Modeling hypoxia-related inflammation scenarios.

[1]  I. Baranowska-Bosiacka,et al.  Chronic and Cycling Hypoxia: Drivers of Cancer Chronic Inflammation through HIF-1 and NF-κB Activation: A Review of the Molecular Mechanisms , 2021, International journal of molecular sciences.

[2]  M. Ohh,et al.  HIF-1α hydroxyprolines modulate oxygen-dependent protein stability via single VHL interface with comparable effect on ubiquitination rate. , 2021, Journal of molecular biology.

[3]  S. Vetter,et al.  Hypoxia and the Receptor for Advanced Glycation End Products (RAGE) Signaling in Cancer , 2021, International journal of molecular sciences.

[4]  Joel s. Brown,et al.  Cycling hypoxia selects for constitutive HIF stabilization , 2020, Scientific Reports.

[5]  M. Neuss-Radu,et al.  A Mathematical Model of HIF-1 Regulated Cellular Energy Metabolism , 2020, Vietnam Journal of Mathematics.

[6]  L. Ricci-Vitiani,et al.  Hypoxia, Inflammation and Necrosis as Determinants of Glioblastoma Cancer Stem Cells Progression , 2020, International journal of molecular sciences.

[7]  A. Coulibaly,et al.  Interleukin-15 Signaling in HIF-1α Regulation in Natural Killer Cells, Insights Through Mathematical Models , 2019, Front. Immunol..

[8]  F. Greten,et al.  Inflammation and Cancer: Triggers, Mechanisms, and Consequences. , 2019, Immunity.

[9]  G. Semenza.  Pharmacologic Targeting of Hypoxia-Inducible Factors. , 2019, Annual review of pharmacology and toxicology.

[10]  S. Walmsley,et al.  Inflammation and Hypoxia: HIF and PHD Isoform Selectivity. , 2019, Trends in molecular medicine.

[11]  L. Dubois,et al.  Prognostic Role of Hypoxia-Inducible Factor-2α Tumor Cell Expression in Cancer Patients: A Meta-Analysis , 2018, Front. Oncol..

[12]  Bo Zhang,et al.  Mathematical modelling of interacting mechanisms for hypoxia mediated cell cycle commitment for mesenchymal stromal cells , 2018, BMC Systems Biology.

[13]  Xueying Sun,et al.  Development of Inhibitors Targeting Hypoxia-Inducible Factor 1 and 2 for Cancer Therapy , 2017, Yonsei medical journal.

[14]  B. Kholodenko,et al.  A dynamic model of the hypoxia-inducible factor 1a (HIF-1a) network , 2015, Journal of Cell Science.

[15]  V. Sée,et al.  Modeling the dynamics of hypoxia inducible factor-1α (HIF-1α) within single cells and 3D cell culture systems. , 2014, Mathematical biosciences.

[16]  G. Semenza,et al.  A genetic mechanism for Tibetan high-altitude adaptation , 2014, Nature Genetics.

[17]  Yan Shi,et al.  HIF-1 Alpha Overexpression Correlates with Poor Overall Survival and Disease-Free Survival in Gastric Cancer Patients Post-Gastrectomy , 2014, PloS one.

[18]  A. Stéphanou,et al.  A mathematical model of HiF-1α-mediated response to hypoxia on the G1/S transition. , 2014, Mathematical biosciences.

[19]  S. McKeown,et al.  Defining normoxia, physoxia and hypoxia in tumours-implications for treatment response. , 2014, The British journal of radiology.

[20]  V. Sée,et al.  Tight Control of Hypoxia-inducible Factor-α Transient Dynamics Is Essential for Cell Survival in Hypoxia , 2014, The Journal of Biological Chemistry.

[21]  M. J. Knapp,et al.  Substrate preference of the HIF-prolyl hydroxylase-2 (PHD2) and substrate-induced conformational change. , 2013, Journal of inorganic biochemistry.

[22]  M. Russo,et al.  Modulators of HIF1α and NFkB in Cancer Treatment: Is it a Rational Approach for Controlling Malignant Progression? , 2012, Front. Pharmacol..

[23]  G. Powis,et al.  Passing the baton: the HIF switch. , 2012, Trends in biochemical sciences.

[24]  G. Kristiansen,et al.  Non-canonical HIF-2α function drives autonomous breast cancer cell growth via an AREG–EGFR/ErbB4 autocrine loop , 2012, Oncogene.

[25]  G. Semenza,et al.  Hypoxia-Inducible Factors in Physiology and Medicine , 2012, Cell.

[26]  M. Russo,et al.  Hypoxia-increased RAGE and P2X7R expression regulates tumor cell invasion through phosphorylation of Erk1/2 and Akt and nuclear translocation of NF-{kappa}B. , 2011, Carcinogenesis.

[27]  Peter Carmeliet,et al.  Hypoxia and inflammation. , 2011, The New England journal of medicine.

[28]  Timothy K Lee,et al.  Single-cell NF-κB dynamics reveal digital activation and analogue information processing , 2010, Nature.

[29]  M. Brady,et al.  Tumour glycolysis: the many faces of HIF. , 2008, Journal of theoretical biology.

[30]  W. Kaelin,et al.  Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. , 2008, Molecular cell.

[31]  S. Vannucci,et al.  Hypoxia-inducible Factor-1 Mediates Neuronal Expression of the Receptor for Advanced Glycation End Products following Hypoxia/Ischemia* , 2007, Journal of Biological Chemistry.

[32]  Aleksander S. Popel,et al.  Three autocrine feedback loops determine HIF1α expression in chronic hypoxia , 2007 .

[33]  Rahul Simha,et al.  Pathway Switching Explains the Sharp Response Characteristic of Hypoxia Response Network , 2007, PLoS Comput. Biol..

[34]  Å. Borg,et al.  Recruitment of HIF-1alpha and HIF-2alpha to common target genes is differentially regulated in neuroblastoma: HIF-2alpha promotes an aggressive phenotype. , 2006, Cancer cell.

[35]  K. Kivirikko,et al.  The Length of Peptide Substrates Has a Marked Effect on Hydroxylation by the Hypoxia-inducible Factor Prolyl 4-Hydroxylases* , 2006, Journal of Biological Chemistry.

[36]  Roland H Wenger,et al.  Increased Prolyl 4-Hydroxylase Domain Proteins Compensate for Decreased Oxygen Levels , 2006, Journal of Biological Chemistry.

[37]  P. Ratcliffe,et al.  Determination and comparison of specific activity of the HIF‐prolyl hydroxylases , 2004, FEBS letters.

[38]  A. Harris,et al.  Differential Function of the Prolyl Hydroxylases PHD1, PHD2, and PHD3 in the Regulation of Hypoxia-inducible Factor* , 2004, Journal of Biological Chemistry.

[39]  G. Semenza,et al.  Hydroxylation of HIF-1: oxygen sensing at the molecular level. , 2004, Physiology.

[40]  K. Kivirikko,et al.  Characterization of the Human Prolyl 4-Hydroxylases That Modify the Hypoxia-inducible Factor* , 2003, Journal of Biological Chemistry.

[41]  J. Pouysségur,et al.  HIF prolyl‐hydroxylase 2 is the key oxygen sensor setting low steady‐state levels of HIF‐1α in normoxia , 2003, The EMBO journal.

[42]  W. Jelkmann,et al.  Intracellular localisation of human HIF-1α hydroxylases: implications for oxygen sensing , 2003, Journal of Cell Science.

[43]  G. Semenza,et al.  Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension. , 1996, The American journal of physiology.

[44]  P. Ratcliffe,et al.  Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay. , 2007, The Biochemical journal.