Heart rate informed artificial pancreas system enhances glycemic control during exercise in adolescents with T1D

To evaluate the safety and performance of using a heart rate (HR) monitor to inform an artificial pancreas (AP) system during exercise among adolescents with type 1 diabetes (T1D).

[1]  D. BretonMarc,et al.  Adding heart rate signal to a control-to-range artificial pancreas system improves the protection against hypoglycemia during exercise in type 1 diabetes. , 2014 .

[2]  Y. Z. Ider,et al.  Quantitative estimation of insulin sensitivity. , 1979, The American journal of physiology.

[3]  Marc D Breton,et al.  Adding heart rate signal to a control-to-range artificial pancreas system improves the protection against hypoglycemia during exercise in type 1 diabetes. , 2014, Diabetes technology & therapeutics.

[4]  Eyal Dassau,et al.  Control to Range for Diabetes: Functionality and Modular Architecture , 2009, Journal of diabetes science and technology.

[5]  S. Davis,et al.  Exercise-related hypoglycemia in diabetes mellitus , 2011, Expert review of endocrinology & metabolism.

[6]  G. Steil,et al.  Effect of Age of Infusion Site and Type of Rapid-Acting Analog on Pharmacodynamic Parameters of Insulin Boluses in Youth With Type 1 Diabetes Receiving Insulin Pump Therapy , 2009, Diabetes Care.

[7]  B. Buckingham,et al.  Day-and-Night Closed-Loop Control Using the Unified Safety System in Adolescents With Type 1 Diabetes at Camp , 2016, Diabetes Care.

[8]  B. Kovatchev,et al.  Use of an artificial pancreas among adolescents for a missed snack bolus and an underestimated meal bolus , 2016, Pediatric diabetes.

[9]  Howard C. Zisser,et al.  Feasibility of Outpatient Fully Integrated Closed-Loop Control , 2013, Diabetes Care.

[10]  G. Dohm.  Invited review: Regulation of skeletal muscle GLUT-4 expression by exercise. , 2002, Journal of applied physiology.

[11]  Eyal Dassau,et al.  Zone Model Predictive Control: A Strategy to Minimize Hyper- and Hypoglycemic Events , 2010, Journal of diabetes science and technology.

[12]  Kellee M Miller,et al.  The T1D Exchange clinic registry. , 2012, The Journal of clinical endocrinology and metabolism.

[13]  Ahmad Haidar,et al.  Closed-Loop Basal Insulin Delivery Over 36 Hours in Adolescents With Type 1 Diabetes , 2013, Diabetes Care.

[14]  Howard C. Zisser,et al.  Fully Integrated Artificial Pancreas in Type 1 Diabetes , 2012, Diabetes.

[15]  Marc D. Breton,et al.  Safety of Outpatient Closed-Loop Control: First Randomized Crossover Trials of a Wearable Artificial Pancreas , 2014, Diabetes Care.

[16]  Multinight "bedside" closed-loop control for patients with type 1 diabetes. , 2015, Diabetes technology & therapeutics.

[17]  T. Jones,et al.  Glucose requirements to maintain euglycemia after moderate-intensity afternoon exercise in adolescents with type 1 diabetes are increased in a biphasic manner. , 2007, The Journal of clinical endocrinology and metabolism.

[18]  R. Beck,et al.  A contrast between children and adolescents with excellent and poor control: the T1D exchange clinic registry experience , 2014, Pediatric diabetes.

[19]  J. Rausch,et al.  Predictors of deteriorations in diabetes management and control in adolescents with type 1 diabetes. , 2013, The Journal of adolescent health : official publication of the Society for Adolescent Medicine.

[20]  M. Walker,et al.  Insulin therapy and dietary adjustments to normalize glycemia and prevent nocturnal hypoglycemia after evening exercise in type 1 diabetes: a randomized controlled trial , 2015, BMJ Open Diabetes Research and Care.

[21]  N. Crimmins,et al.  Blood glucose monitoring and glycemic control in adolescents with type 1 diabetes: meter downloads versus self‐report , 2011, Pediatric diabetes.

[22]  L. Goodyear,et al.  Exercise, glucose transport, and insulin sensitivity. , 1998, Annual review of medicine.

[23]  Marc D Breton,et al.  Identification of Main Factors Explaining Glucose Dynamics During and Immediately After Moderate Exercise in Patients With Type 1 Diabetes , 2015, Journal of diabetes science and technology.

[24]  Stephen D Patek,et al.  Hypoglycemia Prevention via Pump Attenuation and Red-Yellow-Green “Traffic” Lights Using Continuous Glucose Monitoring and Insulin Pump Data , 2010, Journal of diabetes science and technology.

[25]  M. Riddell,et al.  Current perspectives on physical activity and exercise for youth with diabetes , 2015, Pediatric diabetes.

[26]  Marc D. Breton,et al.  Overnight Glucose Control With an Automated, Unified Safety System in Children and Adolescents With Type 1 Diabetes at Diabetes Camp , 2014, Diabetes Care.

[27]  D. BretonMarc,et al.  Multinight "bedside" closed-loop control for patients with type 1 diabetes. , 2015 .

[28]  C. Cobelli,et al.  In Silico Preclinical Trials: A Proof of Concept in Closed-Loop Control of Type 1 Diabetes , 2009, Journal of diabetes science and technology.