A read-across case study on chronic toxicity of branched carboxylic acids (1): Integration of mechanistic evidence from new approach methodologies (NAMs) to explore a common mode of action.
暂无分享,去创建一个
Thomas E. Exner | E. Benfenati | O. Taboureau | B. van de Water | E. Mombelli | A. Limonciel | P. Jennings | T. Braunbeck | B. van der Burg | T. Exner | B. V. van Vugt-Lussenburg | U. Norinder | C. Fisher | R. Graepel | I. Gardner | Domenico Gadaleta | Barbara Zdrazil | S. Escher | L. Tolosa | O. Hatley | A. Long | Alejandro Aguayo-Orozco | Sankalp Jain | A. White | P. Walker | Katharina Brotzmann | R. Maclennan | A. Bitsch | N. Vrijenhoek | L. Capinha | Daria Goldmann | A. Aguayo-Orozco | N. Golbamaki | F. Bois | Matthias Wehr | Jose Castel | Oliver Hatley | Frédéric Y. Bois
[1] A. Moschetta,et al. Transcriptional Regulation of Metabolic Pathways via Lipid-Sensing Nuclear Receptors PPARs, FXR, and LXR in NASH , 2021, Cellular and molecular gastroenterology and hepatology.
[2] Eann A. Patterson,et al. The role of validation in establishing the scientific credibility of predictive toxicology approaches intended for regulatory application , 2021, Computational toxicology.
[3] M. Cronin,et al. Incorporating Lines of Evidence from New Approach Methodologies (NAMs) to Reduce Uncertainties in a Category Based Read-Across: A Case Study for Repeated Dose Toxicity. , 2020, Regulatory toxicology and pharmacology : RTP.
[4] Barbara Zdrazil,et al. Towards grouping concepts based on new approach methodologies in chemical hazard assessment: the read-across approach of the EU-ToxRisk project , 2019, Archives of Toxicology.
[5] Ioannis Sadiktsis,et al. Abstracts of the 55th Congress of the European Societies of Toxicology (EUROTOX 2019) TOXICOLOGY SCIENCE PROVIDING SOLUTIONS , 2019, Toxicology Letters.
[6] Olivier Taboureau,et al. sAOP: linking chemical stressors to adverse outcomes pathway networks , 2019, Bioinform..
[7] D. Verloo,et al. Food Safety Regulatory Research Needs 2030 , 2019, EFSA journal. European Food Safety Authority.
[8] Thomas C. Wiegers,et al. The Comparative Toxicogenomics Database: update 2019 , 2018, Nucleic Acids Res..
[9] S. Brunak,et al. Analysis of Time-Series Gene Expression Data to Explore Mechanisms of Chemical-Induced Hepatic Steatosis Toxicity , 2018, Front. Genet..
[10] Marcus J. Tindall,et al. Multi-scale, whole-system models of liver metabolic adaptation to fat and sugar in non-alcoholic fatty liver disease , 2018, npj Systems Biology and Applications.
[11] Imran Shah,et al. Navigating through the minefield of read-across frameworks: A commentary perspective , 2018 .
[12] Chihae Yang,et al. Dempster-Shafer theory for combining in silico evidence and estimating uncertainty in chemical risk assessment , 2018 .
[13] Skylar W. Marvel,et al. ToxPi Graphical User Interface 2.0: Dynamic exploration, visualization, and sharing of integrated data models , 2018, BMC Bioinformatics.
[14] Bob van de Water,et al. Dynamic imaging of adaptive stress response pathway activation for prediction of drug induced liver injury , 2018, Archives of Toxicology.
[15] Brian E. Howard,et al. A hybrid gene selection approach to create the S1500+ targeted gene sets for use in high-throughput transcriptomics , 2018, PloS one.
[16] J. Kleinjans,et al. Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. , 2018, Toxicology.
[17] Terry W Schultz,et al. Lessons learned from read-across case studies for repeated-dose toxicity. , 2017, Regulatory toxicology and pharmacology : RTP.
[18] R. Judson,et al. Systematically evaluating read-across prediction and performance using a local validity approach characterized by chemical structure and bioactivity information. , 2016, Regulatory toxicology and pharmacology : RTP.
[19] Bob van de Water,et al. High-content imaging-based BAC-GFP toxicity pathway reporters to assess chemical adversity liabilities , 2016, Archives of Toxicology.
[20] M. Ingelman-Sundberg,et al. Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease , 2016, Scientific Reports.
[21] Alexandra Maertens,et al. t4 report: Toward Good Read-Across Practice (GRAP) Guidance , 2016, ALTEX.
[22] E. Kroese,et al. t4 report , 2016, ALTEX.
[23] Fabian P. Steinmetz,et al. The identification of nuclear receptors associated with hepatic steatosis to develop and extend adverse outcome pathways , 2016, Critical reviews in toxicology.
[24] G. Guo,et al. Mechanistic review of drug-induced steatohepatitis. , 2015, Toxicology and applied pharmacology.
[25] Philippe Lefebvre,et al. Molecular mechanism of PPARα action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease. , 2015, Journal of hepatology.
[26] R. Stierum,et al. Toxicogenomics directory of chemically exposed human hepatocytes , 2014, Archives of Toxicology.
[27] Hiroshi Yamada,et al. Open TG-GATEs: a large-scale toxicogenomics database , 2014, Nucleic Acids Res..
[28] J. Castell,et al. High-content screening of drug-induced mitochondrial impairment in hepatic cells: effects of statins , 2014, Archives of Toxicology.
[29] A. Elmarakby,et al. Valproate-Induced Liver Injury: Modulation by the Omega-3 Fatty Acid DHA Proposes a Novel Anticonvulsant Regimen , 2014, Drugs in R&D.
