Iron in multiple sclerosis: roles in neurodegeneration and repair
暂无分享,去创建一个
Jeff F. Dunn | Nabeela Nathoo | V. Wee Yong | J. Dunn | V. Yong | N. Nathoo | Erin Stephenson | Y. Mahjoub | Erin Stephenson | Yasamin Mahjoub | J. Dunn | V. Wee Yong
[1] Simon Hametner,et al. Multiple sclerosis deep grey matter: the relation between demyelination, neurodegeneration, inflammation and iron , 2014, Journal of Neurology, Neurosurgery & Psychiatry.
[2] Manuel A. Friese,et al. Mechanisms of neurodegeneration and axonal dysfunction in multiple sclerosis , 2014, Nature Reviews Neurology.
[3] H. Lassmann,et al. Oxidative tissue injury in multiple sclerosis is only partly reflected in experimental disease models , 2014, Acta Neuropathologica.
[4] A. Suttkus,et al. Aggrecan, link protein and tenascin-R are essential components of the perineuronal net to protect neurons against iron-induced oxidative stress , 2014, Cell Death and Disease.
[5] G. Harauz,et al. Hemoglobin as a source of iron overload in multiple sclerosis: does multiple sclerosis share risk factors with vascular disorders? , 2014, Cellular and Molecular Life Sciences.
[6] S. Lynch,et al. Iron chelation and multiple sclerosis , 2013, ASN neuro.
[7] R Marc Lebel,et al. Longitudinal MR imaging of iron in multiple sclerosis: an imaging marker of disease. , 2013, Radiology.
[8] J. Lefaucheur,et al. Iron depletion induced by bloodletting and followed by rhEPO administration as a therapeutic strategy in progressive multiple sclerosis: A pilot, open-label study with neurophysiological measurements , 2013, Neurophysiologie Clinique/Clinical Neurophysiology.
[9] W. Koppenol,et al. The complex interplay of iron metabolism, reactive oxygen species, and reactive nitrogen species: insights into the potential of various iron therapies to induce oxidative and nitrosative stress. , 2013, Free radical biology & medicine.
[10] D. McTigue,et al. Neonatal E. Coli Infection Causes Neuro-Behavioral Deficits Associated with Hypomyelination and Neuronal Sequestration of Iron , 2013, The Journal of Neuroscience.
[11] Simon Hametner,et al. Iron and neurodegeneration in the multiple sclerosis brain , 2013, Annals of neurology.
[12] V. Yong,et al. Pathophysiology of the brain extracellular matrix: a new target for remyelination , 2013, Nature Reviews Neuroscience.
[13] Saifeng Liu,et al. Measuring iron in the brain using quantitative susceptibility mapping and X-ray fluorescence imaging , 2013, NeuroImage.
[14] T. Kuhlmann,et al. Oligodendrocyte progenitor cell susceptibility to injury in multiple sclerosis. , 2013, The American journal of pathology.
[15] T. Rouault,et al. Iron metabolism in the CNS: implications for neurodegenerative diseases , 2013, Nature Reviews Neuroscience.
[16] Cris S Constantinescu,et al. Increased iron accumulation occurs in the earliest stages of demyelinating disease: an ultra-high field susceptibility mapping study in Clinically Isolated Syndrome , 2013, Multiple sclerosis.
[17] J. Dunn,et al. Susceptibility-weighted imaging in the experimental autoimmune encephalomyelitis model of multiple sclerosis indicates elevated deoxyhemoglobin, iron deposition and demyelination , 2013, Multiple sclerosis.
[18] R Marc Lebel,et al. Multiple sclerosis: validation of MR imaging for quantification and detection of iron. , 2013, Radiology.
[19] David Pitt,et al. Iron Is a Sensitive Biomarker for Inflammation in Multiple Sclerosis Lesions , 2013, PloS one.
[20] K. Nakanishi,et al. A highly-sulfated chondroitin sulfate, CS-E, adsorbs specifically to neurons with nuclear condensation , 2012, Neuroscience Research.
[21] B. Trapp,et al. Cortical remyelination: A new target for repair therapies in multiple sclerosis , 2012, Annals of neurology.
[22] Hans Lassmann,et al. Progressive multiple sclerosis: pathology and pathogenesis , 2012, Nature Reviews Neurology.
[23] Scott Sloka,et al. Chondroitin sulfate proteoglycans in demyelinated lesions impair remyelination , 2012, Annals of neurology.
[24] R. Eisenstein,et al. Mammalian iron metabolism and its control by iron regulatory proteins. , 2012, Biochimica et biophysica acta.
[25] T. Arendt,et al. Involvement of Perineuronal and Perisynaptic Extracellular Matrix in Alzheimer's Disease Neuropathology , 2012, Brain pathology.
