FOXO3 signalling links ATM to the p53 apoptotic pathway following DNA damage

[1]  Ophelia S. Venturelli,et al.  The pro-longevity gene FoxO3 is a direct target of the p53 tumor suppressor , 2011, Oncogene.

[2]  F. Zunino,et al.  ATM- and ATR-mediated response to DNA damage induced by a novel camptothecin, ST1968. , 2010, Cancer letters.

[3]  William Arbuthnot Sir Lane,et al.  ATM activates p53 by regulating MDM2 oligomerization and E3 processivity , 2009, The EMBO journal.

[4]  K. Sakamoto,et al.  P53 negatively regulates the transcriptional activity of FOXO3a under oxidative stress , 2009, Cell biology international.

[5]  Pengfei Li,et al.  MDM2 Acts Downstream of p53 as an E3 Ligase to Promote FOXO Ubiquitination and Degradation* , 2009, Journal of Biological Chemistry.

[6]  Stefan Schreiber,et al.  Association of FOXO3A variation with human longevity confirmed in German centenarians , 2009, Proceedings of the National Academy of Sciences.

[7]  T. Mak,et al.  Biochemical and structural characterization of an intramolecular interaction in FOXO3a and its binding with p53. , 2008, Journal of molecular biology.

[8]  Katsuhiko Yano,et al.  FOXO3A genotype is strongly associated with human longevity , 2008, Proceedings of the National Academy of Sciences.

[9]  Sathish Kumar Mungamuri,et al.  Foxo3 Is Essential for the Regulation of Ataxia Telangiectasia Mutated and Oxidative Stress-mediated Homeostasis of Hematopoietic Stem Cells* , 2008, Journal of Biological Chemistry.

[10]  G. Mills,et al.  ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation , 2008, Nature Cell Biology.

[11]  David J. Chen,et al.  Ku recruits XLF to DNA double‐strand breaks , 2008, EMBO reports.

[12]  T. Paull,et al.  Activation and regulation of ATM kinase activity in response to DNA double-strand breaks , 2007, Oncogene.

[13]  H. Nakauchi,et al.  Foxo3a is essential for maintenance of the hematopoietic stem cell pool. , 2007, Cell stem cell.

[14]  Burkhard Jakob,et al.  Autophosphorylation of DNA-PKCS regulates its dynamics at DNA double-strand breaks , 2007, The Journal of cell biology.

[15]  T. Hofmann,et al.  Homeodomain-interacting protein kinase 2 is the ionizing radiation-activated p53 serine 46 kinase and is regulated by ATM. , 2007, Cancer research.

[16]  Yonghong Xiao,et al.  FoxOs Are Lineage-Restricted Redundant Tumor Suppressors and Regulate Endothelial Cell Homeostasis , 2007, Cell.

[17]  Wei Zhang,et al.  Transcriptional activation of the carboxylesterase 2 gene by the p53 pathway , 2006, Cancer biology & therapy.

[18]  Y. Pommier,et al.  Defective Mre11-dependent Activation of Chk2 by Ataxia Telangiectasia Mutated in Colorectal Carcinoma Cells in Response to Replication-dependent DNA Double Strand Breaks* , 2006, Journal of Biological Chemistry.

[19]  T. Mak,et al.  Regulation of transactivation-independent proapoptotic activity of p53 by FOXO3a. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[20]  S. Ichwan,et al.  Defect in serine 46 phosphorylation of p53 contributes to acquisition of p53 resistance in oral squamous cell carcinoma cells , 2006, Oncogene.

[21]  R. Coombes,et al.  Paclitaxel-induced nuclear translocation of FOXO3a in breast cancer cells is mediated by c-Jun NH2-terminal kinase and Akt. , 2006, Cancer research.

[22]  E. Greer,et al.  FOXO transcription factors at the interface between longevity and tumor suppression , 2005, Oncogene.

[23]  N. Motoyama,et al.  FOXO transcription factors in cell-cycle regulation and the response to oxidative stress. , 2005, Antioxidants & redox signaling.

