Influence of Nanoparticles on the Brain‐to‐serum Distribution and the Metabolism of Valproic Acid in Mice

The suitability of nanoparticles as a drug‐carrier system for the antiepileptic valproic acid has been studied in mice. The aim of the study was to increase the brain‐to‐serum ratio of the drug to reduce dose‐related side effects in the periphery. The influence of nanoparticles on the metabolism of valproic acid was also investigated.

[1]  J. Kreuter,et al.  Modification of the body distribution of poly(methyl methacrylate) nanoparticles in rats by coating with surfactants , 1990 .

[2]  H. Muro,et al.  Metabolite profiles in patients on high-dose valproate monotherapy , 1996, Epilepsy Research.

[3]  G. Ojemann,et al.  Distribution of Unsaturated Metabolites of Valproate in Human and Rat Brain‐Pharmacologic Relevance? , 1995, Epilepsia.

[4]  Bernhard A. Sabel,et al.  Nanoparticles, a drug carrier system to pass the blood-brain barrier, permit central analgesic effects of i.v. dalargin injections , 1996, Brain Research.

[5]  H. Nau,et al.  Binding of a valproate metabolite to the trifunctional protein of fatty acid oxidation , 1996, FEBS letters.

[6]  R. Allen.  Valproic acid toxicity. , 1985, American journal of diseases of children.

[7]  D. Shen,et al.  Uptake of valproic acid into rat brain is mediated by a medium-chain fatty acid transporter. , 1996, The Journal of pharmacology and experimental therapeutics.

[8]  G. Granneman,et al.  Aspects of the metabolism of valproic acid. , 1984, Xenobiotica; the fate of foreign compounds in biological systems.

[9]  W. Löscher,et al.  Kinetics of Penetration of Common Antiepileptic Drugs into Cerebrospinal Fluid , 1984, Epilepsia.

[10]  M. Jurima‐Romet,et al.  Cytotoxicity of unsaturated metabolites of valproic acid and protection by vitamins C and E in glutathione-depleted rat hepatocytes. , 1996, Toxicology.

[11]  J. Darius.  On-column gas chromatographic-mass spectrometric assay for metabolic profiling of valproate in brain tissue and serum. , 1996, Journal of chromatography. B, Biomedical applications.

[12]  B. Sabel,et al.  Nanoparticle technology for delivery of drugs across the blood-brain barrier. , 1998, Journal of pharmaceutical sciences.

[13]  H. Nau,et al.  Anticonvulsant and neurotoxic activities of twelve analogues of valproic acid. , 1993, Journal of pharmaceutical sciences.