Chitosan and Its Derivatives for Drug Delivery Perspective

[1]  M. Rekha,et al.  Bioadhesive hydrophobic chitosan microparticles for oral delivery of insulin: In vitro characterization and in vivo uptake studies , 2011 .

[2]  C. Sharma,et al.  In vitro evaluation of N-(2-hydroxy) propyl-3-trimethyl ammonium chitosan for oral insulin delivery , 2011 .

[3]  Peter Wick,et al.  Nanotoxicology: an interdisciplinary challenge. , 2011, Angewandte Chemie.

[4]  R. Franke,et al.  Inside Cover: A General and Efficient Iridium‐Catalyzed Hydroformylation of Olefins (Angew. Chem. Int. Ed. 1/2011) , 2011 .

[5]  M. Veiga,et al.  In vitro Evaluation of Acyclovir/Chitosan Floating Systems , 2010, Materials.

[6]  W. Jiskoot,et al.  Dual role of CpG as immune modulator and physical crosslinker in ovalbumin loaded N-trimethyl chitosan (TMC) nanoparticles for nasal vaccination. , 2010, Journal of controlled release : official journal of the Controlled Release Society.

[7]  M. Rekha,et al.  Dextran-protamine polycation: an efficient nonviral and haemocompatible gene delivery system. , 2010, Colloids and surfaces. B, Biointerfaces.

[8]  M. Tabrizian,et al.  Advances in using chitosan-based nanoparticles for in vitro and in vivo drug and gene delivery , 2010, Expert opinion on drug delivery.

[9]  S. Jon,et al.  A novel approach to oral delivery of insulin by conjugating with low molecular weight chitosan. , 2010, Bioconjugate chemistry.

[10]  Shantikumar V. Nair,et al.  Biomedical applications of chitin and chitosan based nanomaterials—A short review , 2010 .

[11]  T. Yen,et al.  Biodistribution, pharmacodynamics and pharmacokinetics of insulin analogues in a rat model: Oral delivery using pH-responsive nanoparticles vs. subcutaneous injection. , 2010, Biomaterials.

[12]  A. Nokhodchi,et al.  Development of pH-sensitive Insulin Nanoparticles using Eudragit L100-55 and Chitosan with Different Molecular Weights , 2010, AAPS PharmSciTech.

[13]  D. K. Majumdar,et al.  Eudragit S-100 entrapped chitosan microspheres of valdecoxib for colon cancer , 2010, Journal of materials science. Materials in medicine.

[14]  S. Gu,et al.  Thiolated trimethyl chitosan nanocomplexes as gene carriers with high in vitro and in vivo transfection efficiency. , 2010, Journal of controlled release : official journal of the Controlled Release Society.

[15]  Sun‐mi Lee,et al.  Galactosylated chitosan-g-PEI/DNA complexes-loaded poly(organophosphazene) hydrogel as a hepatocyte targeting gene delivery system , 2010, Archives of pharmacal research.

[16]  M. Rekha,et al.  Dextran-glycidyltrimethylammonium chloride conjugate/DNA nanoplex: A potential non-viral and haemocompatible gene delivery system. , 2010, International journal of pharmaceutics.

[17]  C. Sharma,et al.  Acyl modified chitosan derivatives for oral delivery of insulin and curcumin , 2010, Journal of materials science. Materials in medicine.

[18]  C. Sharma,et al.  Development and characterization of self-aggregated nanoparticles from anacardoylated chitosan as a carrier for insulin , 2010 .

[19]  I. Aranaz,et al.  Chitosan Amphiphilic Derivatives. Chemistry and Applications , 2010 .

[20]  Miqin Zhang,et al.  Chitosan-based hydrogels for controlled, localized drug delivery. , 2010, Advanced drug delivery reviews.

[21]  Ick Chan Kwon,et al.  Targeted delivery of low molecular drugs using chitosan and its derivatives. , 2010, Advanced drug delivery reviews.

