Breaking Cryo-EM Resolution Barriers to Facilitate Drug Discovery
暂无分享,去创建一个
Mindy I. Davis | A. Bartesaghi | S. Subramaniam | J. Milne | Soojay Banerjee | A. Merk | P. Rao | V. Falconieri | R. Pragani | M. Boxer | L. Earl | Mindy Davis
[1] Prashant Rao,et al. Using Cryo-EM to Map Small Ligands on Dynamic Metabolic Enzymes: Studies with Glutamate Dehydrogenase , 2016, Molecular Pharmacology.
[2] N. Ranson,et al. An introduction to sample preparation and imaging by cryo-electron microscopy for structural biology , 2016, Methods.
[3] W. Baumeister,et al. Cryo-EM single particle analysis with the Volta phase plate , 2016, eLife.
[4] A. Bartesaghi,et al. 2.3 Å resolution cryo-EM structure of human p97 and mechanism of allosteric inhibition , 2016, Science.
[5] Prashant Rao,et al. Cryo-EM Structures of the Magnesium Channel CorA Reveal Symmetry Break upon Gating , 2016, Cell.
[6] Georgios Skiniotis,et al. Single-particle cryo-electron microscopy of macromolecular complexes. , 2016, Microscopy.
[7] D. Boehringer,et al. Structures of the E. coli translating ribosome with SRP and its receptor and with the translocon , 2016, Nature Communications.
[8] D. Belnap. Electron Microscopy and Image Processing: Essential Tools for Structural Analysis of Macromolecules , 2015, Current protocols in protein science.
[9] Nicholas D. Adams,et al. New IDH1 mutant inhibitors for treatment of acute myeloid leukemia. , 2015, Nature chemical biology.
[10] E. Gouaux,et al. Glycine receptor mechanism elucidated by electron cryo-microscopy , 2015, Nature.
[11] Guanghui Yang,et al. Sampling the conformational space of the catalytic subunit of human γ-secretase , 2015, bioRxiv.
[12] B. Zheng,et al. Inhibition of Cancer-Associated Mutant Isocitrate Dehydrogenases by 2-Thiohydantoin Compounds. , 2015, Journal of medicinal chemistry.
[13] Sjors H. W. Scheres,et al. An atomic structure of human γ-secretase , 2015, Nature.
[14] A. Bartesaghi,et al. 2.2 Å resolution cryo-EM structure of β-galactosidase in complex with a cell-permeant inhibitor , 2015, Science.
[15] Yifan Cheng. Single-Particle Cryo-EM at Crystallographic Resolution , 2015, Cell.
[16] Marina V. Rodnina,et al. Structure of the E. coli ribosome–EF-Tu complex at <3 Å resolution by Cs-corrected cryo-EM , 2015, Nature.
[17] R. Stroud,et al. Subnanometre-resolution electron cryomicroscopy structure of a heterodimeric ABC exporter , 2014, Nature.
[18] Dietmar Hoffmann,et al. Selective Inhibition of Mutant Isocitrate Dehydrogenase 1 (IDH1) via Disruption of a Metal Binding Network by an Allosteric Small Molecule , 2014, The Journal of Biological Chemistry.
[19] BinQing Wei,et al. Identification of substituted 3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase. , 2014, Bioorganic & medicinal chemistry letters.
[20] Sriram Subramaniam,et al. Structure of β-galactosidase at 3.2-Å resolution obtained by cryo-electron microscopy , 2014, Proceedings of the National Academy of Sciences.
[21] Alan Brown,et al. Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine, large subunit , 2014 .
[22] R. Henderson,et al. Comparison of optimal performance at 300 keV of three direct electron detectors for use in low dose electron microscopy , 2014, Ultramicroscopy.
[23] S. Scheres,et al. Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine , 2014, eLife.
[24] Alan Brown,et al. Structure of the Yeast Mitochondrial Large Ribosomal Subunit , 2014, Science.
[25] Mindy I. Davis,et al. Biochemical, Cellular, and Biophysical Characterization of a Potent Inhibitor of Mutant Isocitrate Dehydrogenase IDH1* , 2014, The Journal of Biological Chemistry.
