Wireless, battery-free, flexible, miniaturized dosimeters monitor exposure to solar radiation and to light for phototherapy

Wireless, battery-free, flexible dosimeters measure personalized exposure to electromagnetic radiation outdoors and in clinical environments. Safer sun exposure Almost all skin cancers are caused by excessive ultraviolet (UV) irradiation from the sun. Sunscreens can reflect or absorb UV light to protect skin from damage but do not provide a measure of UV exposure. Heo et al. developed flexible, wireless, battery-free dosimeters to monitor light exposure. Body-worn sensors on human participants recorded UVA exposure during recreational outdoor activities, including swimming. Sensors could be fabricated in different shapes and sizes, could capture UVA and UVB exposure for clinical phototherapy, and could measure blue light exposure on infants with jaundice during bilirubin phototherapy. This wireless sensor platform technology enables high precision tracking of instantaneous and cumulative light exposure. Exposure to electromagnetic radiation can have a profound impact on human health. Ultraviolet (UV) radiation from the sun causes skin cancer. Blue light affects the body’s circadian melatonin rhythm. At the same time, electromagnetic radiation in controlled quantities has beneficial use. UV light treats various inflammatory skin conditions, and blue light phototherapy is the standard of care for neonatal jaundice. Although quantitative measurements of exposure in these contexts are important, current systems have limited applicability outside of laboratories because of an unfavorable set of factors in bulk, weight, cost, and accuracy. We present optical metrology approaches, optoelectronic designs, and wireless modes of operation that serve as the basis for miniature, low-cost, and battery-free devices for precise dosimetry at multiple wavelengths. These platforms use a system on a chip with near-field communication functionality, a radio frequency antenna, photodiodes, supercapacitors, and a transistor to exploit a continuous accumulation mechanism for measurement. Experimental and computational studies of the individual components, the collective systems, and the performance parameters highlight the operating principles and design considerations. Evaluations on human participants monitored solar UV exposure during outdoor activities, captured instantaneous and cumulative exposure during blue light phototherapy in neonatal intensive care units, and tracked light illumination for seasonal affective disorder phototherapy. Versatile applications of this dosimetry platform provide means for consumers and medical providers to modulate light exposure across the electromagnetic spectrum in a way that can both reduce risks in the context of excessive exposure and optimize benefits in the context of phototherapy.

[1]  Sean A. Munson,et al.  Reconsidering the device in the drawer: lapses as a design opportunity in personal informatics , 2016, UbiComp.

[2]  Charles A Czeisler,et al.  High sensitivity of the human circadian melatonin rhythm to resetting by short wavelength light. , 2003, The Journal of clinical endocrinology and metabolism.

[3]  D. Lugg,et al.  The measurement of solar ultraviolet radiation. , 1998, Mutation research.

[4]  Sang Youn Han,et al.  Flexible Near-Field Wireless Optoelectronics as Subdermal Implants for Broad Applications in Optogenetics , 2017, Neuron.

[5]  Jung Woo Lee,et al.  Battery-free, stretchable optoelectronic systems for wireless optical characterization of the skin , 2016, Science Advances.

[6]  Shayak Banerjee,et al.  A comparative study of wearable ultraviolet radiometers , 2017, 2017 IEEE Life Sciences Conference (LSC).

[7]  H. Ananthaswamy,et al.  The basal layer in human squamous tumors harbors more UVA than UVB fingerprint mutations: a role for UVA in human skin carcinogenesis. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[8]  S Hansen,et al.  Skin cancer in kidney and heart transplant recipients and different long-term immunosuppressive therapy regimens. , 1999, Journal of the American Academy of Dermatology.

[9]  Brett M Coldiron,et al.  No end in sight: the skin cancer epidemic continues. , 2011, Seminars in cutaneous medicine and surgery.

[10]  R. Hamer,et al.  The efficacy of light therapy in the treatment of mood disorders: a review and meta-analysis of the evidence. , 2005, The American journal of psychiatry.

[11]  Mohammad Athar,et al.  The other end of the rainbow: infrared and skin. , 2010, The Journal of investigative dermatology.

[12]  Sean A. Munson,et al.  Beyond Abandonment to Next Steps: Understanding and Designing for Life after Personal Informatics Tool Use , 2016, CHI.

[13]  Benjamin D. Smith,et al.  Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States. , 2014, Cancer research.

[14]  T R Sisson,et al.  Phototherapy of jaundice in the newborn infant. II. Effect of various light intensities. , 1972, The Journal of pediatrics.

[15]  Hensin Tsao,et al.  A population‐based analysis of risk factors for a second primary cutaneous melanoma among melanoma survivors , 2003, Cancer.

[16]  Subcommittee on Hyperbilirubinemia Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation. , 2004, Pediatrics.

[17]  Karalee Poschman,et al.  Cost of Hospitalization for Preterm and Low Birth Weight Infants in the United States , 2007, Pediatrics.

[18]  J. Parrish,et al.  The interaction of UVA and UVB in the production of threshold erythema. , 1982, The Journal of investigative dermatology.

[19]  B. N. Wenny,et al.  Aerosol optical depth measurements and their impact on surface levels of ultraviolet‐B radiation , 2001 .

[20]  Jeonghyun Kim,et al.  Materials and Device Designs for an Epidermal UV Colorimetric Dosimeter with Near Field Communication Capabilities , 2017 .

[21]  Alfio V Parisi,et al.  Human UVA exposures estimated from ambient UVA measurements , 2003, Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology.

[22]  John A Rogers,et al.  Miniaturized, light-adaptive, wireless dosimeters autonomously monitor exposure to electromagnetic radiation , 2019, Science Advances.

[23]  Jung Woo Lee,et al.  Epidermal electronics with advanced capabilities in near-field communication. , 2015, Small.

[24]  F. Scheer,et al.  Short-wavelength sensitivity for the direct effects of light on alertness, vigilance, and the waking electroencephalogram in humans. , 2006, Sleep.

[25]  N Kollias,et al.  Synergistic effects of long‐wavelength ultraviolet A1 and visible light on pigmentation and erythema , 2018, The British journal of dermatology.

[26]  K.,et al.  Prevalence and costs of skin cancer treatment in the U.S., 2002-2006 and 2007-2011. , 2015, American journal of preventive medicine.

[27]  John A Rogers,et al.  Miniaturized Battery‐Free Wireless Systems for Wearable Pulse Oximetry , 2017, Advanced functional materials.

[28]  A. Jemal,et al.  Cancer treatment and survivorship statistics, 2012 , 2012, CA: a cancer journal for clinicians.

[29]  G. Brainard,et al.  Breast cancer and circadian disruption from electric lighting in the modern world , 2014, CA: a cancer journal for clinicians.

[30]  Maxim E. Darvin,et al.  Blue-Violet Light Irradiation Dose Dependently Decreases Carotenoids in Human Skin, Which Indicates the Generation of Free Radicals , 2015, Oxidative medicine and cellular longevity.

[31]  Christian Koehler,et al.  Why we use and abandon smart devices , 2015, UbiComp.

[32]  Walter W. Hauck,et al.  Light Therapy for Seasonal Affective Disorder with Blue Narrow-Band Light-Emitting Diodes (LEDs) , 2006, Biological Psychiatry.