[22]  Lichen Yin,et al.  Drug permeability and mucoadhesion properties of thiolated trimethyl chitosan nanoparticles in oral insulin delivery. , 2009, Biomaterials.

[23]  G. Bhat,et al.  The evaluation of a biodegradable dental chip containing chlorhexidine in chitosan base as a targeted drug delivery in the management of chronic periodontitis in patients , 2009 .

[24]  C. Pillai,et al.  Chitin and chitosan polymers: Chemistry, solubility and fiber formation , 2009 .

[25]  Chandra P Sharma,et al.  Synthesis and evaluation of lauryl succinyl chitosan particles towards oral insulin delivery and absorption. , 2009, Journal of controlled release : official journal of the Controlled Release Society.

[26]  Hsing-Wen Sung,et al.  In vivo evaluation of safety and efficacy of self-assembled nanoparticles for oral insulin delivery. , 2009, Biomaterials.

[27]  Changren Zhou,et al.  Polysaccharides-based nanoparticles as drug delivery systems. , 2008, Advanced drug delivery reviews.

[28]  K. M. Lin,et al.  Multi-ion-crosslinked nanoparticles with pH-responsive characteristics for oral delivery of protein drugs. , 2008, Journal of controlled release : official journal of the Controlled Release Society.

[29]  M. Rekha,et al.  Phthalyl Chitosan-Poly(ethylene oxide) Semi-Interpenetrating Polymer Network Microparticles for Oral Protein Delivery : An In Vitro Characterization , 2008 .

[30]  P. Nydert,et al.  Chitosan as a carrier for non‐viral gene transfer in a cystic‐fibrosis cell line , 2008, Biotechnology and applied biochemistry.

[31]  M. Prabaharan Review Paper: Chitosan Derivatives as Promising Materials for Controlled Drug Delivery , 2008, Journal of biomaterials applications.

[32]  Yu-Hsin Lin,et al.  Oral delivery of peptide drugs using nanoparticles self-assembled by poly(gamma-glutamic acid) and a chitosan derivative functionalized by trimethylation. , 2008, Bioconjugate chemistry.

[33]  I. Bravo-Osuna,et al.  Specific permeability modulation of intestinal paracellular pathway by chitosan-poly(isobutylcyanoacrylate) core-shell nanoparticles. , 2008, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[34]  M. Rafiee-Tehrani,et al.  Preparation and characterization of insulin nanoparticles using chitosan and its quaternized derivatives. , 2008, Nanomedicine : nanotechnology, biology, and medicine.

[35]  Nazma N. Inamdar,et al.  Chitosan-modifications and applications: Opportunities galore , 2008 .

[36]  Sanjay K. Jain,et al.  Target-specific drug release to the colon , 2008, Expert opinion on drug delivery.

[37]  T. Coviello,et al.  Recent advances and perspectives on coated alginate microspheres for modified drug delivery , 2008, Expert opinion on drug delivery.

[38]  S. Nie,et al.  Therapeutic Nanoparticles for Drug Delivery in Cancer Types of Nanoparticles Used as Drug Delivery Systems , 2022 .

[39]  Shirui Mao,et al.  Gene delivery using chitosan, trimethyl chitosan or polyethylenglycol-graft-trimethyl chitosan block copolymers: establishment of structure-activity relationships in vitro. , 2008, Journal of controlled release : official journal of the Controlled Release Society.

[40]  R. Khar,et al.  Development and characterization of chitosan succinate microspheres for the improved oral bioavailability of insulin. , 2007, Journal of pharmaceutical sciences.

[41]  P. Diwan,et al.  Effective oral delivery of insulin in animal models using vitamin B12-coated dextran nanoparticles. , 2007, Journal of controlled release : official journal of the Controlled Release Society.

[42]  C. Laurencin,et al.  Biodegradable polymers as biomaterials , 2007 .

[43]  B. Sarmento,et al.  Insulin-loaded alginate microspheres for oral delivery – Effect of polysaccharide reinforcement on physicochemical properties and release profile , 2007 .

