Biosynthesis of 3″-demethyl-gentamicin C components by genN disruption strain of Micromonospora echinospora and test their antimicrobial activities in vitro.

[1]  Huiyuan Gao,et al.  Biosynthesis of Epimers C2 and C2a in the Gentamicin C Complex , 2015, Chembiochem : a European journal of chemical biology.

[2]  P. Leadlay,et al.  Delineating the Biosynthesis of Gentamicin X2, the Common Precursor of the Gentamicin C Antibiotic Complex , 2015, Chemistry & biology.

[3]  Hongyu Zhang,et al.  Genetic engineering combined with random mutagenesis to enhance G418 production in Micromonospora echinospora , 2014, Journal of Industrial Microbiology & Biotechnology.

[4]  Hongyu Zhang,et al.  Construction of a gentamicin C1a-overproducing strain of Micromonospora purpurea by inactivation of the gacD gene. , 2013, Microbiological research.

[5]  Hung‐wen Liu,et al.  GenK-catalyzed C-6' methylation in the biosynthesis of gentamicin: isolation and characterization of a cobalamin-dependent radical SAM enzyme. , 2013, Journal of the American Chemical Society.

[6]  A. Van Schepdael,et al.  Impurity profiling of micronomicin sulfate injection by liquid chromatography-ion trap mass spectrometry. , 2013, Journal of pharmaceutical and biomedical analysis.

[7]  H. Kwon,et al.  Gene inactivation study on gntK, a putative C-methyltransferase gene in gentamicin biosynthesis from Micromonospora echinospora , 2012, Journal of the Korean Society for Applied Biological Chemistry.

[8]  B. Ko,et al.  Discrimination of korean Rehmannia glutinosa from chinese Rehmannia glutinosa using sequence-characterized amplified region marker , 2012, Journal of the Korean Society for Applied Biological Chemistry.

[9]  W. Hong,et al.  Identification of gntK, a gene required for the methylation of purpurosamine C-6' in gentamicin biosynthesis. , 2012, The Journal of general and applied microbiology.

[10]  W. Piepersberg,et al.  The oxidoreductases LivQ and NeoQ are responsible for the different 6′‐modifications in the aminoglycosides lividomycin and neomycin , 2011, Journal of applied microbiology.

[11]  Dan-yi Li,et al.  Construction of kanamycin B overproducing strain by genetic engineering of Streptomyces tenebrarius , 2011, Applied Microbiology and Biotechnology.

[12]  Thi Huyen Phan,et al.  Gene inactivation study of gntE reveals its role in the first step of pseudotrisaccharide modifications in gentamicin biosynthesis. , 2008, Biochemical and biophysical research communications.

[13]  Won Seok Jung,et al.  Genetic dissection of the biosynthetic route to gentamicin A2 by heterologous expression of its minimal gene set , 2008, Proceedings of the National Academy of Sciences.

[14]  A. Truman,et al.  Characterization of the enzyme BtrD from Bacillus circulans and revision of its functional assignment in the biosynthesis of butirosin. , 2007, Angewandte Chemie.

[15]  N. Koorbanally,et al.  Elaboration of Neosamine Rings in the Biosynthesis of Neomycin and Butirosin , 2007, Chembiochem : a European journal of chemical biology.

[16]  K. Aboshanab Genetic studies on the biosynthesis of the major aminoglycoside antibiotics: Isolation, analysis and comparison of the biosynthetic gene clusters for 12 aminoglycoside antibiotics , 2007 .

[17]  B. Molitoris,et al.  A non-nephrotoxic gentamicin congener that retains antimicrobial efficacy. , 2006, Journal of the American Society of Nephrology : JASN.

[18]  J. Sohng,et al.  The ribostamycin biosynthetic gene cluster in Streptomyces ribosidificus: comparison with butirosin biosynthesis. , 2005, Molecules and cells.

[19]  T. Mironenko,et al.  The neomycin biosynthetic gene cluster of Streptomyces fradiae NCIMB 8233: characterisation of an aminotransferase involved in the formation of 2-deoxystreptamine. , 2005, Organic & biomolecular chemistry.

[20]  J. Sohng,et al.  A gene cluster for biosynthesis of kanamycin from Streptomyces kanamyceticus: comparison with gentamicin biosynthetic gene cluster. , 2004, Archives of biochemistry and biophysics.

[21]  J. Sohng,et al.  Molecular cloning and characterization of a 2-deoxystreptamine biosynthetic gene cluster in gentamicin-producing Micromonospora echinospora ATCC15835. , 2004, Molecules and cells.

[22]  E. Wellington,et al.  Gene cluster in Micromonospora echinospora ATCC15835 for the biosynthesis of the gentamicin C complex. , 2004, The Journal of antibiotics.

[23]  J. Sohng,et al.  Isolation and characterization of the tobramycin biosynthetic gene cluster from Streptomyces tenebrarius. , 2004, FEMS microbiology letters.

[24]  B. Kerem,et al.  Gentamicin-induced correction of CFTR function in patients with cystic fibrosis and CFTR stop mutations. , 2003, The New England journal of medicine.

[25]  U. Holzgrabe,et al.  Assignment of the major and minor components of gentamicin for evaluation of batches , 2003 .

[26]  T. Eguchi,et al.  Butirosin-biosynthetic gene cluster from Bacillus circulans. , 2000, The Journal of antibiotics.

[27]  T. Kieser Practical streptomyces genetics , 2000 .

[28]  J. Puglisi,et al.  Structural origins of gentamicin antibiotic action , 1998, The EMBO journal.

[29]  M. Bibb,et al.  Derivatives of pUC18 that have BglII sites flanking a modified multiple cloning site and that retain the ability to identify recombinant clones by visual screening of Escherichia coli colonies. , 1993, Gene.

[30]  K. O'Brien,et al.  Plasmid cloning vectors for the conjugal transfer of DNA from Escherichia coli to Streptomyces spp. , 1992, Gene.

[31]  D. Macneil,et al.  Analysis of Streptomyces avermitilis genes required for avermectin biosynthesis utilizing a novel integration vector. , 1992, Gene.

[32]  J. Gyimesi,et al.  Metabolites of gentamicin-producing Micromonospora species I. Isolation and identification of metabolites. , 1977, The Journal of antibiotics.

[33]  M. Yudis,et al.  The gentamicin antibiotics. Part III. The gross structures of the gentamicin C components , 1971 .