Methylation patterns and K-ras mutations in tumor and paired serum of resected non-small-cell lung cancer patients.

[1]  W. Leung,et al.  Detection of gene promoter hypermethylation in the tumor and serum of patients with gastric carcinoma. , 2002, Clinical cancer research : an official journal of the American Association for Cancer Research.

[2]  Michael J. Terry,et al.  HOX gene clusters are hotspots of de novo methylation in CpG islands of human lung adenocarcinomas , 2002, Oncogene.

[3]  G. Pfeifer,et al.  The CpG island of the novel tumor suppressor gene RASSF1A is intensely methylated in primary small cell lung carcinomas , 2001, Oncogene.

[4]  W. Schlegel,et al.  Discordance between K-ras mutations in bone marrow micrometastases and the primary tumor in colorectal cancer. , 2001, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[5]  J. Minna,et al.  Epigenetic inactivation of RASSF1A in lung and breast cancers and malignant phenotype suppression. , 2001, Journal of the National Cancer Institute.

[6]  J. Herman,et al.  A gene hypermethylation profile of human cancer. , 2001, Cancer research.

[7]  G. Yang,et al.  Hypermethylation of the cpG island of Ras association domain family 1A (RASSF1A), a putative tumor suppressor gene from the 3p21.3 locus, occurs in a large percentage of human breast cancers. , 2001, Cancer research.

[8]  E. Mark,et al.  Promoter methylation of DAP-kinase: association with advanced stage in non-small cell lung cancer , 2001, Oncogene.

[9]  J. Minna,et al.  Aberrant promoter methylation of multiple genes in non-small cell lung cancers. , 2001, Cancer research.

[10]  S. Warren,et al.  TMS1, a novel proapoptotic caspase recruitment domain protein, is a target of methylation-induced gene silencing in human breast cancers. , 2000, Cancer research.

[11]  F. Khuri,et al.  Hypermethylation of the death-associated protein (DAP) kinase promoter and aggressiveness in stage I non-small-cell lung cancer. , 2000, Journal of the National Cancer Institute.

[12]  Chun Xing Li,et al.  Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3 , 2000, Nature Genetics.

[13]  F. A. Benko,et al.  Somatic mutation screening: identification of individuals harboring K-ras mutations with the use of plasma DNA. , 2000, Journal of the National Cancer Institute.

[14]  E. Mark,et al.  Implications and prognostic value of K-ras mutation for early-stage lung cancer in women. , 1999, Journal of the National Cancer Institute.

[15]  M. Higashiyama,et al.  A novel molecular staging protocol for non-small cell lung cancer , 1999, Oncogene.

[16]  J. Herman,et al.  Detection of aberrant promoter hypermethylation of tumor suppressor genes in serum DNA from non-small cell lung cancer patients. , 1999, Cancer research.

[17]  Peter A. Jones,et al.  DAP-kinase loss of expression in various carcinoma and B-cell lymphoma cell lines: possible implications for role as tumor suppressor gene , 1997, Oncogene.

[18]  C. Mountain,et al.  Revisions in the International System for Staging Lung Cancer. , 1997, Chest.

[19]  J. Herman,et al.  Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[20]  A. Ariza,et al.  Molecular staging of non-small cell lung cancer according to K-ras genotypes. , 1996, Clinical cancer research : an official journal of the American Association for Cancer Research.

[21]  J. Herman,et al.  5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers , 1995, Nature Medicine.

[22]  J. Dr,et al.  A highly sensitive assay for mutant ras genes and its application to the study of presentation and relapse genotypes in acute leukemia. , 1994 .

[23]  J. Mate,et al.  Prognostic impact of mutated K-ras gene in surgically resected non-small cell lung cancer patients. , 1993, Oncogene.

[24]  S. Steinberg,et al.  ras gene mutations in non-small cell lung cancers are associated with shortened survival irrespective of treatment intent. , 1991, Cancer research.

[25]  S. Rodenhuis,et al.  Relationship between K-ras oncogene activation and smoking in adenocarcinoma of the human lung. , 1991, Journal of the National Cancer Institute.

[26]  C. Marshall,et al.  Multiple K-ras codon 12 mutations in cholangiocarcinomas demonstrated with a sensitive polymerase chain reaction technique. , 1991, Cancer research.