[44]  B. Sarmento,et al.  Alginate/Chitosan Nanoparticles are Effective for Oral Insulin Delivery , 2007, Pharmaceutical Research.

[45]  Tommasina Coviello,et al.  Polysaccharide hydrogels for modified release formulations. , 2007, Journal of controlled release : official journal of the Controlled Release Society.

[46]  Y. Sultana,et al.  Chitosan Phthalate Microspheres for Oral Delivery of Insulin: Preparation, Characterization, and In Vitro Evaluation , 2007, Drug delivery.

[47]  B. Sarmento,et al.  Development and characterization of new insulin containing polysaccharide nanoparticles. , 2006, Colloids and surfaces. B, Biointerfaces.

[48]  Aldo R Boccaccini,et al.  Processing and characterization of porous structures from chitosan and starch for tissue engineering scaffolds. , 2006, Biomacromolecules.

[49]  Cui Tang,et al.  Chitosan graft copolymer nanoparticles for oral protein drug delivery: preparation and characterization. , 2006, Biomacromolecules.

[50]  Gerrit Borchard,et al.  Uptake studies in rat Peyer's patches, cytotoxicity and release studies of alginate coated chitosan nanoparticles for mucosal vaccination. , 2006, Journal of controlled release : official journal of the Controlled Release Society.

[51]  Swarnlata Saraf,et al.  Nanocarriers: promising vehicle for bioactive drugs. , 2006, Biological & pharmaceutical bulletin.

[52]  T. E. Abraham,et al.  Polyionic hydrocolloids for the intestinal delivery of protein drugs: alginate and chitosan--a review. , 2006, Journal of controlled release : official journal of the Controlled Release Society.

[53]  David J Mooney,et al.  Alginate hydrogels as biomaterials. , 2006, Macromolecular bioscience.

[54]  M. Rinaudo,et al.  Chitin and chitosan: Properties and applications , 2006 .

[55]  P. Couvreur,et al.  Nanotechnology: Intelligent Design to Treat Complex Disease , 2006, Pharmaceutical Research.

[56]  Shizuka Yamada,et al.  Chitosan monomer promotes tissue regeneration on dental pulp wounds. , 2006, Journal of biomedical materials research. Part A.

[57]  Sanyog Jain,et al.  Chitosan nanoparticles encapsulated vesicular systems for oral immunization: preparation, in‐vitro and in‐vivo characterization , 2006, The Journal of pharmacy and pharmacology.

[58]  R. Reis,et al.  GRAFT COPOLYMERIZED CHITOSAN-PRESENT STATUS AND APPLICATIONS , 2005 .

[59]  Nan-jin Zhou,et al.  [The role of local immune response in gastric mucosa in the protection induced by Helicobacter pylori vaccine with chitosan as adjuvant]. , 2005, Zhonghua yi xue za zhi.

[60]  D. Fischer,et al.  Uptake and Transport of PEG-Graft-Trimethyl-Chitosan Copolymer–Insulin Nanocomplexes by Epithelial Cells , 2005, Pharmaceutical Research.

[61]  A. Bernkop‐Schnürch,et al.  Preparation and in vitro evaluation of thiolated chitosan microparticles , 2005, Journal of microencapsulation.

[62]  Hsing-Wen Sung,et al.  Preparation of nanoparticles composed of chitosan/poly-gamma-glutamic acid and evaluation of their permeability through Caco-2 cells. , 2005, Biomacromolecules.

[63]  Y. Jeong,et al.  Drug release from core-shell type nanoparticles of poly(DL-lactide-co-glycolide)-grafted dextran , 2005, Journal of microencapsulation.

[64]  A. Domb,et al.  Chitosan chemistry and pharmaceutical perspectives. , 2004, Chemical reviews.

[65]  Tejraj M Aminabhavi,et al.  Recent advances on chitosan-based micro- and nanoparticles in drug delivery. , 2004, Journal of controlled release : official journal of the Controlled Release Society.

[66]  K. Leong,et al.  The effect of the degree of chitosan deacetylation on the efficiency of gene transfection. , 2004, Biomaterials.

