Discrimination between benign and malignant prostate tissue using chromatin texture analysis in 3‐D by confocal laser scanning microscopy

Analysis of chromatin texture may improve both the diagnosis and the assessment of the prognosis of prostate cancer. Confocal laser scanning microscopy (CLSM) allows performing measurements in nuclei reconstructed in 3‐D. The aim of this study was to evaluate the clinical usefulness of 3‐D texture analysis of prostate tissue.

[1]  P H Bartels,et al.  Computer‐generated diagnosis and image analysis. An Overview , 1992, Cancer.

[2]  B Palcic,et al.  Nuclear texture measurements in image cytometry. , 1995, Pathologica.

[3]  Bidyut Baran Chaudhuri,et al.  Texture Segmentation Using Fractal Dimension , 1995, IEEE Trans. Pattern Anal. Mach. Intell..

[4]  P. V. van Diest,et al.  THREE‐DIMENSIONAL CONFOCAL LASER SCANNING DNA PLOIDY CYTOMETRY IN THICK HISTOLOGICAL SECTIONS , 1996, The Journal of pathology.

[5]  J. Peterse,et al.  Prognostic value of DNA ploidy using flow cytometry in 1301 breast cancer patients: results of the prospective Multicenter Morphometric Mammary Carcinoma Project. , 1997, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.

[6]  K. Takata,et al.  DNA Staining for Fluorescence and Laser Confocal Microscopy , 1997, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[7]  P H Bartels,et al.  Nuclear chromatin texture in prostatic lesions. I. PIN and adenocarcinoma. , 1998, Analytical and quantitative cytology and histology.

[8]  P H Bartels,et al.  Chromatin texture signatures in nuclei from prostate lesions. , 1998, Analytical and quantitative cytology and histology.

[9]  P H Bartels,et al.  Nuclear chromatin texture in prostatic lesions. II. PIN and malignancy associated changes. , 1998, Analytical and quantitative cytology and histology.

[10]  S. Hell,et al.  4Pi-confocal imaging in fixed biological specimens. , 1998, Biophysical journal.

[11]  Gregor Mikuz,et al.  Nuclear chromatin texture analysis of nonmalignant tissue can detect adjacent prostatic adenocarcinoma , 1999 .

[12]  Jan P. A. Baak,et al.  Malignancy-Associated Changes in Breast Tissue Detected by Image Cytometry , 2000, Analytical cellular pathology : the journal of the European Society for Analytical Cellular Pathology.

[13]  R W Veltri,et al.  Quantitative nuclear grade (QNG): A new image analysis‐based biomarker of clinically relevant nuclear structure alterations , 2000, Journal of cellular biochemistry. Supplement.

[14]  J. Conchello,et al.  Artefacts in restored images due to intensity loss in three‐dimensional fluorescence microscopy , 2001, Journal of microscopy.

[15]  G. Haroske,et al.  Fourth Updated ESACP Consensus Report on Diagnostic DNA Image Cytometry , 2001, Analytical cellular pathology : the journal of the European Society for Analytical Cellular Pathology.

[16]  P. V. van Diest,et al.  Confocal DNA cytometry: a contour-based segmentation algorithm for automated three-dimensional image segmentation. , 2002, Cytometry.

[17]  P. Verhagen,et al.  Prognostic factors in localised prostate cancer with emphasis on the application of molecular techniques. , 2002, European urology.

[18]  Daniele Zink,et al.  Nuclear structure in cancer cells , 2004, Nature Reviews Cancer.

[19]  P. V. van Diest,et al.  Confocal 3D DNA Cytometry: Assessment of Required Coefficient of Variation by Computer Simulation , 2004, Cellular oncology : the official journal of the International Society for Cellular Oncology.

[20]  Jonathan I. Epstein,et al.  Ability to Predict Metastasis Based On Pathology Findings and Alterations in Nuclear Structure Of Normal-Appearing and Cancer Peripheral Zone Epithelium in the Prostate , 2004, Clinical Cancer Research.

[21]  André Huisman,et al.  Development of 3D Chromatin Texture Analysis Using Confocal Laser Scanning Microscopy , 2005, Cellular oncology : the official journal of the International Society for Cellular Oncology.

[22]  A. Huisman,et al.  Implementation of Accurate and Fast DNA Cytometry by Confocal Microscopy in 3D , 2005, Cellular oncology : the official journal of the International Society for Cellular Oncology.