ANCA-associated Goodpasture's syndrome in a patient with rheumatoid arthritis on penicillamine

Although penicillamine has been used effectively in the management of a variety of diseases, several adverse reactions have been observed with prolonged administration of this agent. We report a case of Goodpasture's syndrome, as a result of induction of anti-myeloperoxidase antineutrophil cytoplasmic antibodies in a 51 year old man who was being treated with this drug for rheumatoid arthritis. This pulmonary-renal syndrome has been described on rare occasions in patients receiving penicillamine. Treatment with steroids and cyclophosphamide resulted in pulmonary and renal functional recovery.

[1]  F. Bienaimé,et al.  D-Penicillamine-induced ANCA-associated crescentic glomerulonephritis in Wilson disease. , 2007, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[2]  S. Jimenez,et al.  Goodpasture-like syndrome induced by D-penicillamine in a patient with systemic sclerosis: report and review of the literature. , 2003, The Journal of rheumatology.

[3]  N. Kamatani,et al.  Rapidly progressive glomerulonephritis with D-penicillamine. , 2000, The American journal of the medical sciences.

[4]  C. Lockwood,et al.  Antigen specificity in hydralazine associated ANCA positive systemic vasculitis. , 1995, QJM : monthly journal of the Association of Physicians.

[5]  C. Pusey,et al.  Goodpaststure-like syndrome associated with anti-myeloperoxidase antibodies following pencillamine treatment , 1995 .

[6]  H. Peter,et al.  ANCA in diseases other than systemic vasculitis , 1993, Clinical and experimental immunology.

[7]  M. Goldman,et al.  TH2 cells in systemic autoimmunity: insights from allogeneic diseases and chemically-induced autoimmunity. , 1991, Immunology today.

[8]  R. Falk,et al.  Anti-neutrophil cytoplasmic autoantibodies with specificity for myeloperoxidase in patients with systemic vasculitis and idiopathic necrotizing and crescentic glomerulonephritis. , 1988, The New England journal of medicine.

[9]  A. Muijsers,et al.  Antiarthritic drugs containing thiol groups scavenge hypochlorite and inhibit its formation by myeloperoxidase from human leukocytes. A therapeutic mechanism of these drugs in rheumatoid arthritis? , 1985, Arthritis and rheumatism.

[10]  J. Hayes,et al.  Penicillamine-induced "Goodpasture's syndrome": successful treatment of a fulminant case. , 1981, Australian and New Zealand journal of medicine.

[11]  M. Kaplan,et al.  D-Penicillamine-induced Goodpasture's-like syndrome in primary biliary cirrhosis--successful treatment with plasmapheresis and immunosuppressives. , 1980, Gastroenterology.

[12]  I. Sternlieb,et al.  D-penicillamine induced Goodpasture's syndrome in Wilson's disease. , 1975, Annals of internal medicine.

[13]  J. Cameron,et al.  Lupus Nephritis , 1959, Clinics in rheumatic diseases.

[14]  I. Ohno.  [D-penicillamine nephropathy]. , 1997, Ryoikibetsu shokogun shirizu.

[15]  C. Pusey,et al.  Goodpasture-like syndrome associated with anti-myeloperoxidase antibodies following penicillamine treatment. , 1995, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[16]  J. Walshe.  Penicillamine and the SLE syndrome. , 1981, The Journal of rheumatology. Supplement.

[17]  Walshe Jm.  Penicillamine and the SLE syndrome. , 1981 .

[18]  F. McGinty,et al.  Penicillamine nephropathy. , 1980, Nephron.

[19]  H. Hill.  Penicillamine in rheumatoid arthritis: adverse effects. , 1979, Scandinavian journal of rheumatology. Supplement.

[20]  T. Gibson,et al.  Goodpasture Syndrome and D-Penicillamine , 1976 .