biomarkers and Platelet Reactivity: The Clot Thickens , 2017, Circulation research.

[56]  M. Waldenberger,et al.  Blood hsa-miR-122-5p and hsa-miR-885-5p levels associate with fatty liver and related lipoprotein metabolism—The Young Finns Study , 2016, Scientific Reports.

[57]  R. T. Bunch,et al.  MicroRNA as biomarkers of mitochondrial toxicity. , 2016, Toxicology and applied pharmacology.

[58]  M. Sohel,et al.  Extracellular/Circulating MicroRNAs: Release Mechanisms, Functions and Challenges , 2016 .

[59]  H. Tilg,et al.  Circulating MicroRNA-122 Is Associated With the Risk of New-Onset Metabolic Syndrome and Type 2 Diabetes , 2016, Diabetes.

[60]  Qingzhao Li,et al.  Early Predictors of Acute Kidney Injury: A Narrative Review , 2016, Kidney and Blood Pressure Research.

[61]  Xinya Chen,et al.  Increased Brain-Specific MiR-9 and MiR-124 in the Serum Exosomes of Acute Ischemic Stroke Patients , 2016, PloS one.

[62]  P. Bushel,et al.  The Rat microRNA body atlas; Evaluation of the microRNA content of rat organs through deep sequencing and characterization of pancreas enriched miRNAs as biomarkers of pancreatic toxicity in the rat and dog , 2016, BMC Genomics.

[63]  L. Altucci,et al.  MicroRNA-34a regulates doxorubicin-induced cardiotoxicity in rat , 2016, Oncotarget.

[64]  C. Stephens,et al.  Biomarkers in DILI: One More Step Forward , 2016, Front. Pharmacol..

[65]  D. Noonan,et al.  A comparison between quantitative PCR and droplet digital PCR technologies for circulating microRNA quantification in human lung cancer , 2016, BMC Biotechnology.

[66]  S. Tirrell,et al.  The beagle dog MicroRNA tissue atlas: identifying translatable biomarkers of organ toxicity , 2016, BMC Genomics.

[67]  Juliette J. Kahle,et al.  MicroRNA Biomarkers of Toxicity in Biological Matrices. , 2016, Toxicological sciences : an official journal of the Society of Toxicology.

[68]  F. Piva,et al.  The choice of endogenous controls in exosomal microRNA assessments from biofluids , 2016, Tumor Biology.

[69]  A. Darzi,et al.  Elevated serum microRNA 483-5p levels may predict patients at risk of post-operative atrial fibrillation , 2016, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery.

[70]  M. Pavkovic,et al.  MicroRNAs and drug-induced kidney injury. , 2016, Pharmacology & therapeutics.

[71]  C. Robinson-Cohen,et al.  Detection of Drug-Induced Acute Kidney Injury in Humans Using Urinary KIM-1, miR-21, -200c, and -423. , 2016, Toxicological sciences : an official journal of the Society of Toxicology.

[72]  J. Plana,et al.  The Utility of Point-of-Care Biomarkers to Detect Cardiotoxicity During Anthracycline Chemotherapy: A Feasibility Study. , 2016, Journal of cardiac failure.

[73]  M. Prostran,et al.  Evaluation of Novel Biomarkers of Acute Kidney Injury: The Possibilities and Limitations. , 2016, Current medicinal chemistry.

[74]  K. Jiao,et al.  Functions of miRNAs during Mammalian Heart Development , 2016, International journal of molecular sciences.

[75]  W. Wang,et al.  Correlation between circulating miR‐122 and prognosis of chronic HBV‐related liver failure , 2016, Journal of digestive diseases.

[76]  T. Olsson,et al.  Circulating miR-150 in CSF is a novel candidate biomarker for multiple sclerosis , 2016, Neurology: Neuroimmunology & Neuroinflammation.

[77]  G. Danan,et al.  Diagnosis and Management of Drug-Induced Liver Injury (DILI) in Patients with Pre-Existing Liver Disease , 2016, Drug Safety.

[78]  P. Ponikowski,et al.  Signature of circulating microRNAs in patients with acute heart failure , 2016, European journal of heart failure.

[79]  Andrea Acquaviva,et al.  isomiR-SEA: an RNA-Seq analysis tool for miRNAs/isomiRs expression level profiling and miRNA-mRNA interaction sites evaluation , 2016, BMC Bioinformatics.