[26] M. Vettraino,et al. Inhibition of lactate dehydrogenase activity as an approach to cancer therapy. , 2014, Future medicinal chemistry.
[27] John P. Moore,et al. Cryo-EM Structure of a Fully Glycosylated Soluble Cleaved HIV-1 Envelope Trimer , 2013, Science.
[28] D. Julius,et al. Structure of the TRPV1 ion channel determined by electron cryo-microscopy , 2013, Nature.
[29] Jennifer B Dennison,et al. Quinoline 3-sulfonamides inhibit lactate dehydrogenase A and reverse aerobic glycolysis in cancer cells , 2013, Cancer & Metabolism.
[30] Dmitry Lyumkis,et al. Likelihood-based classification of cryo-EM images using FREALIGN. , 2013, Journal of structural biology.
[31] B. Prasad,et al. Crystallographic Investigation and Selective Inhibition of Mutant Isocitrate Dehydrogenase. , 2013, ACS medicinal chemistry letters.
[32] Li Li,et al. Lactate Dehydrogenase B Is Required for the Growth of KRAS-Dependent Lung Adenocarcinomas , 2012, Clinical Cancer Research.
[33] Xueming Li,et al. Fabs enable single particle cryoEM studies of small proteins. , 2012, Structure.
[34] Richard Henderson,et al. Tilt-Pair Analysis of Images from a Range of Different Specimens in Single-Particle Electron Cryomicroscopy , 2011, Journal of molecular biology.
[35] R. Glaeser,et al. Reaching the information limit in cryo-EM of biological macromolecules: experimental aspects. , 2011, Biophysical journal.
[36] Z. Zhou,et al. Hydrogen-bonding networks and RNA bases revealed by cryo electron microscopy suggest a triggering mechanism for calcium switches , 2011, Proceedings of the National Academy of Sciences.
[37] Adam Polkinghorne,et al. Chlamydia abortus YhbZ, a truncated Obg family GTPase, associates with the Escherichia coli large ribosomal subunit. , 2011, Microbial pathogenesis.
[38] Nikolaus Grigorieff,et al. Atomic model of an infectious rotavirus particle , 2010, The EMBO journal.
[39] Jianping Ding,et al. Molecular mechanisms of “off-on switch” of activities of human IDH1 by tumor-associated mutation R132H , 2010, Cell Research.
[40] Xing Zhang,et al. 3.3 Å Cryo-EM Structure of a Nonenveloped Virus Reveals a Priming Mechanism for Cell Entry , 2010, Cell.
[41] P. Emsley,et al. Features and development of Coot , 2010, Acta crystallographica. Section D, Biological crystallography.
[42] Randy J. Read,et al. Acta Crystallographica Section D Biological , 2003 .
[43] L. Liau,et al. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate , 2009, Nature.
[44] Z. Zhou,et al. 3.88 Å structure of cytoplasmic polyhedrosis virus by cryo-electron microscopy , 2008, Nature.
[45] David Belnap,et al. Electron Microscopy and Image Processing: An Essential Tool for Structural Analysis of Macromolecules , 2005, Current protocols in protein science.
[46] Jianping Ding,et al. Structures of Human Cytosolic NADP-dependent Isocitrate Dehydrogenase Reveal a Novel Self-regulatory Mechanism of Activity* , 2004, Journal of Biological Chemistry.
[47] R. Huddart,et al. Expression profile of genes from 12p in testicular germ cell tumors of adolescents and adults associated with i(12p) and amplification at 12p11.2–p12.1 , 2003, Oncogene.
[48] J. Frank,et al. A cryo-electron microscopic study of ribosome-bound termination factor RF2 , 2003, Nature.
[49] Gary Siuzdak,et al. The structure of apo human glutamate dehydrogenase details subunit communication and allostery. , 2002, Journal of molecular biology.
[50] M van Heel,et al. The Escherichia coli large ribosomal subunit at 7.5 A resolution. , 1999, Structure.
[51] R. Henderson. The potential and limitations of neutrons, electrons and X-rays for atomic resolution microscopy of unstained biological molecules , 1995, Quarterly Reviews of Biophysics.
[52] R. Henderson,et al. Model for the structure of bacteriorhodopsin based on high-resolution electron cryo-microscopy. , 1990, Journal of molecular biology.