Specific Inhibition of Phosphodiesterase-4B Results in Anxiolysis and Facilitates Memory Acquisition

[1]  C. Davies,et al.  GSK356278, a Potent, Selective, Brain-Penetrant Phosphodiesterase 4 Inhibitor That Demonstrates Anxiolytic and Cognition-Enhancing Effects without Inducing Side Effects in Preclinical Species , 2014, The Journal of Pharmacology and Experimental Therapeutics.

[2]  Blake A. Richards,et al.  Hippocampal Neurogenesis Regulates Forgetting During Adulthood and Infancy , 2014, Science.

[3]  D. Clair,et al.  DISC1 as a genetic risk factor for schizophrenia and related major mental illness: response to Sullivan , 2014, Molecular Psychiatry.

[4]  F. Menniti,et al.  PDE4 as a target for cognition enhancement , 2013, Expert opinion on therapeutic targets.

[5]  S. Satake,et al.  Enhanced inhibitory neurotransmission in the cerebellar cortex of Atp1a3‐deficient heterozygous mice , 2013, The Journal of physiology.

[6]  A. Arnsten,et al.  Constellation of HCN channels and cAMP regulating proteins in dendritic spines of the primate prefrontal cortex: potential substrate for working memory deficits in schizophrenia. , 2013, Cerebral cortex.

[7]  Mizuki Takahashi,et al.  Identification of the fused bicyclic 4-amino-2-phenylpyrimidine derivatives as novel and potent PDE4 inhibitors. , 2013, Bioorganic & medicinal chemistry letters.

[8]  J. Pratt,et al.  Alternating Hemiplegia of Childhood-Related Neural and Behavioural Phenotypes in Na+,K+-ATPase α3 Missense Mutant Mice , 2013, PloS one.

[9]  Huanming Yang,et al.  Association of PDE4B polymorphisms and schizophrenia in Northwestern Han Chinese , 2012, Human Genetics.

[10]  Kenneth R. Light,et al.  General learning ability regulates exploration through its influence on rate of habituation , 2011, Behavioural Brain Research.

[11]  A. Blokland,et al.  Enhanced long-term depression and impaired reversal learning in phosphodiesterase 4B-knockout (PDE4B −/−) mice , 2011, Neuropharmacology.

[12]  J. Roder,et al.  Disc1 Point Mutations in Mice Affect Development of the Cerebral Cortex , 2011, The Journal of Neuroscience.

[13]  Han-Ting Zhang,et al.  Prevention of cerebral ischemia-induced memory deficits by inhibition of phosphodiesterase-4 in rats , 2011, Metabolic Brain Disease.

[14]  J. O'Donnell,et al.  Phosphodiesterase-4D Knock-Out and RNA Interference-Mediated Knock-Down Enhance Memory and Increase Hippocampal Neurogenesis via Increased cAMP Signaling , 2011, The Journal of Neuroscience.

[15]  E. Karran,et al.  Quantitative comparison of phosphodiesterase mRNA distribution in human brain and peripheral tissues , 2010, Neuropharmacology.

[16]  J. Palacios,et al.  The human area postrema and other nuclei related to the emetic reflex express cAMP phosphodiesterases 4B and 4D , 2010, Journal of Chemical Neuroanatomy.

[17]  H. Marie,et al.  Synaptic Adaptations of CA1 Pyramidal Neurons Induced by a Highly Effective Combinational Antidepressant Therapy , 2010, Biological Psychiatry.

[18]  Chunfu Wu,et al.  Regulation of amygdalar PKA by β-arrestin-2/phosphodiesterase-4 complex is critical for fear conditioning , 2009, Proceedings of the National Academy of Sciences.

[19]  J. Kennedy,et al.  Genetic association and post-mortem brain mRNA analysis of DISC1 and related genes in schizophrenia , 2009, Schizophrenia Research.

[20]  O. Arancio,et al.  Reversal of long-term dendritic spine alterations in Alzheimer disease models , 2009, Proceedings of the National Academy of Sciences.

[21]  J. Roder,et al.  NCS-1 in the Dentate Gyrus Promotes Exploration, Synaptic Plasticity, and Rapid Acquisition of Spatial Memory , 2009, Neuron.

[22]  R. Tsujita,et al.  Discovery of selective PDE4B inhibitors. , 2009, Bioorganic & medicinal chemistry letters.

