Development of a 6-DOF robotic test system for studying the biomechanics of total knee replacement

A robotic-based joint testing system for studying the biomechanics of Total Knee Arthroplasty (TKA) was developed in this project. The system is composed of a 6 Degree-of-Freedom (DOF) robotic manipulator (Kawasaki UZ150*) and a 6-DOF universal force-moment sensor (JR3*). This testing system offers the ability to operate with force and displacement controls and is capable of characterizing the in-vitro kinematics and the in-situ forces in tissue components of the human knee. In a knee test, the femur is rigidly fixed on a pedestal while the tibia is rigidly mounted to the robot arm through the load cell. This robotic system determines the kinematics response of the knee under various external-loading conditions. The kinematics data can then be reproduced on the knee specimen. Upon simulation of knee motion, forces and displacements are evaluated from the load cell and the robot, respectively. Various TKA designs can be tested on the same specimen where the native knee is used as the reference for the evaluation of the biomechanical response of the TKA. The system could be further modified to determine optimal designs of various artificial joint replacements, using normal joint biomechanics as an objective function. Thesis Supervisor: Guoan Li Title: Assistant Professor of Orthopedic Surgery/Bioengineering, Harvard Medical School Thesis Supervisor: Derek Rowell Title: Professor of Mechanical Engineering

[1]  K. C. Gupta,et al.  An historical note on finite rotations , 1989 .

[2]  S Arai,et al.  The use of robotics technology to study human joint kinematics: a new methodology. , 1993, Journal of biomechanical engineering.

[3]  R. Laskin,et al.  The Insall Award. Total knee replacement with posterior cruciate ligament retention in rheumatoid arthritis. Problems and complications. , 1997, Clinical orthopaedics and related research.

[4]  P. Walker,et al.  Stabilizing mechanisms of the loaded and unloaded knee joint. , 1976, The Journal of bone and joint surgery. American volume.

[5]  K. Markolf,et al.  The role of joint load in knee stability. , 1981, The Journal of bone and joint surgery. American volume.

[6]  J. Insall,et al.  Presidential address to The Knee Society. Choices and compromises in total knee arthroplasty. , 1988, Clinical orthopaedics and related research.

[7]  Audra E. Kosh,et al.  Linear Algebra and its Applications , 1992 .

[8]  J L Lewis,et al.  6R instrumented spatial linkages for anatomical joint motion measurement--Part 1: Design. , 1992, Journal of biomechanical engineering.

[9]  M L Hull,et al.  Implementation of a five degree of freedom automated system to determine knee flexibility in vitro. , 1990, Journal of biomechanical engineering.

[10]  P R Cavanagh,et al.  Three-dimensional kinematics of the human knee during walking. , 1992, Journal of biomechanics.

[11]  S Hirokawa.  Biomechanics of the knee joint: a critical review. , 1993, Critical reviews in biomedical engineering.

[12]  D A Dennis,et al.  In Vivo Knee Kinematics Derived Using an Inverse Perspective Technique , 1996, Clinical orthopaedics and related research.

[13]  William H. Press,et al.  Numerical recipes , 1990 .

[14]  L Blankevoort,et al.  Ligament-bone interaction in a three-dimensional model of the knee. , 1991, Journal of biomechanical engineering.

[15]  R. Pelker,et al.  Rollback in posterior cruciate ligament-retaining total knee arthroplasty. A radiographic analysis. , 1997, The Journal of arthroplasty.

[16]  G A Livesay,et al.  A combined robotic/universal force sensor approach to determine in situ forces of knee ligaments. , 1996, Journal of biomechanics.

[17]  J. Macdermid,et al.  Effect of the posterior cruciate ligament in knee-joint proprioception in total knee arthroplasty. , 1998, The Journal of arthroplasty.

[18]  Göran Selvik,et al.  Chronic anterolateral instability of the knee , 1989, The American journal of sports medicine.

[19]  J D Reuben,et al.  Three-dimensional dynamic motion analysis of the anterior cruciate ligament deficient knee joint , 1989, The American journal of sports medicine.

[20]  R. Stephenson.  A and V , 1962, The British journal of ophthalmology.

[21]  V. Goldberg,et al.  Decreased posterior tibial slope increases strain in the posterior cruciate ligament following total knee arthroplasty. , 1996, The Journal of arthroplasty.

[22]  S R Simon,et al.  Quantitative gait analysis after total knee arthroplasty for monarticular degenerative arthritis. , 1983, The Journal of bone and joint surgery. American volume.

[23]  B. Beynnon,et al.  Posterior cruciate ligament strain biomechanics in total knee arthroplasty. , 1994, Clinical Orthopaedics and Related Research.

[24]  G L Kinzel,et al.  Measurement of the total motion between two body segments. I. Analytical development. , 1972, Journal of biomechanics.

[25]  W. Seering,et al.  The function of the primary ligaments of the knee in anterior-posterior and medial-lateral motions. , 1980, Journal of biomechanics.