[30] Karen Blackburn,et al. A framework to facilitate consistent characterization of read across uncertainty. , 2014, Regulatory toxicology and pharmacology : RTP.
[31] L. Cao,et al. Combined effects of a high-fat diet and chronic valproic acid treatment on hepatic steatosis and hepatotoxicity in rats , 2014, Acta Pharmacologica Sinica.
[32] I. Rusyn,et al. Integrative chemical-biological read-across approach for chemical hazard classification. , 2013, Chemical research in toxicology.
[33] A. Limonciel,et al. Delineation of the Key Aspects in the Regulation of Epithelial Monolayer Formation , 2013, Molecular and Cellular Biology.
[34] S. Linden,et al. A Panel of Quantitative Calux® Reporter Gene Assays for Reliable High‐Throughput Toxicity Screening of Chemicals and Complex Mixtures , 2013 .
[35] Paul Jennings,et al. Oxidative stress induced by potassium bromate exposure results in altered tight junction protein expression in renal proximal tubule cells , 2012, Archives of Toxicology.
[36] W. Wahli,et al. PPARs at the crossroads of lipid signaling and inflammation , 2012, Trends in Endocrinology & Metabolism.
[37] Peter S. Kutchukian,et al. Rethinking molecular similarity: comparing compounds on the basis of biological activity. , 2012, ACS chemical biology.
[38] Agustín Lahoz,et al. Development of a multiparametric cell-based protocol to screen and classify the hepatotoxicity potential of drugs. , 2012, Toxicological sciences : an official journal of the Society of Toxicology.
[39] Hilda Witters,et al. Zebrafish embryos as an alternative to animal experiments--a commentary on the definition of the onset of protected life stages in animal welfare regulations. , 2012, Reproductive toxicology.
[40] M. T. Donato,et al. High-Content Imaging Technology for the Evaluation of Drug-Induced Steatosis Using a Multiparametric Cell-Based Assay , 2012, Journal of biomolecular screening.
[41] Paul Jennings,et al. Lactate is an ideal non-invasive marker for evaluating temporal alterations in cell stress and toxicity in repeat dose testing regimes. , 2011, Toxicology in vitro : an international journal published in association with BIBRA.
[42] I. T. de Almeida,et al. Inhibition of hepatic carnitine palmitoyl-transferase I (CPT IA) by valproyl-CoA as a possible mechanism of valproate-induced steatosis. , 2010, Biochemical pharmacology.
[43] R. Bunte,et al. Evaluation of rapid cooling and tricaine methanesulfonate (MS222) as methods of euthanasia in zebrafish (Danio rerio). , 2009, Journal of the American Association for Laboratory Animal Science : JAALAS.
[44] Paul Jennings,et al. Inter-laboratory comparison of human renal proximal tubule (HK-2) transcriptome alterations due to Cyclosporine A exposure and medium exhaustion. , 2009, Toxicology in vitro : an international journal published in association with BIBRA.
[45] Paul Jennings,et al. hTERT alone immortalizes epithelial cells of renal proximal tubules without changing their functional characteristics. , 2008, American journal of physiology. Renal physiology.
[46] E. Herman,et al. Age‐related differences in susceptibility to toxic effects of valproic acid in rats , 2008, Journal of applied toxicology : JAT.
[47] Karl Mechtler,et al. BAC TransgeneOmics: a high-throughput method for exploration of protein function in mammals , 2008, Nature Methods.
[48] M. Duran,et al. Valproic acid metabolism and its effects on mitochondrial fatty acid oxidation: A review , 2008, Journal of Inherited Metabolic Disease.
[49] S. Krähenbühl,et al. Toxicity of Valproic Acid in Mice with Decreased Plasma and Tissue Carnitine Stores , 2008, Journal of Pharmacology and Experimental Therapeutics.
[50] Thomas K. H. Chang,et al. Oxidative Stress as a Mechanism of Valproic Acid-Associated Hepatotoxicity , 2006, Drug metabolism reviews.
[51] Thomas K. H. Chang,et al. Valproic acid I: time course of lipid peroxidation biomarkers, liver toxicity, and valproic acid metabolite levels in rats. , 2005, Toxicological sciences : an official journal of the Society of Toxicology.
[52] Valérie Zuang,et al. A Modular Approach to the ECVAM Principles on Test Validity , 2004, Alternatives to laboratory animals : ATLA.
[53] Johan Auwerx,et al. Activation of peroxisome proliferator-activated receptor δ induces fatty acid β-oxidation in skeletal muscle and attenuates metabolic syndrome , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[54] R. M. David,et al. 2-Ethylhexanoic acid: subchronic oral toxicity studies in the rat and mouse. , 1998, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
[55] W. Löscher,et al. Effects of valproate and E-2-en-valproate on functional and morphological parameters of rat liver. I. Biochemical, histopathological and pharmacokinetic studies , 1992, Epilepsy Research.
[56] Yohnosuke Kobayashi,et al. Hepatotoxicity in Rat Following Administration of Valproic Acid , 1987, Epilepsia.
[57] D. Turnbull,et al. Plasma concentrations of sodium valproate: Their clinical value , 1983, Annals of neurology.
[58] Azadi Golbamaki Bakhtyari,et al. Automated Integration of Structural, Biological and Metabolic Similarities to Improve Read-Across , 2020 .
[59] Imran Shah,et al. Generalized Read-Across (GenRA): A workflow implemented into the EPA CompTox Chemicals Dashboard. , 2019, ALTEX.
[60] A. Krebs. Template for the description of cell-based toxicological test methods to allow evaluation and regulatory use of the data_suppl , 2019, ALTEX.
[61] Ibrahim. Evaluation of Hepatotoxicity of Valproic acid in albino mice , Histological and Histoistochemical studies , 2022 .