[67]  A. Gupta,et al.  Hydrogel pullulan nanoparticles encapsulating pBUDLacZ plasmid as an efficient gene delivery carrier. , 2004, Journal of controlled release : official journal of the Controlled Release Society.

[68]  S. Xiong,et al.  Intranasal delivery of chitosan-DNA vaccine generates mucosal SIgA and anti-CVB3 protection. , 2004, Vaccine.

[69]  H E Junginger,et al.  Trimethylated chitosan as polymeric absorption enhancer for improved peroral delivery of peptide drugs. , 2004, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[70]  P. Hubert,et al.  Hydrophobically modified alginate hydrogels as protein carriers with specific controlled release properties. , 2004, Journal of controlled release : official journal of the Controlled Release Society.

[71]  A. Poso,et al.  Drug release from starch-acetate microparticles and films with and without incorporated alpha-amylase. , 2004, Biomaterials.

[72]  K. Akiyoshi,et al.  Single molecular mechanics of a cholesterol-bearing pullulan nanogel at the hydrophobic interfaces. , 2004, Biomaterials.

[73]  C. van Nostrum,et al.  Biodegradable dextran hydrogels crosslinked by stereocomplex formation for the controlled release of pharmaceutical proteins. , 2004, International journal of pharmaceutics.

[74]  A. Bernkop‐Schnürch,et al.  Thiolated chitosans: development and in vitro evaluation of a mucoadhesive, permeation enhancing oral drug delivery system. , 2004, Journal of controlled release : official journal of the Controlled Release Society.

[75]  J. Mano,et al.  Chitosan-Based Particles as Controlled Drug Delivery Systems , 2004, Drug delivery.

[76]  M. K. Chourasia,et al.  Polysaccharides for Colon Targeted Drug Delivery , 2004, Drug delivery.

[77]  A. Bernkop‐Schnürch,et al.  Permeation enhancing polymers in oral delivery of hydrophilic macromolecules: thiomer/GSH systems. , 2003, Journal of controlled release : official journal of the Controlled Release Society.

[78]  M. Lacroix,et al.  N-acylated chitosan: hydrophobic matrices for controlled drug release. , 2003, Journal of controlled release : official journal of the Controlled Release Society.

[79]  J. de Braekeleer,et al.  Generation of Toxoplasma gondii GRA1 protein and DNA vaccine loaded chitosan particles: preparation, characterization, and preliminary in vivo studies. , 2003, International journal of pharmaceutics.

[80]  Mansoor Amiji,et al.  Chitosan-based gastrointestinal delivery systems. , 2003, Journal of controlled release : official journal of the Controlled Release Society.

[81]  H. Junginger,et al.  Chitosan microparticles for mucosal vaccination against diphtheria: oral and nasal efficacy studies in mice. , 2003, Vaccine.

[82]  Eun Seong Lee,et al.  Adriamycin loaded pullulan acetate/sulfonamide conjugate nanoparticles responding to tumor pH: pH-dependent cell interaction, internalization and cytotoxicity in vitro. , 2003, Journal of controlled release : official journal of the Controlled Release Society.

[83]  A. Bernkop‐Schnürch,et al.  In vitro evaluation of polymeric excipients protecting calcitonin against degradation by intestinal serine proteases. , 2003, International journal of pharmaceutics.

[84]  Yumin Du,et al.  Effect of molecular structure of chitosan on protein delivery properties of chitosan nanoparticles. , 2003, International journal of pharmaceutics.

[85]  Tsutomu Suzuki,et al.  Chitosan capsules for colon-specific drug delivery: enhanced localization of 5-aminosalicylic acid in the large intestine accelerates healing of TNBS-induced colitis in rats. , 2002, Journal of controlled release : official journal of the Controlled Release Society.

[86]  G. Hardee,et al.  Characterization of alginate/poly-L-lysine particles as antisense oligonucleotide carriers. , 2002, International journal of pharmaceutics.