[80]  Tingming Liang,et al.  miR-isomiRExp: a web-server for the analysis of expression of miRNA at the miRNA/isomiR levels , 2016, Scientific Reports.

[81]  A. Keller,et al.  Distribution of miRNA expression across human tissues , 2016, Nucleic acids research.

[82]  E. Høgdall,et al.  MicroRNA Expression in Formalin-fixed Paraffin-embedded Cancer Tissue: Identifying Reference MicroRNAs and Variability , 2015, BMC Cancer.

[83]  X. Calvet,et al.  Variability in microRNA recovery from plasma: Comparison of five commercial kits. , 2015, Analytical biochemistry.

[84]  Steven A. Bailey,et al.  Identification of Promising Urinary MicroRNA Biomarkers in Two Rat Models of Glomerular Injury. , 2015, Toxicological sciences : an official journal of the Society of Toxicology.

[85]  D. Cardinale,et al.  Detection and monitoring of cardiotoxicity by using biomarkers: Pros and cons: Remarks on the international colloquium on cardioncology. , 2015 .

[86]  J. Dear,et al.  Comprehensive microRNA profiling in acetaminophen toxicity identifies novel circulating biomarkers for human liver and kidney injury , 2015, Scientific Reports.

[87]  N. R. Shetty,et al.  Emerging Research in Computing, Information, Communication and Applications , 2015, Advances in Intelligent Systems and Computing.

[88]  R. Guddeti,et al.  Plasma Levels of microRNA-145 Are Associated with Severity of Coronary Artery Disease , 2015, PloS one.

[89]  I. Pogribny,et al.  The role for microRNAs in drug toxicity and in safety assessment , 2015, Expert opinion on drug metabolism & toxicology.

[90]  M. Madero,et al.  Biomarkers in chronic kidney disease, from kidney function to kidney damage. , 2015, World journal of nephrology.

[91]  S. Pfeffer,et al.  miR-122--a key factor and therapeutic target in liver disease. , 2015, Journal of hepatology.

[92]  T. Uehara,et al.  Plasma miR‐208 as a useful biomarker for drug‐induced cardiotoxicity in rats , 2015, Journal of applied toxicology : JAT.

[93]  Masahiko Kushida,et al.  Circulating miR-9* and miR-384-5p as Potential Indicators for Trimethyltin-induced Neurotoxicity , 2015, Toxicologic pathology.

[94]  T. Nawrot,et al.  MicroRNAs as Potential Signatures of Environmental Exposure or Effect: A Systematic Review , 2015, Environmental health perspectives.

[95]  Jan Ramon,et al.  A new ensemble coevolution system for detecting HIV-1 protein coevolution , 2015, Biology Direct.

[96]  G. Aktas,et al.  Does the kidney injury molecule-1 predict cisplatin-induced kidney injury in early stage? , 2015, Annals of clinical biochemistry.

[97]  Hailong Xie,et al.  U6 is not a suitable endogenous control for the quantification of circulating microRNAs. , 2014, Biochemical and biophysical research communications.

[98]  Myung-Gyu Kim,et al.  The incidence and risk factors of acute kidney injury after hepatobiliary surgery: a prospective observational study , 2014, BMC Nephrology.

[99]  A. Unami,et al.  Identification of urinary miRNA biomarkers for detecting cisplatin-induced proximal tubular injury in rats. , 2014, Toxicology.

[100]  I. Pogribny,et al.  Noncoding RNA response to xenobiotic exposure: an indicator of toxicity and carcinogenicity , 2014, Expert opinion on drug metabolism & toxicology.

[101]  M. Bushell,et al.  The complexity of miRNA-mediated repression , 2014, Cell Death and Differentiation.

[102]  T. Tuschl,et al.  Comparative RNA-sequencing analysis of myocardial and circulating small RNAs in human heart failure and their utility as biomarkers , 2014, Proceedings of the National Academy of Sciences.

[103]  D. Portilla,et al.  A basic science view of acute kidney injury biomarkers. , 2014, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[104]  S. Luo,et al.  Evaluation of quantitative miRNA expression platforms in the microRNA quality control (miRQC) study , 2014, Nature Methods.