[26]  R van Dijk,et al.  Roentgen stereophotogrammetric methods for the evaluation of the three dimensional kinematic behaviour and cruciate ligament length patterns of the human knee joint. , 1979, Journal of biomechanics.

[27]  A. J. van den Bogert,et al.  Effect of skin movement on the analysis of skeletal knee joint motion during running. , 1997, Journal of biomechanics.

[28]  L. C. Detenbeck.  Function of the cruciate ligaments in knee stability , 1974, The Journal of sports medicine.

[29]  G L Kinzel,et al.  Measurement of the total motion between two body segments. II. Description of application. , 1972, Journal of biomechanics.

[30]  J. Moreland.  Mechanisms of failure in total knee arthroplasty. , 1988, Clinical orthopaedics and related research.

[31]  R. Warren,et al.  The structure of the posterolateral aspect of the knee. , 1982, The Journal of bone and joint surgery. American volume.

[32]  C. H. Edwards,et al.  Calculus with analytic geometry , 1994 .

[33]  G. Smidt.  Biomechanical analysis of knee flexion and extension. , 1973, Journal of biomechanics.

[34]  R Huiskes,et al.  Measurement errors in roentgen-stereophotogrammetric joint-motion analysis. , 1990, Journal of biomechanics.

[35]  F. Noyes,et al.  Biomechanics of the knee extension exercise , 1983 .

[36]  J. Black,et al.  Materials design analysis of the prosthetic anterior cruciate ligament. , 1980, Journal of biomedical materials research.

[37]  P S Walker,et al.  The load-bearing area in the knee joint. , 1972, Journal of biomechanics.

[38]  H. Miura,et al.  Effect of Partial Release of the Posterior Cruciate Ligament in Total Knee Arthroplasty , 1998, Clinical orthopaedics and related research.

[39]  E. Chao,et al.  Justification of triaxial goniometer for the measurement of joint rotation. , 1980, Journal of biomechanics.

[40]  Docteur Paul G. J. Maquet,et al.  Biomechanics of the Knee , 1984, Springer Berlin Heidelberg.

[41]  J. Andrews,et al.  Classification of knee ligament instabilities. Part I. The medial compartment and cruciate ligaments. , 1976, The Journal of bone and joint surgery. American volume.

[42]  J. Andrews,et al.  Classification of knee ligament instabilities. Part II. The lateral compartment. , 1976, The Journal of bone and joint surgery. American volume.

[43]  J. Johnson,et al.  Posterior cruciate recession in total knee arthroplasty. , 1997, The Journal of arthroplasty.

[44]  R Huiskes,et al.  Analytical stereophotogrammetric determination of three-dimensional knee-joint geometry. , 1985, Journal of biomechanics.

[45]  P ? ? ? ? ? ? ? % ? ? ? ? , 1991 .

[46]  S. Stern,et al.  Posterior stabilized prosthesis. Results after follow-up of nine to twelve years. , 1992, The Journal of bone and joint surgery. American volume.

[47]  J L Lewis,et al.  Description and error evaluation of an in vitro knee joint testing system. , 1988, Journal of biomechanical engineering.

[48]  M. Freeman,et al.  Should the posterior cruciate ligament be retained or resected in condylar nonmeniscal knee arthroplasty? The case for resection. , 1988, The Journal of arthroplasty.

[49]  R. Hunter,et al.  The anterior cruciate ligament. , 2017 .

[50]  M. Ritter,et al.  Long-term survival analysis of a posterior cruciate-retaining total condylar total knee arthroplasty. , 1994, Clinical orthopaedics and related research.

[51]  E. Abdel-Rahman,et al.  A two-dimensional dynamic anatomical model of the human knee joint. , 1993, Journal of biomechanical engineering.

[52]  J L Lewis,et al.  The effect of knee-prosthesis geometry on cruciate ligament mechanics during flexion. , 1982, The Journal of bone and joint surgery. American volume.

[53]  R. Cailliet.  Knee pain and disability , 1973 .

[54]  Freddie H. Fu,et al.  Determination of the in situ loads on the human anterior cruciate ligament , 1993, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[55]  L. Blankevoort,et al.  The envelope of passive knee joint motion. , 1988, Journal of biomechanics.

[56]  T P Andriacchi,et al.  Retention of the posterior cruciate in total knee arthroplasty. , 1988, The Journal of arthroplasty.

[57]  M. Axe,et al.  The classification of knee ligament instability. , 1985, The Orthopedic clinics of North America.

[58]  J. Stiehl,et al.  Fluoroscopic analysis of kinematics after posterior-cruciate-retaining knee arthroplasty. , 1995, The Journal of bone and joint surgery. British volume.

[59]  C. Caldwell.  Mathematics of Computation , 1999 .

[60]  P. Walker,et al.  Ligament length patterns, strength, and rotational axes of the knee joint. , 1976, Clinical orthopaedics and related research.