[23]  J. Suvisaari,et al.  Association Between Genes of Disrupted in Schizophrenia 1 (DISC1) Interactors and Schizophrenia Supports the Role of the DISC1 Pathway in the Etiology of Major Mental Illnesses , 2009, Biological Psychiatry.

[24]  J. O'Donnell,et al.  Antidepressant- and anxiolytic-like effects of the phosphodiesterase-4 (PDE4) inhibitor rolipram on behavior depend on cyclic AMP-response element binding protein (CREB)-mediated neurogenesis in the hippocampus , 2009, Neuropsychopharmacology.

[25]  Han-Ting Zhang Cyclic AMP-specific phosphodiesterase-4 as a target for the development of antidepressant drugs. , 2009, Current pharmaceutical design.

[26]  Ingrid Agartz,et al.  Association study of PDE4B gene variants in scandinavian schizophrenia and bipolar disorder multicenter case–control samples , 2009, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

[27]  G. Baillie Compartmentalized signalling: spatial regulation of cAMP by the action of compartmentalized phosphodiesterases , 2009, The FEBS journal.

[28]  Joseph E LeDoux Emotion circuits in the brain. , 2009, Annual review of neuroscience.

[29]  Hongwei Song,et al.  Positive association of the PDE4B (phosphodiesterase 4B) gene with schizophrenia in the Japanese population. , 2008, Journal of psychiatric research.

[30]  R. Roesler,et al.  Amelioration of recognition memory impairment associated with iron loading or aging by the type 4-specific phosphodiesterase inhibitor rolipram in rats , 2008, Neuropharmacology.

[31]  Kenneth R. Light,et al.  Up-regulation of exploratory tendencies does not enhance general learning abilities in juvenile or young-adult outbred mice , 2008, Neurobiology of Learning and Memory.

[32]  J. O'Donnell,et al.  Anxiogenic-Like Behavioral Phenotype of Mice Deficient in Phosphodiesterase 4B (PDE4B) , 2008, Neuropsychopharmacology.

[33]  S. Paciga,et al.  PDE4B polymorphisms and decreased PDE4B expression are associated with schizophrenia , 2008, Schizophrenia Research.

[34]  J. Siuciak,et al.  Behavioral and neurochemical characterization of mice deficient in the phosphodiesterase-4B (PDE4B) enzyme , 2008, Psychopharmacology.

[35]  J. Palacios,et al.  Differential distribution of PDE4B splice variant mRNAs in rat brain and the effects of systemic administration of LPS in their expression , 2008, Synapse.

[36]  D. Porteous,et al.  Isoform-Selective Susceptibility of DISC1/Phosphodiesterase-4 Complexes to Dissociation by Elevated Intracellular cAMP Levels , 2007, The Journal of Neuroscience.

[37]  J. Castle,et al.  PDE4B5, a Novel, Super-Short, Brain-Specific cAMP Phosphodiesterase-4 Variant Whose Isoform-Specifying N-Terminal Region Is Identical to That of cAMP Phosphodiesterase-4D6 (PDE4D6) , 2007, Journal of Pharmacology and Experimental Therapeutics.

[38]  D. Blackwood,et al.  The PDE4B gene confers sex-specific protection against schizophrenia , 2007, Psychiatric genetics.

[39]  J. Boothroyd,et al.  Behavioral changes induced by Toxoplasma infection of rodents are highly specific to aversion of cat odors , 2007, Proceedings of the National Academy of Sciences.

[40]  J. Siuciak,et al.  Antipsychotic profile of rolipram: efficacy in rats and reduced sensitivity in mice deficient in the phosphodiesterase-4B (PDE4B) enzyme , 2007, Psychopharmacology.

[41]  Justin Toupin,et al.  Electrical stimulation protocols for hippocampal synaptic plasticity and neuronal hyper-excitability: Are they effective or relevant? , 2007, Experimental Neurology.

[42]  I. Izquierdo,et al.  Persistence of Long-Term Memory Storage Requires a Late Protein Synthesis- and BDNF- Dependent Phase in the Hippocampus , 2007, Neuron.

[43]  Louis D. Matzel,et al.  Exploration in outbred mice covaries with general learning abilities irrespective of stress reactivity, emotionality, and physical attributes , 2006, Neurobiology of Learning and Memory.

[44]  F. Menniti,et al.  Phosphodiesterases in the CNS: targets for drug development , 2006, Nature Reviews Drug Discovery.

[45]  Jennifer E. Chubb,et al.  DISC1 and PDE4B Are Interacting Genetic Factors in Schizophrenia That Regulate cAMP Signaling , 2005, Science.