[26] Xavier Golay,et al. Reduced R2′ in multiple sclerosis normal appearing white matter and lesions may reflect decreased myelin and iron content , 2012, Journal of Neurology, Neurosurgery & Psychiatry.
[27] A. Bar-Or,et al. Comparison of polarization properties of human adult microglia and blood‐derived macrophages , 2012, Glia.
[28] D. McTigue,et al. Ferritin Stimulates Oligodendrocyte Genesis in the Adult Spinal Cord and Can Be Transferred from Macrophages to NG2 Cells In Vivo , 2012, The Journal of Neuroscience.
[29] S. David,et al. Iron Efflux from Astrocytes Plays a Role in Remyelination , 2012, The Journal of Neuroscience.
[30] R. Marc Lebel,et al. Quantitative high-field imaging of sub-cortical gray matter in multiple sclerosis , 2012, Multiple sclerosis.
[31] P. Brissot,et al. Non-transferrin bound iron: a key role in iron overload and iron toxicity. , 2012, Biochimica et biophysica acta.
[32] M. Núñez,et al. Iron toxicity in neurodegeneration , 2012, BioMetals.
[33] Robert Zivadinov,et al. Abnormal subcortical deep-gray matter susceptibility-weighted imaging filtered phase measurements in patients with multiple sclerosis A case-control study , 2012, NeuroImage.
[34] Hellmut Merkle,et al. Chronic multiple sclerosis lesions: characterization with high-field-strength MR imaging. , 2012, Radiology.
[35] A. Suttkus,et al. Neuroprotection against iron-induced cell death by perineuronal nets - an in vivo analysis of oxidative stress. , 2012, American journal of neurodegenerative disease.
[36] Hellmut Merkle,et al. Tracking iron in multiple sclerosis: a combined imaging and histopathological study at 7 Tesla. , 2011, Brain : a journal of neurology.
[37] S Ropele,et al. Determinants of brain iron in multiple sclerosis , 2011, Neurology.
[38] C. Vulpe,et al. Iron Efflux from Oligodendrocytes Is Differentially Regulated in Gray and White Matter , 2011, The Journal of Neuroscience.
[39] Massimo Filippi,et al. 7. Mri Assessment of Iron Deposition in Multiple Sclerosis , 2022 .
[40] Phil Lee,et al. Iron deposition is independent of cellular inflammation in a cerebral model of multiple sclerosis , 2011, BMC Neuroscience.
[41] A. Mantovani,et al. Iron trafficking and metabolism in macrophages: contribution to the polarized phenotype. , 2011, Trends in immunology.
[42] Cord Sunderkötter,et al. An unrestrained proinflammatory M1 macrophage population induced by iron impairs wound healing in humans and mice. , 2011, The Journal of clinical investigation.
[43] H. Reichmann,et al. Iron-dependent functions of mitochondria—relation to neurodegeneration , 2011, Journal of Neural Transmission.
[44] P. Apostoli,et al. Polarization dictates iron handling by inflammatory and alternatively activated macrophages , 2010, Haematologica.
[45] G. Shen. Oxidative stress and diabetic cardiovascular disorders: roles of mitochondria and NADPH oxidase. , 2010, Canadian journal of physiology and pharmacology.
[46] J. Pasquini,et al. Oligodendrogenesis: The role of iron , 2010, BioFactors.
[47] L. Vargova,et al. Bral1: Its Role in Diffusion Barrier Formation and Conduction Velocity in the CNS , 2010, The Journal of Neuroscience.
[48] Bejoy Thomas,et al. Principles, techniques, and applications of T2*-based MR imaging and its special applications. , 2009, Radiographics : a review publication of the Radiological Society of North America, Inc.
[49] E. Englander,et al. Elevated metals compromise repair of oxidative DNA damage via the base excision repair pathway: implications of pathologic iron overload in the brain on integrity of neuronal DNA , 2009, Journal of neurochemistry.
[50] D. McTigue,et al. Iron is essential for oligodendrocyte genesis following intraspinal macrophage activation , 2009, Experimental Neurology.
[51] S Ropele,et al. Quantitative assessment of brain iron by R2* relaxometry in patients with clinically isolated syndrome and relapsing–remitting multiple sclerosis , 2009, Multiple sclerosis.
[52] Elizabeth C. Theil,et al. Iron-based redox switches in biology. , 2009, Antioxidants & redox signaling.
[53] B. Todorich,et al. Oligodendrocytes and myelination: The role of iron , 2009, Glia.
[54] Peter K Stys,et al. Virtual hypoxia and chronic necrosis of demyelinated axons in multiple sclerosis , 2009, The Lancet Neurology.
[55] Yansu Guo,et al. Iron is a potential key mediator of glutamate excitotoxicity in spinal cord motor neurons , 2009, Brain Research.
