Adenoidal Hypertrophy and Allergic Rhinitis: Is There an Inverse Relationship?

Background Nasal obstruction is a very common symptom in children. The main causes are allergic rhinitis (AR) and adenoidal hypertrophy (AH); the possible correlation between AR and AH has been investigated by few studies, mainly conducted using radiographic craniometry. This study aimed at investigating this topic by nasal endoscopy. Methods There were 205 children (134 boys; mean age, 6.7 years age range, 4–12 years) studied. Clinical visit, nasal endoscopy, and skin-prick test were performed in all patients. Anterior nasal obstruction was graded using the Friedmann's classification. Adenoid size was graded using the Parikh's classification. Perception of symptoms by children was also assessed using the visual analog scale. Results Ninety-two children (44.9%) had complete nasal obstruction and 28 children (13.7%) had choanae invasion. There was a negative significant correlation (r = –0.41; p < 0.001) between nose obstruction severity and volume of adenoids. Decreased probability of greater adenoid volume was associated with increased severity of nose obstruction (odds ratio [OR] = 0.13) and in patients with allergy compared with nonallergic patients (OR = 0.31). Conclusion This real-life study shows that large adenoids may be associated with absence of allergy, whereas large turbinates may be associated with small adenoids.

[1]  R. Simon,et al.  The united allergic airway: Connections between allergic rhinitis, asthma, and chronic sinusitis , 2012, American journal of rhinology & allergy.

[2]  F. Occasi,et al.  The role of rhinomanometry after nasal decongestant test in the assessment of adenoid hypertrophy in children. , 2012, International journal of pediatric otorhinolaryngology.

[3]  M. Sadeghi-shabestari,et al.  Is there any correlation between allergy and adenotonsillar tissue hypertrophy? , 2012, International journal of pediatric otorhinolaryngology.

[4]  D. Hur,et al.  Expression of Chitinases in Hypertrophied Adenoids of Children , 2011, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[5]  S. Kivity,et al.  Expression of Th17 and Treg Lymphocyte Subsets in Hypertrophied Adenoids of Children and its Clinical Significance , 2011, Immunological investigations.

[6]  G. Ciprandi,et al.  Comparison between symptoms and endoscopy in children with nasal obstruction. , 2010, International journal of pediatric otorhinolaryngology.

[7]  J. Schroeder,et al.  Assessment of adenoid size: A comparison of lateral radiographic measurements, radiologist assessment, and nasal endoscopy. , 2010, International journal of pediatric otorhinolaryngology.

[8]  M. Bankaoglu,et al.  A retrospective analysis of adenoidal size in children with allergic rhinitis and nonallergic idiopathic rhinitis. , 2010, Asian Pacific journal of allergy and immunology.

[9]  B. Marple Allergic Rhinitis and Inflammatory Airway Disease: Interactions within the Unified Airspace , 2010, American journal of rhinology & allergy.

[10]  M. Nimwegen,et al.  United airways: circulating Th2 effector cells in an allergic rhinitis model are responsible for promoting lower airways inflammation , 2010, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[11]  G. Kraal,et al.  Different mechanisms regulate CD4(+) T cell independent induction of oral and nasal tolerance of CD8(+) T cells. , 2010, Immunobiology.

[12]  I. Yilmaz,et al.  Correlation between adenoid-nasopharynx ratio and endoscopic examination of adenoid hypertrophy: a blind, prospective clinical study. , 2009, International journal of pediatric otorhinolaryngology.

[13]  D. Caimmi,et al.  Role of adenoids and adenoiditis in children with allergy and otitis media , 2009, Current allergy and asthma reports.

[14]  Y. Ilan Oral tolerance: can we make it work? , 2009, Human immunology.

[15]  N. Fuleihan,et al.  How frequent is adenoid obstruction? Impact on the diagnostic approach , 2009, Pediatrics international : official journal of the Japan Pediatric Society.

[16]  L. Mayer,et al.  Suppression of Th1 and Th17, but not Th2, responses in a CD8+ T cell-mediated model of oral tolerance , 2009, Mucosal Immunology.

[17]  D. Broide Immunomodulation of allergic disease. , 2009, Annual review of medicine.

[18]  M. Martins,et al.  Oral tolerance attenuates airway inflammation and remodeling in a model of chronic pulmonary allergic inflammation , 2009, Respiratory Physiology & Neurobiology.

[19]  L. Ozluoglu,et al.  Correlation of diagnostic systems with adenoidal tissue volume: a blind prospective study. , 2008, International journal of pediatric otorhinolaryngology.

[20]  M. Dolhnikoff,et al.  Oral tolerance attenuates changes in in vitro lung tissue mechanics and extracellular matrix remodeling induced by chronic allergic inflammation in guinea pigs. , 2008, Journal of applied physiology.

[21]  A. Burks,et al.  Oral tolerance, food allergy, and immunotherapy: implications for future treatment. , 2008, The Journal of allergy and clinical immunology.

[22]  J. Krouse Allergic rhinitis--current pharmacotherapy. , 2008, Otolaryngologic clinics of North America.

[23]  M. Modrzyński,et al.  An analysis of the incidence of adenoid hypertrophy in allergic children. , 2007, International journal of pediatric otorhinolaryngology.

[24]  J. Corren The connection between allergic rhinitis and bronchial asthma , 2007, Current opinion in pulmonary medicine.

