Defective triglyceride removal in lipemia associated with peritoneal dialysis and haemodialysis.

Plasma lipids were measured in 78 uremic patients receiving either chronic peritoneal dialysis or haemodialysis. Type IV hyperlipemia was found in 60% of patients. The lipid level was not influenced by dietary habits or patient's age. Patients on chronic peritoneal dialysis had a significantly higher and more sustained hyperlipemia than the patients on haemodialysis. Triglyceride turnover studies showed that all patients, regardless of the type of dialysis or lipid level, had impaired triglyceride removal as the cause of this lipemia. This defect in triglyceride metabolism was only partially corrected by increasing the efficiency of the dialysis.

[1]  E. Nikkilä,et al.  Polymorphism of plasma triglyceride kinetics in normal human adult subjects. , 2009, Acta medica Scandinavica.

[2]  T. Murase,et al.  Triglyceride turnover: a comparison of simultaneous determinations using the radioglyceride and the lipolytic rate procedures. , 1975, Federation proceedings.

[3]  D. Cattran,et al.  Inhibition of lipoprotein lipase by uremic plasma, a possible cause of hypertriglyceridemia. , 1975, Metabolism: clinical and experimental.

[4]  L. Carlson,et al.  Quantitative and qualitative serum lipoprotein analysis. Part 1. Studies in healthy men and women. , 1975, Atherosclerosis.

[5]  B. Scribner,et al.  Accelerated atherosclerosis in prolonged maintenance hemodialysis. , 1974, The New England journal of medicine.

[6]  G. Reaven,et al.  Sex Difference in the Kinetics of Triglyceride Metabolism in Normal and Hypertriglyceridaemic Human Subjects , 1974, European journal of clinical investigation.

[7]  M. Pendray,et al.  Advantages of peritoneal dialysis in chronic renal failure. , 1973, JAMA.

[8]  J. Sheldon,et al.  Changes in glucose tolerance, insulin, serum lipids and lipoproteins in patients with renal failure on intermittent haemodialysis , 1973, Postgraduate medical journal.

[9]  G. Reaven,et al.  Prevalence of Plasma Lipoprotein Abnormalities in a Free‐Living Population of the Central Valley, California , 1972, Circulation.

[10]  H. Tenckhoff,et al.  A SIMPLIFIED AUTOMATIC PERITONEAL DIALYSIS SYSTEM , 1972, Transactions - American Society for Artificial Internal Organs.

[11]  F. A. Bryan,et al.  National registry of long-term dialysis patients. , 1971, JAMA.

[12]  E. Nikkilä,et al.  Plasma Triglyceride Metabolism in the Adult Nephrotic Syndrome , 1971, European journal of clinical investigation.

[13]  J. Bagdade.  Uremic lipemia. An unrecognized abnormality in triglyceride production and removal. , 1970, Archives of internal medicine.

[14]  D. Porte,et al.  The effect of heparin infusion on plasma triglyceride in vivo and in vitro with a method for calculating triglyceride turnover. , 1969, The Journal of laboratory and clinical medicine.

[15]  J. Bagdade,et al.  Hypertriglyceridemia. A metabolic consequence of chronic renal failure. , 1968, The New England journal of medicine.

[16]  P. Nestel,et al.  Studies on the turnover of triglyceride and esterified cholesterol in subjects with the nephrotic syndrome. , 1968, The Journal of clinical investigation.

[17]  E. Friedman,et al.  Plasma lipid studies of uremic patients during hemodialysis. , 1968, The American journal of clinical nutrition.

[18]  R. Lees,et al.  Fat transport in lipoproteins--an integrated approach to mechanisms and disorders. , 1967, The New England journal of medicine.

[19]  G. Reaven,et al.  Kinetics of triglyceride turnover of very low density lipoproteins of human plasma. , 1965, The Journal of clinical investigation.

[20]  P. Jc,et al.  Kinetics of peritoneal dialysis , 1965 .

[21]  Hatch Ft,et al.  Sharper separation of lipoprotein species by paper electrophoresis in albumin-containing buffer. , 1963 .

[22]  M. E. Brown.  Ultra-micro Sugar Determinations Using 2,9-dimethyl-1,10-phenanthroline Hydrochloride (Neocuproine) , 1961, Diabetes.

[23]  D. Porte,et al.  Uremic lipemia: an unrecognized abnormality in triglyceride synthesis and removal. , 1968, Transactions of the Association of American Physicians.

[24]  G. Reaven,et al.  VALIDATION OF AN INCOMPLETELY COUPLED TWO-COMPARTMENT NONRECYCLING CATENARY MODEL FOR TURNOVER OF LIVER AND PLASMA TRIGLYCERIDE IN MAN. , 1965, Journal of lipid research.

[25]  D. Bittner.  The cupric-phenoanthroline chelate in the determination of monosaccharides in whole blood , 1963 .