[56] M. Mohsenzadegan,et al. Antioxidant therapy in multiple sclerosis , 2009, Immunopharmacology and immunotoxicology.
[57] C. Guttmann,et al. Deep Gray Matter Involvement on Brain MRI Scans Is Associated with Clinical Progression in Multiple Sclerosis , 2009, Journal of neuroimaging : official journal of the American Society of Neuroimaging.
[58] C. Wiley,et al. Brain Extracellular Matrix in Neurodegeneration , 2008, Brain pathology.
[59] P. Riederer,et al. Iron in neurodegenerative disorders , 2002, Neurotoxicity Research.
[60] S. Nelson,et al. Quantitative in vivo magnetic resonance imaging of multiple sclerosis at 7 Tesla with sensitivity to iron , 2008, Annals of neurology.
[61] D. Kell. Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases , 2008, BMC Medical Genomics.
[62] Hans Lassmann,et al. Mitochondrial defects in acute multiple sclerosis lesions , 2008, Brain : a journal of neurology.
[63] V. Nizet,et al. Role of the hypoxia inducible factors HIF in iron metabolism , 2008, Cell cycle.
[64] V. Nizet,et al. Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs). , 2007, The Journal of clinical investigation.
[65] T. Butz,et al. Intracellular iron concentration of neurons with and without perineuronal nets , 2007 .
[66] D. Rowitch,et al. Insulin‐like growth factor type 1 receptor signaling in the cells of oligodendrocyte lineage is required for normal in vivo oligodendrocyte development and myelination , 2007, Glia.
[67] Xuesheng Zhang,et al. Cellular iron status influences the functional relationship between microglia and oligodendrocytes , 2006, Glia.
[68] T. Rouault,et al. Brain iron metabolism. , 2006, Seminars in pediatric neurology.
[69] T. Rouault. The role of iron regulatory proteins in mammalian iron homeostasis and disease , 2006, Nature chemical biology.
[70] M. Valko,et al. Free radicals, metals and antioxidants in oxidative stress-induced cancer. , 2006, Chemico-biological interactions.
[71] D. Attwell,et al. NMDA receptors are expressed in oligodendrocytes and activated in ischaemia , 2005, Nature.
[72] J. Eaton,et al. Heme, heme oxygenase and ferritin in vascular endothelial cell injury. , 2005, Molecular nutrition & food research.
[73] C. ffrench-Constant,et al. Human diseases reveal novel roles for neural laminins , 2005, Trends in Neurosciences.
[74] L. Fleisher,et al. Iron alters glutamate secretion by regulating cytosolic aconitase activity. , 2005, American journal of physiology. Cell physiology.
[75] Klaus-Armin Nave,et al. High cholesterol level is essential for myelin membrane growth , 2005, Nature Neuroscience.
[76] S. Schwarz,et al. Multiple sclerosis and nutrition , 2005, Multiple sclerosis.
[77] P. Riederer,et al. Perineuronal nets potentially protect against oxidative stress , 2004, Experimental Neurology.
[78] R. Sidman,et al. Integrin-linked kinase is required for laminin-2–induced oligodendrocyte cell spreading and CNS myelination , 2003, The Journal of cell biology.
[79] Z. Cabantchik,et al. Labile plasma iron in iron overload: redox activity and susceptibility to chelation. , 2003, Blood.
[80] J. Connor,et al. Pre- and Postweaning Iron Deficiency Alters Myelination in Sprague-Dawley Rats , 2003, Developmental Neuroscience.
[81] J. Beard,et al. Iron-deficient mice fail to develop autoimmune encephalomyelitis. , 2003, The Journal of nutrition.
[82] J. Eaton,et al. Haem, haem oxygenase and ferritin in vascular endothelial cell injury. , 2003, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
[83] T. Moos. Brain iron homeostasis. , 2002, Danish medical bulletin.
[84] G. Kress,et al. The Relationship between Intracellular Free Iron and Cell Injury in Cultured Neurons, Astrocytes, and Oligodendrocytes , 2002, The Journal of Neuroscience.
[85] T. Taguchi,et al. Histochemical study of perineuronal nets in the retrosplenial cortex of adult rats. , 2002, Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft.
[86] J. Eaton,et al. Molecular bases of cellular iron toxicity. , 2002, Free radical biology & medicine.
[87] R. Sobel,et al. White Matter Extracellular Matrix Chondroitin Sulfate/Dermatan Sulfate Proteoglycans in Multiple Sclerosis , 2001, Journal of neuropathology and experimental neurology.
[88] J. Ting,et al. TNFα promotes proliferation of oligodendrocyte progenitors and remyelination , 2001, Nature Neuroscience.
[89] D. Chaplin,et al. Interleukin-1β Promotes Repair of the CNS , 2001, The Journal of Neuroscience.