[87]  Kazushi Fujimoto,et al.  Hierarchical Self-Assembly of Hydrophobically Modified Pullulan in Water: Gelation by Networks of Nanoparticles , 2002 .

[88]  H. Tønnesen,et al.  Alginate in Drug Delivery Systems , 2002, Drug development and industrial pharmacy.

[89]  H E Junginger,et al.  Chitosan for mucosal vaccination. , 2001, Advanced drug delivery reviews.

[90]  I. Kwon,et al.  Structural characteristics of size-controlled self-aggregates of deoxycholic acid-modified chitosan and their application as a DNA delivery carrier. , 2001, Bioconjugate chemistry.

[91]  A. Maitra,et al.  Tumour targeted delivery of encapsulated dextran-doxorubicin conjugate using chitosan nanoparticles as carrier. , 2001, Journal of controlled release : official journal of the Controlled Release Society.

[92]  M. Taha,et al.  Synthesis of iron-crosslinked chitosan succinate and iron-crosslinked hydroxamated chitosan succinate and their in vitro evaluation as potential matrix materials for oral theophylline sustained-release beads. , 2001, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[93]  H E Junginger,et al.  Chitosan microparticles for oral vaccination: preparation, characterization and preliminary in vivo uptake studies in murine Peyer's patches. , 2001, Biomaterials.

[94]  K. Janes,et al.  Polysaccharide colloidal particles as delivery systems for macromolecules. , 2001, Advanced drug delivery reviews.

[95]  H E Junginger,et al.  In Vivo Uptake of Chitosan Microparticles by Murine Peyer's Patches: Visualization Studies using Confocal Laser Scanning Microscopy and Immunohistochemistry , 2001, Journal of drug targeting.

[96]  P. Wertz,et al.  Enhancing effect of chitosan on peptide drug delivery across buccal mucosa. , 2000, Biomaterials.

[97]  Caldwell,et al.  Mucin Adsorption to Hydrophobic Surfaces. , 2000, Journal of colloid and interface science.

[98]  C. Sharma,et al.  Beta cyclodextrin-insulin-encapsulated chitosan/alginate matrix : Oral delivery system , 2000 .

[99]  P. Couvreur,et al.  Insulin‐loaded nanocapsules for oral administration: In vitro and in vivo investigation , 2000 .

[100]  H. Ichikawa,et al.  Chitosan-Gadopentetic Acid Complex Nanoparticles for Gadolinium Neutron-Capture Therapy of Cancer: Preparation by Novel Emulsion-Droplet Coalescence Technique and Characterization , 1999, Pharmaceutical Research.

[101]  T. Fujinaga,et al.  Accelerating effects of chitosan for healing at early phase of experimental open wound in dogs. , 1999, Biomaterials.

[102]  L. Yang,et al.  A new intragastric delivery system for the treatment of Helicobacter pylori associated gastric ulcer: in vitro evaluation. , 1999, Journal of controlled release : official journal of the Controlled Release Society.

[103]  T. Fujita,et al.  Colon-specific delivery of R68070, a new thromboxane synthase inhibitor, using chitosan capsules: therapeutic effects against 2,4,6-trinitrobenzene sulfonic acid-induced ulcerative colitis in rats. , 1999, Life sciences.

[104]  R. Mumper,et al.  Chitosan and depolymerized chitosan oligomers as condensing carriers for in vivo plasmid delivery. , 1998, Journal of controlled release : official journal of the Controlled Release Society.

[105]  P Buri,et al.  Chitosan: a unique polysaccharide for drug delivery. , 1998, Drug development and industrial pharmacy.

[106]  L. Illum,et al.  Chitosan and its use as a pharmaceutical excipient. , 1998, Pharmaceutical research.

[107]  S. W. Kim,et al.  Self-assembled hydrogel nanoparticle of cholesterol-bearing pullulan as a carrier of protein drugs: complexation and stabilization of insulin. , 1998, Journal of controlled release : official journal of the Controlled Release Society.

[108]  Wayne R. Gombotz,et al.  Protein release from alginate matrices. , 1998, Advanced drug delivery reviews.