[105]  Rounak Nassirpour,et al.  Identification of tubular injury microRNA biomarkers in urine: comparison of next-generation sequencing and qPCR-based profiling platforms , 2014, BMC Genomics.

[106]  Hongwei Wang,et al.  Expression of Serum Exosomal MicroRNA-21 in Human Hepatocellular Carcinoma , 2014, BioMed research international.

[107]  Luis Vaca,et al.  Point-of-care Diagnostic Tools to Detect Circulating MicroRNAS as Biomarkers of Disease , 2014, Sensors.

[108]  J. Dear,et al.  Early detection of paracetamol toxicity using circulating liver microRNA and markers of cell necrosis. , 2014, British journal of clinical pharmacology.

[109]  J. Dear,et al.  MicroRNAs as potential circulating biomarkers of drug-induced liver injury: key current and future issues for translation to humans , 2014, Expert review of clinical pharmacology.

[110]  N. Kosaka,et al.  Circulating MicroRNAs in Drug Safety Assessment for Hepatic and Cardiovascular Toxicity: The Latest Biomarker Frontier? , 2014, Molecular Diagnosis & Therapy.

[111]  W. Guan,et al.  Identification of suitable reference genes for hepatic microRNA quantitation , 2014, BMC Research Notes.

[112]  P. Watkins,et al.  Keratin‐18 and microRNA‐122 complement alanine aminotransferase as novel safety biomarkers for drug‐induced liver injury in two human cohorts , 2014, Liver international : official journal of the International Association for the Study of the Liver.

[113]  Yao Ruoquan,et al.  Correlation between plasma miR-122 expression and liver injury induced by hepatectomy , 2014, The Journal of international medical research.

[114]  Z. Ni,et al.  Diagnostic Value of Urinary Kidney Injury Molecule 1 for Acute Kidney Injury: A Meta-Analysis , 2014, PloS one.

[115]  X. Chen,et al.  A Combination of Let-7d, Let-7g and Let-7i Serves as a Stable Reference for Normalization of Serum microRNAs , 2013, PloS one.

[116]  R. Biondi,et al.  Differential Stability of Cell-Free Circulating microRNAs: Implications for Their Utilization as Biomarkers , 2013, PloS one.

[117]  Ri-sheng Que,et al.  Analysis of serum exosomal microRNAs and clinicopathologic features of patients with pancreatic adenocarcinoma , 2013, World Journal of Surgical Oncology.

[118]  T. Luedde,et al.  U6 is unsuitable for normalization of serum miRNA levels in patients with sepsis or liver fibrosis , 2013, Experimental & Molecular Medicine.

[119]  David M. Rocke,et al.  Stability of miRNA in human urine supports its biomarker potential. , 2013, Biomarkers in medicine.

[120]  Katherine E. Hill,et al.  Next-generation sequencing and microarray-based interrogation of microRNAs from formalin-fixed, paraffin-embedded tissue: preliminary assessment of cross-platform concordance. , 2013, Genomics.

[121]  E. Kroh,et al.  Plasma Processing Conditions Substantially Influence Circulating microRNA Biomarker Levels , 2013, PloS one.

[122]  Amir Lerman,et al.  Drug attrition during pre-clinical and clinical development: understanding and managing drug-induced cardiotoxicity. , 2013, Pharmacology & therapeutics.

[123]  S. Tang,et al.  Kidney injury molecule‐1: More than just an injury marker of tubular epithelial cells? , 2013, Journal of cellular physiology.

[124]  M. Nakajima,et al.  microRNAs as mediators of drug toxicity. , 2013, Annual review of pharmacology and toxicology.

[125]  S. Takagi,et al.  Biomarker panel of cardiac and skeletal muscle troponins, fatty acid binding protein 3 and myosin light chain 3 for the accurate diagnosis of cardiotoxicity and musculoskeletal toxicity in rats. , 2012, Toxicology.

[126]  R. Gold,et al.  Regulated microRNAs in the CSF of patients with multiple sclerosis , 2012, Neurology.

[127]  K. Kodys,et al.  Circulating microRNAs in exosomes indicate hepatocyte injury and inflammation in alcoholic, drug‐induced, and inflammatory liver diseases , 2012, Hepatology.

[128]  C. Bracken,et al.  IsomiRs--the overlooked repertoire in the dynamic microRNAome. , 2012, Trends in genetics : TIG.

