Age-Related Changes in DNA Methylation Associated with Shifting Th1/Th2 Balance

[1]  G. Pfeifer,et al.  Aging and DNA methylation , 2015, BMC Biology.

[2]  S. Horvath DNA methylation age of human tissues and cell types , 2013, Genome Biology.

[3]  R. Flavell,et al.  Hypersensitive site 6 of the Th2 locus control region is essential for Th2 cytokine expression , 2013, Proceedings of the National Academy of Sciences.

[4]  I. Adcock,et al.  Coordinated regulation of IL-4 and IL-13 expression in human T cells: 3C analysis for DNA looping. , 2011, Biochemical and biophysical research communications.

[5]  P. Krawczyk,et al.  [Evaluation of Th1/Th2 lymphocyte balance and lipopolysaccharide receptor expression in asthma patients]. , 2009, Pneumonologia i alergologia polska.

[6]  M. Peck,et al.  Th1/Th2 Patterns and Balance in Cytokine Production in the Parents and Infants of a Large Birth Cohort1 , 2009, The Journal of Immunology.

[7]  Qutayba Hamid,et al.  Immunobiology of asthma. , 2009, Annual review of physiology.

[8]  J. Strouboulis,et al.  Locus control region mediated regulation of adult β‐globin gene expression , 2008, Journal of cellular biochemistry.

[9]  Young-Cheol Lee Synergistic Effect of Various Regulatory Factors in Th1/Th2 Balance; Immunotherapeutic Approaches in Asthma , 2008, International journal of biomedical science : IJBS.

[10]  R. Flavell,et al.  Demethylation of a specific hypersensitive site in the Th2 locus control region , 2007, Proceedings of the National Academy of Sciences.

[11]  M. Kubo,et al.  Regulation of the Il4 Gene Is Independently Controlled by Proximal and Distal 3′ Enhancers in Mast Cells and Basophils , 2007, Molecular and Cellular Biology.

[12]  M. Miyazaki,et al.  Chromatin remodeling at the Th2 cytokine gene loci in human type 2 helper T cells. , 2007, Molecular immunology.

[13]  B. Adkins,et al.  Murine Neonatal CD4+ Cells Are Poised for Rapid Th2 Effector-Like Function1 , 2007, The Journal of Immunology.

[14]  Bogdan Tanasa,et al.  Regulation of Th2 differentiation and Il4 locus accessibility. , 2006, Annual review of immunology.

[15]  M. Takemura,et al.  Age‐related changes in intracellular cytokine profiles and Th2 dominance in allergic children , 2006, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

[16]  C. Härtel,et al.  Cytokine responses correlate differentially with age in infancy and early childhood , 2005, Clinical and experimental immunology.

[17]  M. Gillman,et al.  TLR2 and TLR4 stimulation differentially induce cytokine secretion in human neonatal, adult, and murine mononuclear cells. , 2004, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

[18]  P. Kidd Th1/Th2 balance: the hypothesis, its limitations, and implications for health and disease. , 2003, Alternative medicine review : a journal of clinical therapeutic.

[19]  R. Flavell,et al.  Regulation of the Th2 cytokine locus by a locus control region. , 2003, Immunity.

[20]  P. Holt,et al.  Differential Patterns of Methylation of the IFN-γ Promoter at CpG and Non-CpG Sites Underlie Differences in IFN-γ Gene Expression Between Human Neonatal and Adult CD45RO− T Cells1 , 2002, The Journal of Immunology.

[21]  A. N. Pedersen,et al.  Is ageing associated with a shift in the balance between Type 1 and Type 2 cytokines in humans? , 2002, Clinical and experimental immunology.

[22]  C. Yen,et al.  Age-Associated Changes in Interferon-γ and Interleukin-4 Secretion by Purified Human CD4+ and CD8+ T Cells , 2000, Journal of Biomedical Science.

[23]  W. Miller,et al.  Identification of a coordinate regulator of interleukins 4, 13, and 5 by cross-species sequence comparisons. , 2000, Science.

[24]  P. Zielenkiewicz,et al.  Mammalian DNA methyltransferases. , 2006, Acta biochimica Polonica.

[25]  R. Flavell,et al.  Hypersensitive site 7 of the TH2 locus control region is essential for expressing TH2 cytokine genes and for long-range intrachromosomal interactions , 2005, Nature Immunology.

[26]  P. Holt,et al.  Differential patterns of methylation of the IFN-gamma promoter at CpG and non-CpG sites underlie differences in IFN-gamma gene expression between human neonatal and adult CD45RO- T cells. , 2002, Journal of immunology.

[27]  C. Yen,et al.  Age-associated changes in interferon-gamma and interleukin-4 secretion by purified human CD4+ and CD8+ T cells. , 2000, Journal of biomedical science.