[46]  刘金明,et al.  IL-13受体α2降低血吸虫病肉芽肿的炎症反应并延长宿主存活时间[英]/Mentink-Kane MM,Cheever AW,Thompson RW,et al//Proc Natl Acad Sci U S A , 2005 .

[47]  J. Frey,et al.  Phosphodiesterase 4B (PDE4B) and cAMP-level regulation within different tissue fractions of rat hippocampal slices during long-term potentiation in vitro , 2005, Brain Research.

[48]  T. Gould,et al.  Rolipram attenuates MK-801-induced deficits in latent inhibition. , 2005, Behavioral neuroscience.

[49]  O. Vitolo,et al.  Persistent improvement in synaptic and cognitive functions in an Alzheimer mouse model after rolipram treatment. , 2004, The Journal of clinical investigation.

[50]  Jin Hwan Kim,et al.  Structure of the catalytic domain of human phosphodiesterase 5 with bound drug molecules , 2003, Nature.

[51]  C. Florian,et al.  Involvement of the hippocampal CA3-region in acquisition and in memory consolidation of spatial but not in object information in mice , 2003, Neurobiology of Learning and Memory.

[52]  R. Bourtchouladze,et al.  Targeting the CREB pathway for memory enhancers , 2003, Nature Reviews Drug Discovery.

[53]  N. Thomson,et al.  Molecular cloning and subcellular distribution of the novel PDE4B4 cAMP-specific phosphodiesterase isoform. , 2003, The Biochemical journal.

[54]  R. Lefkowitz,et al.  Retraction for Baillie et al., β-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates β-adrenoceptor switching from Gs to Gi , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[55]  S. Jin,et al.  Deletion of phosphodiesterase 4D in mice shortens alpha(2)-adrenoceptor-mediated anesthesia, a behavioral correlate of emesis. , 2002, The Journal of clinical investigation.

[56]  T. Bonhoeffer,et al.  Kinase-Independent Requirement of EphB2 Receptors in Hippocampal Synaptic Plasticity , 2001, Neuron.

[57]  D J Porteous,et al.  Schizophrenia and affective disorders--cosegregation with a translocation at chromosome 1q42 that directly disrupts brain-expressed genes: clinical and P300 findings in a family. , 2001, American journal of human genetics.

[58]  T. Kronbach,et al.  Identification of inhibitor binding sites of the cAMP-specific phosphodiesterase 4. , 2001, Cellular signalling.

[59]  J. Palacios,et al.  Phosphodiesterase type 4 isozymes expression in human brain examined by in situ hybridization histochemistry and [3H]rolipram binding autoradiography Comparison with monkey and rat brain , 2000, Journal of Chemical Neuroanatomy.

[60]  G. Feng,et al.  Imaging Neuronal Subsets in Transgenic Mice Expressing Multiple Spectral Variants of GFP , 2000, Neuron.

[61]  G. Baillie,et al.  Sub‐family selective actions in the ability of Erk2 MAP kinase to phosphorylate and regulate the activity of PDE4 cyclic AMP‐specific phosphodiesterases , 2000, British journal of pharmacology.

[62]  J. O'Donnell,et al.  Inhibition of Cyclic AMP Phosphodiesterase (PDE4) Reverses Memory Deficits Associated with NMDA Receptor Antagonism , 2000, Neuropsychopharmacology.

[63]  J. Cherry,et al.  Cyclic AMP phosphodiesterases are localized in regions of the mouse brain associated with reinforcement, movement, and affect , 1999, The Journal of comparative neurology.

[64]  J. Palacios,et al.  Effects of rolipram on the elevated plus-maze test in rats: a preliminary study , 1999, Journal of psychopharmacology.

[65]  L. Slipczuk,et al.  Attenuating the persistence of fear memory storage using a single dose of antidepressant , 2013, Molecular Psychiatry.

[66]  R. Lefkowitz,et al.  beta-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates beta-adrenoceptor switching from Gs to Gi. , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[67]  Prof. Dr. W. Wolfgang Fleischhacker,et al.  Neuropsychopharmacology , 2003, Journal of Neural Transmission. Supplementa.

[68]  R. Duman,et al.  Administration of a cAMP Phosphodiesterase 4 Inhibitor Enhances Antidepressant-Induction of BDNF mRNA in Rat Hippocampus , 2000, Neuropsychopharmacology.