[129]  Ronald P. Brown,et al.  Expression, circulation, and excretion profile of microRNA-21, -155, and -18a following acute kidney injury. , 2012, Toxicological sciences : an official journal of the Society of Toxicology.

[130]  Junjie Xiao,et al.  Circulating microRNAs: novel biomarkers for cardiovascular diseases , 2012, Journal of Molecular Medicine.

[131]  F. Staedtler,et al.  Perturbation of microRNAs in Rat Heart during Chronic Doxorubicin Treatment , 2012, PloS one.

[132]  David J. Galas,et al.  Comparing the MicroRNA Spectrum between Serum and Plasma , 2012, PloS one.

[133]  A. Moon,et al.  Drug-Induced Nephrotoxicity and Its Biomarkers , 2012, Biomolecules & therapeutics.

[134]  M. Tewari,et al.  MicroRNA profiling: approaches and considerations , 2012, Nature Reviews Genetics.

[135]  F. Azuaje,et al.  Use of circulating microRNAs to diagnose acute myocardial infarction. , 2012, Clinical chemistry.

[136]  K. Tsuneyama,et al.  Plasma MicroRNA Profiles in Rat Models of Hepatocellular Injury, Cholestasis, and Steatosis , 2012, PloS one.

[137]  Jonathan Moggs,et al.  Circulating microRNAs as potential markers of human drug‐induced liver injury , 2011, Hepatology.

[138]  Nicola J. Armstrong,et al.  Haemolysis during Sample Preparation Alters microRNA Content of Plasma , 2011, PloS one.

[139]  Alicia Algeciras-Schimnich,et al.  Analysis of circulating microRNA: preanalytical and analytical challenges. , 2011, Clinical chemistry.

[140]  J. Bakker,et al.  Neutrophil gelatinase-associated lipocalin at ICU admission predicts for acute kidney injury in adult patients. , 2011, American journal of respiratory and critical care medicine.

[141]  E. Kroh,et al.  Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma , 2011, Proceedings of the National Academy of Sciences.

[142]  K. Vickers,et al.  MicroRNAs are Transported in Plasma and Delivered to Recipient Cells by High-Density Lipoproteins , 2011, Nature Cell Biology.

[143]  Yue Wang,et al.  Plasma microRNA-122 as a biomarker for viral-, alcohol-, and chemical-related hepatic diseases. , 2010, Clinical chemistry.

[144]  Jessica A. Weber,et al.  The microRNA spectrum in 12 body fluids. , 2010, Clinical chemistry.

[145]  Stefanie Dimmeler,et al.  Circulating microRNAs: novel biomarkers for cardiovascular diseases? , 2010, European heart journal.

[146]  W. Huo,et al.  Kidney injury molecule-1 (KIM-1): a novel kidney-specific injury molecule playing potential double-edged functions in kidney injury. , 2010, Transplantation reviews.

[147]  Nicholas T. Ingolia,et al.  Mammalian microRNAs predominantly act to decrease target mRNA levels , 2010, Nature.

[148]  Takeshi Kimura,et al.  Acute doxorubicin cardiotoxicity is associated with miR-146a-induced inhibition of the neuregulin-ErbB pathway , 2010, Cardiovascular research.

[149]  A. Hammerle-Fickinger,et al.  mRNA and microRNA quality control for RT-qPCR analysis. , 2010, Methods.

[150]  Weida Tong,et al.  Biomarkers for drug-induced liver injury , 2010, Expert review of gastroenterology & hepatology.

[151]  Frank D Sistare,et al.  Plasma MicroRNAs as sensitive and specific biomarkers of tissue injury. , 2009, Clinical chemistry.

[152]  G. Hirokawa,et al.  Plasma miR-208 as a biomarker of myocardial injury. , 2009, Clinical chemistry.

[153]  L. Hood,et al.  Circulating microRNAs, potential biomarkers for drug-induced liver injury , 2009, Proceedings of the National Academy of Sciences.

[154]  Kourosh R. Ahmadi,et al.  Epidemiology and Genetic Epidemiology of the Liver Function Test Proteins , 2009, PloS one.

[155]  X. Chen,et al.  Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases , 2008, Cell Research.