[90] D. Morath,et al. Iron modulates the differentiation of a distinct population of glial precursor cells into oligodendrocytes. , 2001, Developmental biology.
[91] W. Willett,et al. Intakes of carotenoids, vitamin C, and vitamin E and MS risk among two large cohorts of women , 2001, Neurology.
[92] F. Torti,et al. Ferritin and the response to oxidative stress. , 2001, Biochemical Journal.
[93] F. Petrat,et al. Subcellular distribution of chelatable iron: a laser scanning microscopic study in isolated hepatocytes and liver endothelial cells. , 2001, The Biochemical journal.
[94] P. Ye,et al. Insulin-Like Growth Factor-1 Inhibits Mature Oligodendrocyte Apoptosis during Primary Demyelination , 2000, The Journal of Neuroscience.
[95] Kristi Kincaid,et al. M-1/M-2 Macrophages and the Th1/Th2 Paradigm1 , 2000, The Journal of Immunology.
[96] S. Lynch,et al. A multiple course trial of desferrioxamine in chronic progressive multiple sclerosis. , 2000, Cellular and molecular biology.
[97] G. Semenza. HIF-1: mediator of physiological and pathophysiological responses to hypoxia. , 2000, Journal of applied physiology.
[98] I. Fridovich. Fundamental Aspects of Reactive Oxygen Species, or What's the Matter with Oxygen? , 1999, Annals of the New York Academy of Sciences.
[99] M. Asanuma,et al. Glial Cells Protect Neurons Against Oxidative Stress via Transcriptional Up‐Regulation of the Glutathione Synthesis , 1999, Journal of neurochemistry.
[100] S. LeVine,et al. Iron deposits in the central nervous system of SJL mice with experimental allergic encephalomyelitis. , 1998, Life sciences.
[101] L. Que,et al. Oxygen activating nonheme iron enzymes. , 1998, Current opinion in chemical biology.
[102] B. Juurlink. Response of Glial Cells to Ischemia: Roles of Reactive Oxygen Species and Glutathione , 1997, Neuroscience & Biobehavioral Reviews.
[103] R. Miledi,et al. Glutamate receptor-mediated toxicity in optic nerve oligodendrocytes. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[104] B. Van Houten,et al. Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[105] S. Lynch,et al. Desferrioxamine in chronic progressive Multiple Sclerosis: a pilot study , 1996, Multiple sclerosis.
[106] B. Juurlink,et al. Low Glutathione and High Iron Govern the Susceptibility of Oligodendroglial Precursors to Oxidative Stress , 1996, Journal of neurochemistry.
[107] J. Connor,et al. Relationship of iron to oligodendrocytes and myelination. , 1996, Glia.
[108] C. Palmer,et al. A histochemical study of iron‐positive cells in the developing rat brain , 1995, The Journal of comparative neurology.
[109] M. Nedergaard,et al. Vitamin E, Ascorbate, Glutathione, Glutathicne Disulfide, and Enzymes of Glutathione Metabolism in Cultures of Chick Astrocytes and Neurons: Evidence that Astrocytes Play an Important Role in Antioxidative Processes in the Brain , 1994, Journal of neurochemistry.
[110] J. Connor,et al. Ferritin, transferrin, and iron in selected regions of the adult and aged rat brain , 1993, The Journal of comparative neurology.
[111] P. Riederer,et al. The possible role of iron in the etiopathology of parkinson's disease , 1993, Movement disorders : official journal of the Movement Disorder Society.
[112] J. Connor,et al. Iron regulation in the brain: Histochemical, biochemical, and molecular considerations , 1992, Annals of neurology.
[113] W. Savino,et al. Influence of iron-deficiency anemia on selected thymus functions in mice: thymulin biological activity, T-cell subsets, and thymocyte proliferation. , 1990, The American journal of clinical nutrition.
[114] C. W. Adams,et al. Perivascular iron deposition and other vascular damage in multiple sclerosis. , 1988, Journal of neurology, neurosurgery, and psychiatry.
[115] J. Brock,et al. Replacement of transferrin in serum-free cultures of mitogen-stimulated mouse lymphocytes by a lipophilic iron chelator. , 1987, Immunology letters.
[116] B. Halliwell,et al. The importance of free radicals and catalytic metal ions in human diseases. , 1985, Molecular aspects of medicine.
[117] W. Cammer. Oligodendrocyte-Associated Enzymes , 1984 .
[118] P. Reichard,et al. Ribonucleotide reductase--a radical enzyme. , 1983, Science.
[119] S. Fahn,et al. Muscle Disorders in Childhood , 1979, Neurology.
[120] D. Pleasure,et al. Enzyme markers for myelination of mouse cerebellum in vivo and in tissue culture , 1976, Brain Research.