[109]  W. Hennink,et al.  Dextran hydrogels for the controlled release of proteins , 1997 .

[110]  S. Tokura,et al.  Effects of chitin and its derivatives on the proliferation and cytokine production of fibroblasts in vitro. , 1997, Biomaterials.

[111]  H. Junginger,et al.  Mucoadhesive polymers in peroral peptide drug delivery. IV. Polycarbophil and chitosan are potent enhancers of peptide transport across intestinal mucosae in vitro , 1997 .

[112]  T. Maruyama,et al.  Chitosan capsules for colon-specific drug delivery: improvement of insulin absorption from the rat colon. , 1996, Journal of pharmaceutical sciences.

[113]  Mansoor M. Amiji,et al.  Preparation and Characterization of Freeze-dried Chitosan-Poly(Ethylene Oxide) Hydrogels for Site-Specific Antibiotic Delivery in the Stomach , 1996, Pharmaceutical Research.

[114]  H. Brøndsted,et al.  Dextran hydrogels for colon-specific drug delivery. V. Degradation in human intestinal incubation models , 1995 .

[115]  E. Schacht,et al.  Alginates as drug carriers: covalent attachment of alginates to therapeutic agents containing primary amine groups , 1995 .

[116]  L. Rubin,et al.  Evidence that tyrosine phosphorylation may increase tight junction permeability. , 1995, Journal of cell science.

[117]  Takehiro Nishikawa,et al.  Supramolecular Assembly between Nanoparticles of Hydrophobized Polysaccharide and Soluble Protein Complexation between the Self-Aggregate of Cholesterol-Bearing Pullulan and .alpha.-Chymotrypsin , 1994 .

[118]  Lisbeth Illum,et al.  Effect of Chitosan on the Permeability of Monolayers of Intestinal Epithelial Cells (Caco-2) , 1994, Pharmaceutical Research.

[119]  Toshiharu Horie,et al.  Enhancement of Colonic Drug Absorption by the Transcellular Permeation Route , 1988, Pharmaceutical Research.

[120]  T. Nagai,et al.  Directly compressed tablets containing chitin or chitosan in addition to lactose or potato starch. , 1982, Chemical & pharmaceutical bulletin.

[121]  M. Rekha,et al.  Hemocompatible pullulan-polyethyleneimine conjugates for liver cell gene delivery: In vitro evaluation of cellular uptake, intracellular trafficking and transfection efficiency. , 2011, Acta biomaterialia.

[122]  Gerrit Borchard,et al.  Progress in chitosan-based vaccine delivery systems , 2010 .

[123]  Yu-Hsin Lin,et al.  Preparation and characterization of nanoparticles shelled with chitosan for oral insulin delivery. , 2007, Biomacromolecules.

[124]  S. Rossi,et al.  Nanoparticles based on N-trimethylchitosan: evaluation of absorption properties using in vitro (Caco-2 cells) and ex vivo (excised rat jejunum) models. , 2007, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[125]  V. Labhasetwar,et al.  Nanosystems in Drug Targeting: Opportunities and Challenges , 2005 .

[126]  G. Barratt,et al.  Colloidal drug carriers: achievements and perspectives , 2003, Cellular and Molecular Life Sciences CMLS.

[127]  C. Sharma,et al.  Lipoinsulin encapsulated alginate-chitosan capsules: intestinal delivery in diabetic rats , 2000, Journal of microencapsulation.

[128]  G. Mahrous,et al.  Preparation and evaluation of sustained release cross-linked chitosan microspheres containing phenobarbitone. , 1998, Journal of microencapsulation.

[129]  Y. Shigemasa,et al.  Applications of chitin and chitosan for biomaterials. , 1996, Biotechnology & genetic engineering reviews.

[130]  A. Moes Gastroretentive dosage forms. , 1993, Critical reviews in therapeutic drug carrier systems.

[131]  J. Mano,et al.  hitosan derivatives obtained by chemical modifications for biomedical nd environmental applications , 2022 .