[156]  Daniel B. Martin,et al.  Circulating microRNAs as stable blood-based markers for cancer detection , 2008, Proceedings of the National Academy of Sciences.

[157]  Anders Larsson,et al.  Use of multiple biomarkers to improve the prediction of death from cardiovascular causes. , 2008, The New England journal of medicine.

[158]  Stefano Volinia,et al.  MicroRNA expression profiling using microarrays , 2008, Nature Protocols.

[159]  P. O'Brien.  Cardiac troponin is the most effective translational safety biomarker for myocardial injury in cardiotoxicity. , 2008, Toxicology.

[160]  U. Malmqvist,et al.  Muscular exercise can cause highly pathological liver function tests in healthy men. , 2008, British journal of clinical pharmacology.

[161]  J. Lötvall,et al.  Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells , 2007, Nature Cell Biology.

[162]  T. Veenstra,et al.  Multiple biomarkers in molecular oncology , 2007, Expert review of molecular diagnostics.

[163]  Tyler Risom,et al.  Evolutionary conservation of microRNA regulatory circuits: an examination of microRNA gene complexity and conserved microRNA-target interactions through metazoan phylogeny. , 2007, DNA and cell biology.

[164]  T. Suter,et al.  Pathophysiology and diagnosis of cancer drug induced cardiomyopathy , 2007, Cardiovascular Toxicology.

[165]  Ligang Wu,et al.  MicroRNAs direct rapid deadenylation of mRNA. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[166]  N. Kaplowitz,et al.  Serum alanine aminotransferase in skeletal muscle diseases , 2005, Hepatology.

[167]  M. Pirmohamed,et al.  Adverse drug reactions as cause of admission to hospital: prospective analysis of 18 820 patients , 2004, BMJ : British Medical Journal.

[168]  F. Nevens,et al.  Plasma collected from heparinized blood is not suitable for HCV-RNA detection by conventional RT-PCR assay. , 1993, Journal of virological methods.

[169]  A. Hill.  Muscular Exercise , 1923, Nature.

[170]  Jens Allmer,et al.  Computational Prediction of Functional MicroRNA-mRNA Interactions. , 2019, Methods in molecular biology.

[171]  Sujit Kumar,et al.  A Review on Feature Selection Algorithms , 2019, Emerging Research in Computing, Information, Communication and Applications.

[172]  W. Bailey,et al.  Evaluation of the Relative Performance of Pancreas Specific microRNAs in Rat Plasma as Biomarkers of Pancreas Injury. , 2019, Toxicological sciences : an official journal of the Society of Toxicology.

[173]  Ralf Hofestädt,et al.  Visualization and Analysis of miRNAs Implicated in Amyotrophic Lateral Sclerosis Within Gene Regulatory Pathways , 2018, GMDS.

[174]  B. Rosenzweig,et al.  MicroRNA biomarkers of pancreatic injury in a canine model. , 2017, Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie.

[175]  M. Scherrer-Crosbie,et al.  The Role of Biomarkers: Troponins, BNP, MPO, and Other Biomarkers , 2017 .

[176]  K. Furu,et al.  Identification of Endogenous Controls for Use in miRNA Quantification in Human Cancer Cell Lines. , 2016, Cancer genomics & proteomics.

[177]  A. Tonevitsky,et al.  Circulating microRNAs , 2015, Biochemistry (Moscow).

[178]  P. Corey,et al.  Incidence of Adverse Drug Reactions in Hospitalized Patients , 2012 .

[179]  T. Blondal,et al.  Assessing sample and miRNA profile quality in serum and plasma or other biofluids. , 2013, Methods.

[180]  Sarah C. Emerson,et al.  Imperfect gold standards for kidney injury biomarker evaluation. , 2012, Journal of the American Society of Nephrology : JASN.

[181]  Xiaowei Xu,et al.  MicroRNA isolation from formalin-fixed, paraffin-embedded tissues. , 2011, Methods in molecular biology.

[182]  M. Froissart,et al.  Cystatin C: current position and future prospects , 2008, Clinical chemistry and laboratory medicine.

[183]  J. Vaupel,et al.  Evidence for a substantial genetic influence on biochemical liver function tests: results from a population-based Danish twin study. , 2001, Clinical chemistry.

[184]  J. Broussin,et al.  [Kidney injury]. , 1972, Bordeaux medical.