[25]  Paul W Major,et al.  Assessment of lateral cephalometric diagnosis of adenoid hypertrophy and posterior upper airway obstruction: a systematic review. , 2006, American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics.

[26]  T. Haahtela,et al.  Allergic rhinitis and asthma: inflammation in a one-airway condition , 2006, BMC pulmonary medicine.

[27]  James J. Lee,et al.  Validation of a new grading system for endoscopic examination of adenoid hypertrophy , 2006, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[28]  Y. Okayama,et al.  Comparison of human tonsillar mast cell localization and ultrastructural observations between IgE-mediated allergic and nonallergic donors. , 2006, Allergy and asthma proceedings.

[29]  J. Lundahl,et al.  IgE-positive plasma cells are present in adenoids of atopic children , 2006, Acta oto-laryngologica.

[30]  B. Lundin,et al.  Cytokines produced by T cells in adenoid surface secretion are mainly downregulatory or of Th1 type , 2006, Acta oto-laryngologica.

[31]  R. Taylor,et al.  Increased rates of ENT surgery among young children: Have clinical guidelines made a difference? , 2004, Journal of paediatrics and child health.

[32]  A. Hoes,et al.  Large international differences in (adeno)tonsillectomy rates. , 2004, Clinical otolaryngology and allied sciences.

[33]  G. Marseglia,et al.  Nasal endoscopy in asthmatic children: clinical role in the diagnosis of rhinosinusitis. , 2004, Rhinology.

[34]  C. Mccusker Use of mouse models of allergic rhinitis to study the upper and lower airway link , 2004, Current opinion in allergy and clinical immunology.

[35]  C. Bachert,et al.  Human β‐defensins and toll‐like receptors in the upper airway , 2003, Allergy.

[36]  A. Dirksen,et al.  The link between allergic rhinitis and allergic asthma: A prospective population‐based study. The Copenhagen Allergy Study , 2002, Allergy.

[37]  D. Jurkiewicz,et al.  Implication of immunological abnormalities after adenotonsillotomy. , 2002, International journal of pediatric otorhinolaryngology.

[38]  Shih-wen Huang,et al.  The risk of adenoid hypertrophy in children with allergic rhinitis. , 2001, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

[39]  G. Lack Pediatric allergic rhinitis and comorbid disorders. , 2001, The Journal of allergy and clinical immunology.

[40]  David Skoner,et al.  Allergic rhinitis: definition, epidemiology, pathophysiology, detection, and diagnosis. , 2001, The Journal of allergy and clinical immunology.

[41]  B. Bingham,et al.  Can nasal endoscopy be used to predict residual symptoms after adenoidectomy for nasal obstruction? , 2001, International journal of pediatric otorhinolaryngology.

[42]  B. Bingham,et al.  Endoscopy in the assessment of children with nasal obstruction , 2001, The Journal of Laryngology & Otology.

[43]  D. Caldarelli,et al.  A Safe, Alternative Technique for Inferior Turbinate Reduction , 1999, The Laryngoscope.

[44]  M. Grusby,et al.  Orally induced peripheral nonresponsiveness is maintained in the absence of functional Th1 or Th2 cells. , 1999, Journal of immunology.

[45]  N. Jones,et al.  Current concepts in the management of paediatric rhinosinusitis , 1999, The Journal of Laryngology & Otology.

[46]  A. Khoruts,et al.  Oral tolerance in disease , 1999, Gut.

[47]  J. Grossman,et al.  One airway, one disease. , 1997, Chest.

[48]  G. Gates Adenoidectomy for Otitis Media with Effusion , 1994, The Annals of otology, rhinology & laryngology. Supplement.

[49]  G. W. Bruyn,et al.  Clinical Anatomy of the Nose, Nasal Cavity and Paranasal Sinuses. Georg Thieme Verlag, Stuttgart, New York (1989), VIII+144 pp., 183 ill, DM 160,00, ISBN: 3 13 738401 X , 1991 .

[50]  E. Yumoto,et al.  [Influence of tonsillar hypertrophy to physical growth and diseases of the nose and ear in school-age children]. , 1991, Nihon Jibiinkoka Gakkai kaiho.

[51]  M. Kaliner,et al.  Allergy and the pharyngeal lymphoid tissues. , 1987, Otolaryngologic clinics of North America.

[52]  R. Roithmann,et al.  Sensitivity and specificity of nasal flexible fiberoptic endoscopy in the diagnosis of adenoid hypertrophy in children. , 2008, International journal of pediatric otorhinolaryngology.

[53]  Jeong-Whun Kim,et al.  Induction of airway remodeling of nasal mucosa by repetitive allergen challenge in a murine model of allergic rhinitis. , 2007, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

[54]  J. Bousquet,et al.  Allergic rhinitis: a disease remodeling the upper airways? , 2004, The Journal of allergy and clinical immunology.

[55]  Sang-Heon Cho,et al.  Preventive and therapeutic effects of oral tolerance in a murine model of asthma. , 2002, Immunobiology.

[56]  M. Jorissen,et al.  The Waldeyer's ring. , 2000, Acta oto-rhino-laryngologica Belgica.

[57]  G. Loughlin,et al.  High prevalence of allergic sensitization in children with habitual snoring and obstructive sleep apnea. , 1997, Chest.

[58]  V. Gerber [The importance of allergy in hypertrophy of the nasopharyngeal tonsil]. , 1966, Vestnik otorinolaringologii.