High prevalence of syphilis, HBV, and HCV co‐infection, and low rate of effective vaccination against hepatitis B in HIV‐infected patients in West China hospital

To investigate the epidemiological features and risk factors of HBV, HCV, and syphilis infection among HIV‐infected patients in West China Hospital. A retrospective study was conducted with HIV‐infected patients from 2014 to 2016 in West China hospital, SCU. Serum makers for HBV, HCV, and syphilis were detected. Among 894 HIV‐infected patients, the prevalence of HIV/HBV, HIV/HCV, HIV/syphilis co‐infections was 14.4%, 5.7%, and 18.9% respectively. HIV/HBV/HCV, HIV/HCV/syphilis, and HIV/HBV/syphilis triple co‐infection was 7 (0.7%), 12(1.3%), 29(3.2%) respectively. The rate of effective vaccination against HBV was only 7.7% in HIV‐infected patients. Age (OR = 0.243 95% CI: 0.114 −0.518), ethnicity (OR = 3.654 95% CI: 1.849‐7.218) and education level (OR = 0.140 95% CI: 0.033‐0.606) are risk factors affecting HIV/HCV co‐infection. A high prevalence of HIV/syphilis, HIV/HBV, and HIV/ HCV co‐infection can be observed in west China. The rate for HIV‐infected patients who were effectively vaccinated against HBV was fewer than 10%.

[1]  Tianfei Yang,et al.  Epidemiological profile and risk factors of HIV and HBV/HCV co‐infection in Fujian Province, southeastern China , 2017, Journal of medical virology.

[2]  A. Litwin,et al.  Correlates of Hepatitis C Virus Infection in the Targeted Testing Program of the New York City Jail System , 2017, Public health reports.

[3]  A. Mirzazadeh,et al.  HIV, HBV and HCV Coinfection Prevalence in Iran - A Systematic Review and Meta-Analysis , 2016, PloS one.

[4]  J. Al-Mughales Co‐infection assessment in HBV, HCV, and HIV patients in Western Saudi Arabia , 2016, Journal of medical virology.

[5]  C. Thio,et al.  Prevalence of hepatitis B and C viruses in HIV-positive patients in China: a cross-sectional study , 2016, Journal of the International AIDS Society.

[6]  F. Voller,et al.  Prevalence and characteristics of HIV/HBV and HIV/HCV coinfections in Tuscany , 2015, The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases.

[7]  H. Jessen,et al.  High Prevalence and High Incidence of Coinfection with Hepatitis B, Hepatitis C, and Syphilis and Low Rate of Effective Vaccination against Hepatitis B in HIV-Positive Men Who Have Sex with Men with Known Date of HIV Seroconversion in Germany , 2015, PloS one.

[8]  Z. Qiu,et al.  Seroprevalence of the Hepatitis B, Hepatitis C, and Human Immunodeficiency Viruses and Treponema pallidum at the Beijing General Hospital from 2010 to 2014: A Cross-Sectional Study , 2015, PloS one.

[9]  M. Lusida,et al.  Viral hepatitis and human immunodeficiency virus co-infections in Asia. , 2015, World journal of virology.

[10]  A. Farfán-García,et al.  Epidemiology, Risk Factors and Genotypes of HBV in HIV-Infected Patients in the Northeast Region of Colombia: High Prevalence of Occult Hepatitis B and F3 Subgenotype Dominance , 2014, PloS one.

[11]  Jing Liu,et al.  HIV, hepatitis B virus, and hepatitis C virus co-infection in patients in the China National Free Antiretroviral Treatment Program, 2010-12: a retrospective observational cohort study. , 2014, The Lancet. Infectious diseases.

[12]  J. Jia,et al.  Update on epidemiology of hepatitis B and C in China , 2013, Journal of gastroenterology and hepatology.

[13]  M. Salminen,et al.  Infection with hepatitis B and C virus in Europe: a systematic review of prevalence and cost-effectiveness of screening , 2013, BMC Infectious Diseases.

[14]  Xi Chen,et al.  Prevalence of hepatitis B virus and hepatitis C virus in patients with human immunodeficiency virus infection in central China , 2013, Archives of Virology.

[15]  A. Flaxman,et al.  Global epidemiology of hepatitis C virus infection: New estimates of age‐specific antibody to HCV seroprevalence , 2013, Hepatology.

[16]  Li Li,et al.  Reprint of: Epidemiological serosurvey of Hepatitis B in China--declining HBV prevalence due to Hepatitis B vaccination. , 2013, Vaccine.

[17]  Nancy Glass,et al.  Global burden of hepatitis C: considerations for healthcare providers in the United States. , 2012, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[18]  D. Jamieson,et al.  HIV-HBV coinfection--a global challenge. , 2012, The New England journal of medicine.

[19]  Louisa Degenhardt,et al.  Global epidemiology of hepatitis B and hepatitis C in people who inject drugs: results of systematic reviews , 2011, The Lancet.

[20]  F. Sanai,et al.  A systematic review of hepatitis C virus epidemiology in Asia, Australia and Egypt , 2011, Liver international : official journal of the International Association for the Study of the Liver.

[21]  B. Gazzard,et al.  Increasing burden of liver disease in patients with HIV infection , 2011, The Lancet.

[22]  V. Sharp,et al.  Co-infection of hepatitis B and hepatitis C virus in human immunodeficiency virus-infected patients in New York City, United States. , 2008, World journal of gastroenterology.

[23]  M. Alter,et al.  Epidemiology of viral hepatitis and HIV co-infection. , 2006, Journal of hepatology.

[24]  A. Mocroft,et al.  Hepatitis B and HIV: prevalence, AIDS progression, response to highly active antiretroviral therapy and increased mortality in the EuroSIDA cohort , 2005, AIDS.

[25]  R. Peeling,et al.  Syphilis control--a continuing challenge. , 2004, The New England journal of medicine.

[26]  Brian L. Pearlman,et al.  Hepatitis C Infection: A Clinical Review , 2004, Southern medical journal.