[24]  Ji-Hoon Lee,et al.  ATM Activation by DNA Double-Strand Breaks Through the Mre11-Rad50-Nbs1 Complex , 2005, Science.

[25]  S. Nemoto,et al.  Nutrient Availability Regulates SIRT1 Through a Forkhead-Dependent Pathway , 2004, Science.

[26]  Jiri Bartek,et al.  Cell-cycle checkpoints and cancer , 2004, Nature.

[27]  T. Mak,et al.  p53-dependent inhibition of FKHRL1 in response to DNA damage through protein kinase SGK1. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[28]  S. Anderson,et al.  Integration of Smad and Forkhead Pathways in the Control of Neuroepithelial and Glioblastoma Cell Proliferation , 2004, Cell.

[29]  Ryuji Kobayashi,et al.  IκB Kinase Promotes Tumorigenesis through Inhibition of Forkhead FOXO3a , 2004, Cell.

[30]  J. Bartek,et al.  Distinct functional domains of Nbs1 modulate the timing and magnitude of ATM activation after low doses of ionizing radiation , 2004, Oncogene.

[31]  Ji-Hoon Lee,et al.  Direct Activation of the ATM Protein Kinase by the Mre11/Rad50/Nbs1 Complex , 2004, Science.

[32]  Yair Andegeko,et al.  Requirement of the MRN complex for ATM activation by DNA damage , 2003, The EMBO journal.

[33]  Jiri Bartek,et al.  Chk1 and Chk2 kinases in checkpoint control and cancer. , 2003, Cancer cell.

[34]  Y. Shiloh ATM and related protein kinases: safeguarding genome integrity , 2003, Nature Reviews Cancer.

[35]  M. Kastan,et al.  DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation , 2003, Nature.

[36]  S. R. Datta,et al.  DNA Repair Pathway Stimulated by the Forkhead Transcription Factor FOXO3a Through the Gadd45 Protein , 2002, Science.

[37]  Yoichi Taya,et al.  Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2 , 2002, Nature Cell Biology.

[38]  Giulia Piaggio,et al.  Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis , 2002, Nature Cell Biology.

[39]  C. Martínez-A,et al.  Forkhead transcription factors contribute to execution of the mitotic programme in mammals , 2001, Nature.

[40]  Y. Shiloh,et al.  Nuclear retention of ATM at sites of DNA double strand breaks. , 2001, The Journal of biological chemistry.

[41]  E. Appella,et al.  Post-translational modifications and activation of p53 by genotoxic stresses. , 2001, European journal of biochemistry.

[42]  S. T. Kim,et al.  ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage. , 2001, Genes & development.

[43]  Yusuke Nakamura,et al.  p53AIP1, a Potential Mediator of p53-Dependent Apoptosis, and Its Regulation by Ser-46-Phosphorylated p53 , 2000, Cell.

[44]  Y. Shiloh,et al.  Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[45]  E. Stavridi,et al.  Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[46]  P. Howley,et al.  Mutations in serines 15 and 20 of human p53 impair its apoptotic activity , 1999, Oncogene.

[47]  M. Greenberg,et al.  Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor , 1999, Cell.

[48]  C. Prives,et al.  The p53 pathway , 1999, The Journal of pathology.

[49]  P. Billings,et al.  Molecular and biochemical mechanisms of Pasteurella haemolytica leukotoxin-induced cell death. , 1998, Microbial pathogenesis.

[50]  A. Giaccia,et al.  The complexity of p53 modulation: emerging patterns from divergent signals. , 1998, Genes & development.

[51]  Y Taya,et al.  Enhanced phosphorylation of p53 by ATM in response to DNA damage. , 1998, Science.

[52]  Yoichi Taya,et al.  DNA Damage-Induced Phosphorylation of p53 Alleviates Inhibition by MDM2 , 1997, Cell.

[53]  M. Oren,et al.  Mdm2 promotes the rapid degradation of p53 , 1997, Nature.

[54]  C. Holden,et al.  Death Star , 1995, Science.

[55]  D. Lane,et al.  p53, guardian of the genome , 1992, Nature.

[56]  Robert Walgate,et al.  Proliferation , 1985, Nature.